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Psychotropic Drugs for the Management of Chronic Pain and Itch

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Torez 44, St. Petersburg 194223, Russia
International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin 9, Ireland
Department of Pedagogy and Psychology, Faculty of Postgraduate Education, First Pavlov State Medical University, L’va Tolstogo str. 6-8, St. Petersburg 197022, Russia
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceuticals 2019, 12(2), 99;
Received: 26 May 2019 / Revised: 19 June 2019 / Accepted: 21 June 2019 / Published: 24 June 2019
(This article belongs to the Special Issue The Story of Successful Drugs and Recent FDA-Approved Molecules)
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Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvulsants. It is known that some psychotropic drugs are also effective for the treatment of neuropathic pain and pruritus syndromes due to interaction with the secondary molecular targets. Our own clinical studies have identified antipruritic and/or analgesic efficacy of the following compounds: tianeptine (atypical tricyclic antidepressant), citalopram (selective serotonin reuptake inhibitor), mianserin (tetracyclic antidepressant), carbamazepine (anticonvulsant), trazodone (serotonin antagonist and reuptake inhibitor), and chlorprothixene (antipsychotic). Venlafaxine (serotonin-norepinephrine reuptake inhibitor) is known to have an analgesic effect too. The mechanism of such effect of these drugs is not fully understood. Herein we review and correlate the literature data on analgesic/antipruritic activity with pharmacological profile of these compounds. View Full-Text
Keywords: chronic pain; psychotropic drugs; pharmacological profile; animal model; clinical trial chronic pain; psychotropic drugs; pharmacological profile; animal model; clinical trial

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Belinskaia, D.A.; Belinskaia, M.A.; Barygin, O.I.; Vanchakova, N.P.; Shestakova, N.N. Psychotropic Drugs for the Management of Chronic Pain and Itch. Pharmaceuticals 2019, 12, 99.

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