Table of Contents
Viruses, Volume 11, Issue 9 (September 2019) – 113 articles
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Cover Story (view full-size image) APOBEC3 (A3) proteins are key components of innate cellular defense against lentiviruses. In cats, [...] Read more. APOBEC3 (A3) proteins are key components of innate cellular defense against lentiviruses. In cats, the A3Z3 and A3Z2-Z3 proteins mediate restriction of feline immunodeficiency virus (FIV) infection. We quantified cat A3 mRNA expression in response to cytokines and FIV infection in vitro and in vivo. We found that cytokines upregulate A3 expression, but by and large, FIV infection did not appear to alter expression. A3Z3 mRNA abundance exceeded that of A3Z2-Z3 by 300-fold or more in all cells and tissues, suggesting that A3Z3 may be the primary anti-lentiviral A3 gene product in cats. View this paper.