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Current Oncology, Volume 32, Issue 2

February 2025 - 63 articles

Cover Story: The peritoneum is the second most common site of metastasis in patients with pancreatic ductal adenocarcinoma (PDAC), accounting for significant morbidity and driving mortality. Intraperitoneal therapeutics are a promising option for treating peritoneal metastasis (PM). Better penetration of tumor tissue can be achieved with less systemic toxicity compared with intravenous chemotherapy. Locoregional control may benefit a subset of patients with limited PM who are otherwise not considered for curative treatment. We describe the current state of management of PM from PDAC and review the available data exploring peritoneal-directed therapy, including cytoreductive surgery (CRS), normothermic intraperitoneal chemotherapy (NIPEC), heated intraperitoneal chemotherapy (HIPEC), and pressurized intraperitoneal aerosolized chemotherapy (PIPAC). View this paper
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Articles (63)

  • Article
  • Open Access
1 Citations
3,022 Views
12 Pages

Outcomes of Allogeneic Stem Cell Transplant in Patients with Relapsed/Refractory Hodgkin Lymphoma

  • Shiliang Ge,
  • Kylie Lepic,
  • Ravi Bhindi,
  • Tobias Berg,
  • Dina Khalaf,
  • Brian Leber,
  • Michael Radford,
  • Irwin Walker,
  • Gwynivere Davies and
  • Alejandro Garcia-Horton

18 February 2025

Background: The aim of this study was to evaluate real-world clinical outcomes and transplant-related complications of allogeneic stem cell transplantation (alloSCT) for Hodgkin lymphoma (HL). Methods: This was a single-centre, retrospective analysis...

  • Article
  • Open Access
1,451 Views
14 Pages

18 February 2025

Background: Colorectal cancer liver metastasis (CRLM) is a significant contributor to cancer-related illness and death. Neoadjuvant chemotherapy (NAC) is an essential treatment approach; however, optimal patient selection remains a challenge. This st...

  • Article
  • Open Access
2,258 Views
18 Pages

MRI in Oral Tongue Squamous Cell Carcinoma: A Radiomic Approach in the Local Recurrence Evaluation

  • Antonello Vidiri,
  • Vincenzo Dolcetti,
  • Francesco Mazzola,
  • Sonia Lucchese,
  • Francesca Laganaro,
  • Francesca Piludu,
  • Raul Pellini,
  • Renato Covello and
  • Simona Marzi

18 February 2025

(1) Background: Oral tongue squamous cell carcinoma (OTSCC) is a prevalent malignancy with high loco-regional recurrence. Advanced imaging biomarkers are critical for stratifying patients at a high risk of recurrence. This study aimed to develop MRI-...

  • Case Report
  • Open Access
2,189 Views
15 Pages

18 February 2025

Background: Metastatic castration-resistant prostate cancer (mCRPC) remains challenging due to progression despite androgen deprivation therapy (ADT). Current treatments, including androgen receptor-targeted agents, chemotherapy, bone-targeted agents...

  • Article
  • Open Access
1,315 Views
13 Pages

TM7SF2 as a Potential Biomarker in Colorectal Cancer: Implications for Metastasis

  • Inpyo Hong,
  • Sooyoun Kim,
  • Minho Lee,
  • Seoin Han,
  • Hak Chun Kim,
  • Chong Woo Chu,
  • Seong Geun Kim,
  • Min Kyung Kim,
  • Chang Jin Kim and
  • Dong Hyun Kang
  • + 5 authors

17 February 2025

Colorectal cancer (CRC) is a commonly fatal cancer and ranks as the fourth most prevalent in men and third in women worldwide. While early-stage survival rates are high, they significantly decrease with recurrence and metastasis. Thus, the early dete...

  • Review
  • Open Access
4 Citations
1,972 Views
12 Pages

Endoscopic Ultrasound-Guided Locoregional Treatments for Pancreatic Neuroendocrine Neoplasms

  • Graziella Masciangelo,
  • Davide Campana,
  • Claudio Ricci,
  • Elisa Andrini,
  • Emilija Rakichevikj,
  • Pietro Fusaroli and
  • Andrea Lisotti

16 February 2025

Pancreatic neuroendocrine neoplasms (pNENs) represent approximately 2% of all solid pancreatic tumors. The incidence of pNENs has been increasing in the last decade. The clinical manifestations of pNENs range from hormone secretion syndromes in funct...

  • Systematic Review
  • Open Access
5 Citations
4,385 Views
20 Pages

16 February 2025

Objective: To compare the efficacy and safety of immunotherapy combined with chemotherapy as the first-line treatment for advanced gastric cancer. Data Sources: Phase III randomised controlled trials were searched from PubMed, Embase, Web of Science,...

  • Article
  • Open Access
1,595 Views
19 Pages

“I Got My Trophy”: The Story of Implementing a Neuro-Oncology Exercise Program from the Patient and Caregiver Lens—A Qualitative Study

  • Julia T. Daun,
  • Mannat Bansal,
  • Randall L. Iversen,
  • Meghan H. McDonough,
  • Gloria Roldan Urgoiti,
  • Tana Dhruva,
  • Emma McLaughlin,
  • Lauren C. Capozzi,
  • Jacob C. Easaw and
  • Margaret L. McNeely
  • + 2 authors

16 February 2025

The purpose of this study was to gather patient and caregiver perspectives of adult neuro-oncology patients participating in a 12-week exercise program (i.e., the Alberta Cancer Exercise-Neuro-Oncology; ACE-Neuro study). Patients and their caregivers...

  • Review
  • Open Access
3 Citations
3,812 Views
13 Pages

Perioperative Chemo-Immunotherapy in Non-Oncogene-Addicted Resectable Non-Small Cell Lung Cancer (NSCLC): Italian Expert Panel Meeting

  • Filippo de Marinis,
  • Andrea Ardizzoni,
  • Ilaria Attili,
  • Laura Bonanno,
  • Emilio Bria,
  • Diego Luigi Cortinovis,
  • Stefano Margaritora,
  • Francesca Mazzoni,
  • Edoardo Mercadante and
  • Alessandro Morabito
  • + 7 authors

14 February 2025

Background: Immunotherapy (IO)-based strategies have been demonstrated to significantly prolong survival in the perioperative setting of non-oncogene-addicted non-small cell lung cancer (NSCLC). The adoption of such strategies in clinical practice de...

  • Review
  • Open Access
4 Citations
2,508 Views
15 Pages

Multimodal Prehabilitation for Gynecologic Cancer Surgery

  • Jeongyun Kim,
  • Chae Hyeong Lee and
  • Ga Won Yim

14 February 2025

Surgical treatment is commonly employed to treat patients with gynecologic cancer, although surgery itself may function as a stressor, reducing the patients’ functional capacity and recovery. Prehabilitation programs attempt to improve patients...

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Curr. Oncol. - ISSN 1718-7729