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Ironing out Macrophage Immunometabolism

Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy
Author to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(2), 94;
Received: 31 May 2019 / Revised: 14 June 2019 / Accepted: 17 June 2019 / Published: 19 June 2019
(This article belongs to the Special Issue Iron as Therapeutic Targets in Human Diseases)
PDF [655 KB, uploaded 19 June 2019]


Over the last decade, increasing evidence has reinforced the key role of metabolic reprogramming in macrophage activation. In addition to supporting the specific immune response of different subsets of macrophages, intracellular metabolic pathways also directly control the specialized effector functions of immune cells. In this context, iron metabolism has been recognized as an important component of macrophage plasticity. Since macrophages control the availability of this essential metal, changes in the expression of genes coding for the major proteins of iron metabolism may result in different iron availability for the macrophage itself and for other cells in the microenvironment. In this review, we discuss how macrophage iron can also play a role in immunometabolism. View Full-Text
Keywords: macrophages; iron; metabolism; inflammation macrophages; iron; metabolism; inflammation

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Recalcati, S.; Gammella, E.; Cairo, G. Ironing out Macrophage Immunometabolism. Pharmaceuticals 2019, 12, 94.

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