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Molbank, Volume 2012, Issue 4 (December 2012) – 13 articles

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Short Note
5-(tert-Butyldimethylsilyloxy)-1-(2-chloro-5,8-dimethoxyquinolin-3-yl)-3-methylenepentan-1-ol
Molbank 2012, 2012(4), M790; https://doi.org/10.3390/M790 - 14 Dec 2012
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Abstract
Novel 5-(tert-butyldimethylsilyloxy)-1-(2-chloro-5,8-dimethoxyquinolin-3-yl)-3-methylenepentan-1-ol (7) was prepared via allylation of 2-chloro-5,8-dimethoxyquinoline-3-carbaldehyde (6) with functionalized allylic iodide as tert-butyl-(3-(iodomethyl)but-3-enyloxy)dimethylsilane (5), in the presence of metallic indium in anhydrous DMF as solvent at ambient temperature. The structure of [...] Read more.
Novel 5-(tert-butyldimethylsilyloxy)-1-(2-chloro-5,8-dimethoxyquinolin-3-yl)-3-methylenepentan-1-ol (7) was prepared via allylation of 2-chloro-5,8-dimethoxyquinoline-3-carbaldehyde (6) with functionalized allylic iodide as tert-butyl-(3-(iodomethyl)but-3-enyloxy)dimethylsilane (5), in the presence of metallic indium in anhydrous DMF as solvent at ambient temperature. The structure of the synthesized compound was assigned on the basis of elemental analysis and spectral data. Full article
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2-Bromophenyl Salicylate
Molbank 2012, 2012(4), M789; https://doi.org/10.3390/M789 - 10 Dec 2012
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Abstract
2-Bromophenyl salicylate is synthesized from 2-benzyloxybenzoic acid in two steps. The final compound has been characterized by IR, 1H-NMR, 13C-NMR and HRMS. The melting point for 2-bromophenyl salicylate is provided. Full article
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1-{4-[(1-Isobutyl-1H-imidazo[4,5-c]quinolin-4yl)amino]phenyl}ethanone
Molbank 2012, 2012(4), M788; https://doi.org/10.3390/M788 - 23 Nov 2012
Cited by 3 | Viewed by 2516
Abstract
The title compound (3) is synthesized by the nucleophilic substitution of 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline 2 with 4-amino acetophenone in n-butanol. Newly prepared imiquimod derivative (3) is characterized by IR, NMR and mass spectral data. Full article
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Diethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate and Ethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Molbank 2012, 2012(4), M787; https://doi.org/10.3390/M787 - 20 Nov 2012
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Abstract
Diethyl 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine- 3,5-dicarboxylate and ethyl 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate were obtained simultaneously by the Biginelli reaction using a green protocol and curtailing reaction time. Full article
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4-{[(1-Phenyl-1H-pyrazol-3-yl)oxy]methyl}-1,3-dioxolan-2-one
Molbank 2012, 2012(4), M786; https://doi.org/10.3390/M786 - 20 Nov 2012
Cited by 2 | Viewed by 2449
Abstract
The title compound was obtained by the reaction of tosylated glycerol carbonate with 1-phenyl-1H-pyrazol-3-ol in a good 71% yield. Detailed spectroscopic data (1H-NMR, 13C-NMR, 15N-NMR, IR, MS) are presented. Full article
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4,5,6,7-Tetrachloro-2-(1H-imidazol-2-yl)isoindoline-1,3-dione
Molbank 2012, 2012(4), M785; https://doi.org/10.3390/M785 - 09 Nov 2012
Cited by 1 | Viewed by 3061
Abstract
4,5,6,7-Tetrachloro-2-(1H-imidazol-2-yl)isoindoline-1,3-dione was obtained by reaction of 2-aminoimidazole with 3,4,5,6-tetrachlorophthalic anhydride in refluxing acetic acid. Full article
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3,5-Bis(4-dodecylthiophen-2-yl)-4H-1,2,6-thiadiazin-4-one
Molbank 2012, 2012(4), M784; https://doi.org/10.3390/M784 - 08 Nov 2012
Cited by 1 | Viewed by 2208
