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Viruses, Volume 14, Issue 3

March 2022 - 206 articles

Cover Story: Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne nairovirus that causes hemorrhagic fever in humans. The CCHFV nucleoprotein (NP) is the antigen most used for serological screening of CCHFV infection of animals and humans. In this study, we sought to identify epitopes on the NP molecule. We found that the amino acids at positions 161–320 might include dominant epitopes, whereas IgG cross-reactivity to Nairobi sheep disease virus, which is another nairovirus, was limited. Using CCHFV NP-derived synthetic peptides, some potential epitope peptides were also identified. Our results provide useful information to improve NP-based antibody detection assays as well as antigen detection tests relying on anti-NP monoclonal antibodies. View this paper
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Articles (206)

  • Review
  • Open Access
16 Citations
4,440 Views
17 Pages

16 March 2022

HIV-1 viral particle assembly occurs specifically at the plasma membrane and is driven primarily by the viral polyprotein Gag. Selective association of Gag with the plasma membrane is a key step in the viral assembly pathway, which is traditionally a...

  • Article
  • Open Access
9 Citations
3,998 Views
14 Pages

An Improved αvβ6-Receptor-Expressing Suspension Cell Line for Foot-and-Mouth Disease Vaccine Production

  • Yongjie Harvey,
  • Ben Jackson,
  • Brigid Veronica Carr,
  • Kay Childs,
  • Katy Moffat,
  • Graham Freimanis,
  • Chandana Tennakoon,
  • Nicholas Juleff and
  • Julian Seago

16 March 2022

Foot-and-mouth disease (FMD) is endemic in large parts of sub-Saharan Africa, Asia and South America, where outbreaks in cloven-hooved livestock threaten food security and have severe economic impacts. Vaccination in endemic regions remains the most...

  • Article
  • Open Access
29 Citations
5,083 Views
14 Pages

Efficacy Assessment of Phage Therapy in Treating Staphylococcus aureus-Induced Mastitis in Mice

  • Fei Teng,
  • Xiaoyu Xiong,
  • Songsong Zhang,
  • Guiwei Li,
  • Ruichong Wang,
  • Lanlan Zhang,
  • Xiaona Wang,
  • Han Zhou,
  • Jiaxuan Li and
  • Yijing Li
  • + 5 authors

16 March 2022

The primary aim of this study was to evaluate the efficacy of phage against mastitis induced by drug-resistant S. aureus in a mouse model. In this study, five S. aureus phages—4086-1, 4086-2, 4086-3, 4086-4, and 4086-6—were isolated from...

  • Article
  • Open Access
5 Citations
2,941 Views
9 Pages

Lack of Evidence of Chikungunya Virus Infection among Blood Donors during the Chikungunya Outbreak in Lazio Region, Italy, 2017

  • Giulietta Venturi,
  • Massimo Fabiani,
  • Antonello Amendola,
  • Giulia Marsili,
  • Eleonora Benedetti,
  • Cristiano Fiorentini,
  • Claudia Fortuna,
  • Simonetta Pupella,
  • Patrizio Pezzotti and
  • Stefania Vaglio
  • + 4 authors

16 March 2022

Background: The latest European Chikungunya virus (CHIKV) outbreak occurred in Italy in 2017, in the municipalities of Anzio and Rome (Lazio Region), with a secondary outbreak in the Calabrian Region. Most CHIKV infections are symptomatic but about 1...

  • Article
  • Open Access
1 Citations
3,351 Views
16 Pages

16 March 2022

Helicoverpa assulta is a pest that causes severe damage to tobacco, pepper and other cash crops. A local strain of HearNPV-BJ (formerly Helicoverpa assulta nucleopolyhedrovirus (HeasNPV-DJ0031)) was isolated from infected H. assulta larvae in Beijing...

  • Article
  • Open Access
16 Citations
3,710 Views
9 Pages

Avidity of IgG to SARS-CoV-2 RBD as a Prognostic Factor for the Severity of COVID-19 Reinfection

  • Victor Manuylov,
  • Olga Burgasova,
  • Olga Borisova,
  • Svetlana Smetanina,
  • Daria Vasina,
  • Igor Grigoriev,
  • Alexandra Kudryashova,
  • Maria Semashko,
  • Bogdan Cherepovich and
  • Olga Kharchenko
  • + 4 authors

16 March 2022

The avidity index (AI) of IgG to the RBD of SARS-CoV-2 was determined for 71 patients with a mild (outpatient) course of COVID-19, including 39 primarily and 36 secondarily reinfected, and 92 patients with a severe (hospital) course of COVID-19, incl...

  • Article
  • Open Access
10 Citations
4,278 Views
20 Pages

Environmental Effects on Viable Virus Transport and Resuspension in Ventilation Airflow

  • Tatiana A. Baig,
  • Meiyi Zhang,
  • Brooke L. Smith and
  • Maria D. King

16 March 2022

To understand how SARS-CoV-2 spreads indoors, in this study bovine coronavirus was aerosolized as simulant into a plexiglass chamber with coupons of metal, wood and plastic surfaces. After aerosolization, chamber and coupon surfaces were swiped to qu...

  • Article
  • Open Access
8 Citations
3,716 Views
13 Pages

Four Weeks Treatment with Glecaprevir/Pibrentasvir + Ribavirin—A Randomized Controlled Clinical Trial

  • Lone W. Madsen,
  • Peer B. Christensen,
  • Janne F. Hansen,
  • Birgit T. Røge,
  • Dorte K. Holm,
  • Sandra Dröse and
  • Anne Øvrehus

16 March 2022

Enhancing treatment uptake for hepatitis C to achieve the elimination goals set by the World Health Organization could be achieved by reducing the treatment duration. The aim of this study was to compare the sustained virological response at week 12...

  • Review
  • Open Access
6 Citations
4,186 Views
14 Pages

15 March 2022

Infectious diseases such as the ongoing coronavirus disease 2019 (COVID-19) continue to have a huge impact on global health, and the host-virus interaction remains incompletely understood. To address the global threat, in-depth investigations in path...

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Viruses - ISSN 1999-4915