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Marine Drugs, Volume 16, Issue 10

October 2018 - 55 articles

Cover Story: Considering the dramatic increment of multidrug-resistant microbial strains and the urgent need to combat relevant pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa, we previously focused on antimicrobial peptides (AMPs) from Echinoderms as Paracentrin 1(SP1), a peptide fragment of a sea urchin thymosin and in this study we obtained by recombination a SP1 derivative 22 amino acids longer called RP1.
The RP1, was considerably more active than SP1 against the planktonic and biofilm growth forms of S. aureus ATCC 25923 and P. aeruginosa ATCC 15442. The results with molecular dynamics (MD) simulations obtained point out that RP1 shows a remarkable preference for bacterial membranes, in agreement with the antibacterial activity in vitro. Our results lay the foundation for the development of novel AMPs using RP1 scaffold as a potential and effective template. View this paper.
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Articles (55)

  • Review
  • Open Access
70 Citations
7,377 Views
21 Pages

Bioaccessibility of Marine Carotenoids

  • Isabel Viera,
  • Antonio Pérez-Gálvez and
  • María Roca

22 October 2018

The benefit of carotenoids to human health is undeniable and consequently, their use for this purpose is growing rapidly. Additionally, the nutraceutical properties of carotenoids have attracted attention of the food industry, especially in a new mar...

  • Article
  • Open Access
9 Citations
4,282 Views
18 Pages

A High-Content Screening Assay for the Discovery of Novel Proteasome Inhibitors from Formosan Soft Corals

  • Xue-Hua Ling,
  • Shang-Kwei Wang,
  • Yun-Hsuan Huang,
  • Min-Jay Huang and
  • Chang-Yih Duh

21 October 2018

The ubiquitin-proteasome system (UPS) is a major proteolytic pathway that safeguards protein homeostasis. The main 26S proteasome consists of a 20S catalytic core proteasome and a 19S substrate recognition proteasome. UPS dysfunction underlies many i...

  • Article
  • Open Access
30 Citations
7,517 Views
10 Pages

21 October 2018

Jellyfish is a compartment in the marine food web that often achieves high increases of biomass and that it is starting to be explored for several human potential uses. In this paper, a recently rediscovered large jellyfish, Rhizostoma luteum, is stu...

  • Article
  • Open Access
17 Citations
4,956 Views
12 Pages

20 October 2018

Metabolomics has become an important tool in the search for bioactive compounds from natural sources, with the recent inclusion of marine organisms. Of the several steps performed in metabolomics studies, the extraction process is a crucial step&mdas...

  • Article
  • Open Access
61 Citations
5,385 Views
19 Pages

20 October 2018

In this report, acid-soluble collagen (ASC-MC) and pepsin-soluble collagen (PSC-MC) were extracted from the scales of miiuy croaker (Miichthys miiuy) with yields of 0.64 ± 0.07% and 3.87 ± 0.15% of dry weight basis, respectively. ASC-MC...

  • Article
  • Open Access
52 Citations
8,881 Views
14 Pages

Fucoidan Inhibits Radiation-Induced Pneumonitis and Lung Fibrosis by Reducing Inflammatory Cytokine Expression in Lung Tissues

  • Hsin-Hsien Yu,
  • Edward Chengchuan KO,
  • Chia-Lun Chang,
  • Kevin Sheng-Po Yuan,
  • Alexander T. H. Wu,
  • Yan-Shen Shan and
  • Szu-Yuan Wu

19 October 2018

Purpose: Radiotherapy is a crucial treatment approach for many types of cancer. Radiation pneumonitis (RP) is one of the major complications in chest irradiation. Fucoidan is a sulfated polysaccharide found mainly in various species of brown seaweed....

  • Article
  • Open Access
22 Citations
6,086 Views
12 Pages

1H NMR Spectroscopy and MVA to Evaluate the Effects of Caulerpin-Based Diet on Diplodus sargus Lipid Profiles

  • Laura Del Coco,
  • Serena Felline,
  • Chiara Roberta Girelli,
  • Federica Angilè,
  • Laura Magliozzi,
  • Frederico Almada,
  • Biagio D’Aniello,
  • Ernesto Mollo,
  • Antonio Terlizzi and
  • Francesco P. Fanizzi

18 October 2018

The biological invasion of the green algae Caulerpa cylindracea represents a serious scientific and public issue in the Mediterranean Sea, essentially due to strong modifications both to habitat structure and native benthic communities. Although alte...

  • Article
  • Open Access
9 Citations
4,216 Views
13 Pages

Characterization of MK8(H2) from Rhodococcus sp. B7740 and Its Potential Antiglycation Capacity Measurements

  • Yashu Chen,
  • Qin Mu,
  • Kai Hu,
  • Mo Chen,
  • Jifang Yang,
  • Jigang Chen,
  • Bijun Xie and
  • Zhida Sun

18 October 2018

Menaquinone (MK) has an important role in human metabolism as an essential vitamin (VK2), which is mainly produced through the fermentation of microorganisms. MK8(H2) was identified to be the main menaquinone from Rhodococcus sp. B7740, a bacterium i...

  • Article
  • Open Access
56 Citations
5,773 Views
12 Pages

Structure and Anti-Inflammatory Activity of a New Unusual Fucosylated Chondroitin Sulfate from Cucumaria djakonovi

  • Nadezhda E. Ustyuzhanina,
  • Maria I. Bilan,
  • Elena G. Panina,
  • Nadezhda P. Sanamyan,
  • Andrey S. Dmitrenok,
  • Eugenia A. Tsvetkova,
  • Natalia A. Ushakova,
  • Alexander S. Shashkov,
  • Nikolay E. Nifantiev and
  • Anatolii I. Usov

17 October 2018

Fucosylated chondroitin sulfate CD was isolated from the sea cucumber Cucumaria djakonovi collected from the Avachinsky Gulf of the eastern coast of Kamchatka. Structural characterization of CD was performed using a series of non-destructive NMR spec...

  • Article
  • Open Access
31 Citations
5,472 Views
32 Pages

16 October 2018

Alzheimer’s disease (AD) is becoming one of the most disturbing health and socioeconomic problems nowadays, as it is a neurodegenerative pathology with no treatment, which is expected to grow further due to population ageing. Actual treatments...

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Mar. Drugs - ISSN 1660-3397