Special Issue "Respiratory Viral Coinfection"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 25 December 2021.

Special Issue Editor

Dr. Kelvin Kai-Wang To
E-Mail Website
Guest Editor
Department of Microbiology, The University of Hong Kong, Hong Kong, China
Interests: respiratory tract infection; respiratory pathogens; vaccines; diagnostic; disease surveillance; disease dynamics indagation; population surveillance

Special Issue Information

Dear Colleagues,

Respiratory virus infection is an important cause of morbidity and mortality in humans. With the advance in molecular diagnostic assays, multiple respiratory viruses are often detected in clinical specimens from patients with respiratory tract infection. The contribution of respiratory virus co-infection to the pathogenesis and clinical outcome of respiratory tract infection remains unclear for many viruses, especially for the SARS-CoV-2 that causes the COVID-19 pandemic. In this Special Issue, we welcome studies which addresses respiratory viral co-infection. The scope will include epidemiological, clinical, immunological, virological and diagnostic studies on respiratory virus co-infection.

Dr. Kelvin Kai-Wang To
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Article
Lower Respiratory Tract Infection and Genus Enterovirus in Children Requiring Intensive Care: Clinical Manifestations and Impact of Viral Co-Infections
Viruses 2021, 13(10), 2059; https://doi.org/10.3390/v13102059 - 14 Oct 2021
Viewed by 367
Abstract
Infection by rhinovirus (RV) and enterovirus (EV) in children ranges from asymptomatic infection to severe lower respiratory tract infection (LRTI). This cohort study evaluates the clinical impact of RV/EV species, alone or in codetection with other viruses, in young children with severe LRTI. [...] Read more.
Infection by rhinovirus (RV) and enterovirus (EV) in children ranges from asymptomatic infection to severe lower respiratory tract infection (LRTI). This cohort study evaluates the clinical impact of RV/EV species, alone or in codetection with other viruses, in young children with severe LRTI. Seventy-one patients aged less than 5 years and admitted to the Paediatric Intensive Care Unit (PICU) of a reference children’s hospital with RV or EV (RV/EV) LRTI were prospectively included from 1/2018 to 3/2020. A commercial PCR assay for multiple respiratory pathogens was performed in respiratory specimens. In 22/71, RV/EV + respiratory syncytial virus (RSV) was found, and 18/71 had RV/EV + multiple viral detections. Patients with single RV/EV detection required invasive mechanical ventilation (IMV) as frequently as those with RSV codetection, whereas none of those with multiple viral codetections required IMV. Species were determined in 60 samples, 58 being RV. No EV-A, EV-C, or EV-D68 were detected. RV-B and EV-B were only found in patients with other respiratory virus codetections. There were not any associations between RV/EV species and severity outcomes. To conclude, RV/EV detection alone was observed in young children with severe disease, while multiple viral codetections may result in reduced clinical severity. Differences in pathogenicity between RV and EV species could not be drawn. Full article
(This article belongs to the Special Issue Respiratory Viral Coinfection)
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