Table of Contents
Pharmaceuticals, Volume 12, Issue 2 (June 2019)
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Cover Story (view full-size image) HIV-1 inhibition by the long-acting antiviral 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA). The [...] Read more. HIV-1 inhibition by the long-acting antiviral 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA). The active site of HIV-1 reverse transcriptase (RT) (thumb (green), palm (red), and fingers (blue) subdomain) bound to template (cyan) annealed to EFdA-terminated primer (yellow). The monophosphate form of EFdA (colored atoms: carbons in gray, oxygens in red, nitrogen in blue, fluorine in green, phosphorus in orange) is shown incorporated at the 3'-end of the primer, with the 4'-ethynyl group of EFdA strongly bound at a conserved hydrophobic pocket (in cyan), thus blocking RT translocation and further DNA synthesis. View this paper.