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Viruses, Volume 14, Issue 3

March 2022 - 206 articles

Cover Story: Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne nairovirus that causes hemorrhagic fever in humans. The CCHFV nucleoprotein (NP) is the antigen most used for serological screening of CCHFV infection of animals and humans. In this study, we sought to identify epitopes on the NP molecule. We found that the amino acids at positions 161–320 might include dominant epitopes, whereas IgG cross-reactivity to Nairobi sheep disease virus, which is another nairovirus, was limited. Using CCHFV NP-derived synthetic peptides, some potential epitope peptides were also identified. Our results provide useful information to improve NP-based antibody detection assays as well as antigen detection tests relying on anti-NP monoclonal antibodies. View this paper
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Articles (206)

  • Article
  • Open Access
6 Citations
3,369 Views
20 Pages

Infection of Human Endothelial Cells with Lassa Virus Induces Early but Transient Activation and Low Type I IFN Response Compared to the Closely-Related Nonpathogenic Mopeia Virus

  • Othmann Merabet,
  • Natalia Pietrosemoli,
  • Emeline Perthame,
  • Jean Armengaud,
  • Jean-Charles Gaillard,
  • Virginie Borges-Cardoso,
  • Maïlys Daniau,
  • Catherine Legras-Lachuer,
  • Xavier Carnec and
  • Sylvain Baize

21 March 2022

Lassa virus (LASV), an Old World arenavirus, is responsible for hemorrhagic fevers in western Africa. The privileged tropism of LASV for endothelial cells combined with a dysregulated inflammatory response are the main cause of the increase in vascul...

  • Article
  • Open Access
20 Citations
4,597 Views
18 Pages

Characterization of Serum and Mucosal SARS-CoV-2-Antibodies in HIV-1-Infected Subjects after BNT162b2 mRNA Vaccination or SARS-CoV-2 Infection

  • Katja G. Schmidt,
  • Ellen G. Harrer,
  • Koray Tascilar,
  • Sabrina Kübel,
  • Boutaina El Kenz,
  • Fabian Hartmann,
  • David Simon,
  • Georg Schett,
  • Krystelle Nganou-Makamdop and
  • Thomas Harrer

21 March 2022

Only limited data are available regarding the immunogenicity of the BNT162b2 mRNA vaccine in HIV-1+ patients. Therefore, we investigated the humoral immune response after BNT162b2-mRNA vaccination or SARS-CoV-2 infection in HIV-1+ patients on antiret...

  • Brief Report
  • Open Access
15 Citations
3,077 Views
9 Pages

Effects of Casirivimab/Imdevimab Monoclonal Antibody Treatment among Vaccinated Patients Infected by SARS-CoV-2 Delta Variant

  • Gaetano Cicchitto,
  • Lorena Cardillo,
  • Claudio de Martinis,
  • Paola Sabatini,
  • Rosita Marchitiello,
  • Giovanna Abate,
  • Adele Rovetti,
  • Antonietta Cavallera,
  • Camillo Apuzzo and
  • Francesco Ferrigno
  • + 1 author

21 March 2022

There is a growing interest in using monoclonal antibodies (mAbs) in the early stages of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection to prevent disease progression. Little is known about the efficacy of mAbs against the del...

  • Article
  • Open Access
11 Citations
3,478 Views
17 Pages

21 March 2022

Canegrubs (Coleoptera: Scarabaeidae) are major pests of sugarcane crops in Australia, but despite long-term and intensive research, no commercially viable biological control agents have been identified. We used the RNA-Seq approach to explore the vir...

  • Review
  • Open Access
8 Citations
7,601 Views
14 Pages

21 March 2022

Obtaining an understanding of the mechanism underlying the interrelations between the structure and function of HIV-1 is of pivotal importance. In previous decades, this mechanism was addressed extensively in a variety of studies using conventional a...

  • Article
  • Open Access
10 Citations
3,743 Views
15 Pages

Risk Factors for Norovirus Infections and Their Association with Childhood Growth: Findings from a Multi-Country Birth Cohort Study

  • Parag Palit,
  • Rina Das,
  • Md. Ahshanul Haque,
  • Md. Mehedi Hasan,
  • Zannatun Noor,
  • Mustafa Mahfuz,
  • Abu Syed Golam Faruque and
  • Tahmeed Ahmed

21 March 2022

The prevalence of norovirus infections in different geographical locations and their attribution to childhood diarrhea is well established. However, there are no reports showing possible relationships of different norovirus genogroups with subsequent...

  • Article
  • Open Access
37 Citations
4,509 Views
17 Pages

TREC/KREC Levels and T and B Lymphocyte Subpopulations in COVID-19 Patients at Different Stages of the Disease

  • Andrei A. Savchenko,
  • Elena Tikhonova,
  • Igor Kudryavtsev,
  • Dmitry Kudlay,
  • Ilya Korsunsky,
  • Vasily Beleniuk and
  • Alexandr Borisov

21 March 2022

Background: T and B cell-mediated immunity can be assessed using T cell receptor excision circle (TREC) and Kappa-deleting recombination excision circle (KREC) analysis, respectively, and successful implementation of this method requires evaluation o...

  • Conference Report
  • Open Access
1 Citations
3,010 Views
14 Pages

The 32nd Brazilian Society of Virology (SBV) 2021 Annual Meeting

  • Maite Freitas Silva Vaslin,
  • Alessandra Alevato Leal,
  • Larissa Mayumi Bueno,
  • Cíntia Bittar,
  • Gabriela Fabiano de Souza,
  • Karine Lourenço,
  • Gustavo Peixoto Duarte da Silva,
  • Maria Isabel Maldonado Coelho Guedes,
  • José Luiz Proença-Módena and
  • João Pessoa Araújo Junior
  • + 2 authors

20 March 2022

The Brazilian Society of Virology has been organizing annual meetings for 32 years now. The 32nd annual meeting, which occurred in 2021, was once again an online meeting in consequence of the issues imposed by COVID-19, even with the vaccination adva...

  • Article
  • Open Access
9 Citations
3,778 Views
12 Pages

Prevalence, Genetics and Evolutionary Properties of Eurasian Avian-like H1N1 Swine Influenza Viruses in Liaoning

  • Hailing Li,
  • Haoyu Leng,
  • Siqi Tang,
  • Chaofan Su,
  • Yina Xu,
  • Yongtao Wang,
  • Jiaming Lv,
  • Shiwei Zhang,
  • Yali Feng and
  • Shaokang Song
  • + 1 author

20 March 2022

Swine influenza virus (SIV) is an important zoonosis pathogen. The 2009 pandemic of H1N1 influenza A virus (2009/H1N1) highlighted the importance of the role of pigs as intermediate hosts. Liaoning province, located in northeastern China, has become...

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Viruses - ISSN 1999-4915