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Mar. Drugs 2018, 16(10), 390; https://doi.org/10.3390/md16100390

1H NMR Spectroscopy and MVA to Evaluate the Effects of Caulerpin-Based Diet on Diplodus sargus Lipid Profiles

1
Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali (Di.S.Te.B.A.), Università del Salento, 73100 Lecce, Italy
2
Consorzio Interuniversitario per le Scienze del Mare (CoNISMa), 00196 Roma, Italy
3
Dipartimento di Biologia, Università degli Studi di Napoli “Federico II”, 80126 Napoli, Italy
4
MARE—Marine and Environmental Sciences Centre, ISPA—Instituto Universitário, 1140-041 Lisbon, Portugal
5
Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli, Italy
6
Dipartimento di Scienze della Vita, Università degli studi di Trieste, 34127 Trieste, Italy
7
Department of Biology and Evolution of Marine Organisms, Stazione Zoologica A. Dohrn, 80121 Napoli, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 1 October 2018 / Revised: 13 October 2018 / Accepted: 16 October 2018 / Published: 18 October 2018
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Abstract

The biological invasion of the green algae Caulerpa cylindracea represents a serious scientific and public issue in the Mediterranean Sea, essentially due to strong modifications both to habitat structure and native benthic communities. Although alterations in health status and changes in flesh quality of some marine species (dietary exposed to C. cylindracea) have been observed, no studies on cause-effect relationships have been carried out. Here, for the first time, through a controlled feeding experiment followed by 1H NMR Spectroscopy and multivariate analysis (PCA, OPLS-DA), we showed that caulerpin taken with diet is directly responsible of changes observed in metabolic profile of fish flesh, including alteration of lipid metabolism, in particular with a reduction of ω3 PUFA content. The potential of caulerpin to directly modulate lipid metabolism opens up new questions about causal mechanism triggered by algal metabolite also in view of a possible exploitation in the nutraceutical/medical field. View Full-Text
Keywords: biological invasion; Caulerpa cylindracea; secondary metabolites; Diplodus sargus; metabolomics; NMR spectroscopy biological invasion; Caulerpa cylindracea; secondary metabolites; Diplodus sargus; metabolomics; NMR spectroscopy
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Del Coco, L.; Felline, S.; Girelli, C.R.; Angilè, F.; Magliozzi, L.; Almada, F.; D’Aniello, B.; Mollo, E.; Terlizzi, A.; Fanizzi, F.P. 1H NMR Spectroscopy and MVA to Evaluate the Effects of Caulerpin-Based Diet on Diplodus sargus Lipid Profiles. Mar. Drugs 2018, 16, 390.

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