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Viruses, Volume 11, Issue 9

September 2019 - 113 articles

Cover Story: APOBEC3 (A3) proteins are key components of innate cellular defense against lentiviruses. In cats, the A3Z3 and A3Z2-Z3 proteins mediate restriction of feline immunodeficiency virus (FIV) infection. We quantified cat A3 mRNA expression in response to cytokines and FIV infection in vitro and in vivo. We found that cytokines upregulate A3 expression, but by and large, FIV infection did not appear to alter expression. A3Z3 mRNA abundance exceeded that of A3Z2-Z3 by 300-fold or more in all cells and tissues, suggesting that A3Z3 may be the primary anti-lentiviral A3 gene product in cats. View this paper.
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Articles (113)

  • Article
  • Open Access
11 Citations
5,557 Views
15 Pages

19 September 2019

Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating infectious diseases in pigs worldwide. The causative agent is the PRRS virus (PRRSV). In this study, we explored polyethylenimine (PEI), a cationic polym...

  • Article
  • Open Access
13 Citations
4,764 Views
12 Pages

Prevalence and Correlates of Pre-Treatment HIV Drug Resistance among HIV-Infected Children in Ethiopia

  • Birkneh Tilahun Tadesse,
  • Olivia Tsai,
  • Adugna Chala,
  • Tolossa Eticha Chaka,
  • Temesgen Eromo,
  • Hope R. Lapointe,
  • Bemuluyigza Baraki,
  • Aniqa Shahid,
  • Sintayehu Tadesse and
  • Eyasu Makonnen
  • + 3 authors

19 September 2019

Pediatric human immunodeficiency virus (HIV) care in resource-limited settings remains a major challenge to achieving global HIV treatment and virologic suppression targets, in part because the administration of combination antiretroviral therapies (...

  • Review
  • Open Access
21 Citations
8,363 Views
17 Pages

Chasing Intracellular Zika Virus Using Proteomics

  • Pietro Scaturro,
  • Anna Lena Kastner and
  • Andreas Pichlmair

19 September 2019

Flaviviruses are the most medically relevant group of arboviruses causing a wide range of diseases in humans and are associated with high mortality and morbidity, as such posing a major health concern. Viruses belonging to this family can be endemic...

  • Article
  • Open Access
9 Citations
4,759 Views
14 Pages

19 September 2019

In soybean cultivar L29, the Rsv3 gene is responsible for extreme resistance (ER) against the soybean mosaic virus avirulent strain G5H, but is ineffective against the virulent strain G7H. Part of this ER is attributed to the rapid increase in abscis...

  • Article
  • Open Access
11 Citations
5,273 Views
19 Pages

A Novel CXCR4 Targeting Protein SDF-1/54 as an HIV-1 Entry Inhibitor

  • Suiyi Tan,
  • Wenjuan Li,
  • Zhaofeng Li,
  • Yujing Li,
  • Jiangyan Luo,
  • Liangzhentian Yu,
  • Jie Yang,
  • Mengjie Qiu,
  • Hongyan Cheng and
  • Wei Xu
  • + 4 authors

18 September 2019

CXC chemokine receptor 4 (CXCR4) is a co-receptor for HIV-1 entry into target cells. Its natural ligand, the chemokine SDF-1, inhibits viral entry mediated by this receptor. However, the broad expression pattern of CXCR4 and its critical roles in var...

  • Article
  • Open Access
32 Citations
5,299 Views
15 Pages

Identification of Two Porcine Reproductive and Respiratory Syndrome Virus Variants Sharing High Genomic Homology but with Distinct Virulence

  • Nanhua Chen,
  • Mengxue Ye,
  • Yucheng Huang,
  • Shuai Li,
  • Yanzhao Xiao,
  • Xinshuai Li,
  • Shubin Li,
  • Xiangdong Li,
  • Xiuling Yu and
  • Kegong Tian
  • + 1 author

18 September 2019

Porcine reproductive and respiratory syndrome virus (PRRSV) causes huge economic loss to the global swine industry. Even though several control strategies have been applied, PRRS is still not effectively controlled due to the continuous emergence of...

  • Review
  • Open Access
132 Citations
12,820 Views
14 Pages

An Update on African Swine Fever Virology

  • Axel Karger,
  • Daniel Pérez-Núñez,
  • Jesús Urquiza,
  • Patricia Hinojar,
  • Covadonga Alonso,
  • Ferdinando B. Freitas,
  • Yolanda Revilla,
  • Marie-Frédérique Le Potier and
  • Maria Montoya

17 September 2019

Animal diseases constitute a continuing threat to animal health, food safety, national economy, and the environment. Among those, African swine fever (ASF) is one of the most devastating viruses affecting pigs and wild suids due to the lack of vaccin...

  • Article
  • Open Access
17 Citations
15,644 Views
16 Pages

Metaviromics Reveals Unknown Viral Diversity in the Biting Midge Culicoides impunctatus

  • Sejal Modha,
  • Joseph Hughes,
  • Giovanni Bianco,
  • Heather M. Ferguson,
  • Barbara Helm,
  • Lily Tong,
  • Gavin S. Wilkie,
  • Alain Kohl and
  • Esther Schnettler

17 September 2019

Biting midges (Culicoides species) are vectors of arboviruses and were responsible for the emergence and spread of Schmallenberg virus (SBV) in Europe in 2011 and are likely to be involved in the emergence of other arboviruses in Europe. Improved sur...

  • Review
  • Open Access
77 Citations
10,099 Views
16 Pages

African Swine Fever: Fast and Furious or Slow and Steady?

  • Katja Schulz,
  • Franz Josef Conraths,
  • Sandra Blome,
  • Christoph Staubach and
  • Carola Sauter-Louis

17 September 2019

Since the introduction of African swine fever (ASF) into Georgia in 2007, the disease has been spreading in an unprecedented way. Many countries that are still free from the disease fear the emergence of ASF in their territory either in domestic pigs...

  • Review
  • Open Access
49 Citations
11,121 Views
24 Pages

Vector Competence: What Has Zika Virus Taught Us?

  • Sasha R. Azar and
  • Scott C. Weaver

17 September 2019

The unprecedented outbreak of Zika virus (ZIKV) infection in the Americas from 2015 to 2017 prompted the publication of a large body of vector competence data in a relatively short period of time. Although differences in vector competence as a result...

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Viruses - ISSN 1999-4915