Abstract
3,5-Dichloro-4H-1,2,6-thiadiazin-4-one 1 reacts with (4-dodecylthiophen-2-yl)trimethylstannane 4 (2.2 equiv.) and Pd(Ph3P)2Cl2 (5 mol%) in acetonitrile at ca. 82 °C to give 3,5-bis(4-dodecylthiophen-2-yl)-4H-1,2,6-thiadiazin-4-one 5 in 93% yield. Full article
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(Z)-N-(7-Cyano-9,9,15,15-tetramethyl-9,10,11,13,14,15-hexahydro-6H-benzo[4'',5'']imidazo[1'',2'':1',2']pyrido[3',4':5, 6]pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-6-ylidene)pent-4-ynamide
Molbank 2012, 2012(4), M783; https://doi.org/10.3390/M783 - 16 Oct 2012
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Abstract
Coumarin-based dye (Z)-N-(7-cyano-9,9,15,15-tetramethyl-9,10,11,13,14,15-hexahydro-6H-benzo[4'',5'']imidazo[1'',2'':1',2']pyrido[3',4':5,6]pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-6-ylidene)pent-4-ynamide (3) was obtained in 81% yield by reaction between primary imine precursor 1 and pent-4-ynoic anhydride (2) under thermal conditions. The title compound was characterized by elemental analysis, melting point, 1H-NMR, 13C-NMR, FT-IR, mass, UV-vis and fluorescence spectroscopy. Full article
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Short Note
3-Chloro-5-(4-dodecylthiophen-2-yl)-4H-1,2,6-thiadiazin-4-one
Molbank 2012, 2012(4), M782; https://doi.org/10.3390/M782 - 16 Oct 2012
Cited by 1 | Viewed by 2225
Abstract
3-Chloro-5-trifluoromethanesulfonate-4H-1,2,6-thiadiazin-4-one 3 reacts with (4-dodecylthiophen-2-yl)trimethylstannane 5 (1 equiv.) in the presence of Pd(Ph3P)2Cl2 (5 mol%) in benzene at ca. 20 °C for 5 h to give 3-chloro-5-(4-dodecylthien-2-yl)-1,2,6-thiadiazinone 6 in 87% yield. Full article
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2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV)
Molbank 2012, 2012(4), M781; https://doi.org/10.3390/M781 - 01 Oct 2012
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Abstract
An aziridine-containing side chain is attached to an oxonaphthalene-annelated pyrrole in expectation of DNA alkylating properties. The cytotoxicity is evaluated against two cell lines, KB-31 and KB-8511, respectively. Full article
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2-(4-Diethoxymethylphenyl)-6-(4-nitrophenyl)-4-phenyl-1,3-diazabicyclo[3.1.0]hex-3-ene
Molbank 2012, 2012(4), M780; https://doi.org/10.3390/M780 - 28 Sep 2012
Cited by 3 | Viewed by 2400
Abstract
The photochromic compound was obtained from 4-diethoxymethyl-benzaldehyde and trans-2-benzoyl-3-(4-nitrophenyl)aziridine via a three component reaction. The structure of this compound was characterized by elemental analysis, 1H-NMR, 13C-NMR and UV-Visible spectral data. Full article
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N1-Benzylidene-N2-(2-((2-((2-(benzylideneamino)ethyl)amino) ethyl)amino)ethyl)ethane-1,2-diamine
Molbank 2012, 2012(4), M779; https://doi.org/10.3390/M779 - 27 Sep 2012
Viewed by 2741
Abstract
A tetraethylene pentamine-diamine (L4), the biggest compound in the family of dibenzylated diimine-polyamines (L1L4) has been synthesized by classical Schiff-base reaction between benzaldehyde and the diamine tetraethylenepentamine, and the structure was confirmed [...] Read more.
A tetraethylene pentamine-diamine (L4), the biggest compound in the family of dibenzylated diimine-polyamines (L1L4) has been synthesized by classical Schiff-base reaction between benzaldehyde and the diamine tetraethylenepentamine, and the structure was confirmed by elemental analysis, ESI-MS spectrometry and by IR and 1H-NMR spectroscopy. Full article
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Short Note
2-(4-Fluoro-3-nitrophenyl)-6-(4-methoxyphenyl)imidazo[2,1-b]-1,3,4-thiadiazole
Molbank 2012, 2012(4), M778; https://doi.org/10.3390/M778 - 25 Sep 2012
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Abstract
The title compound, 2-(4-fluoro-3-nitrophenyl)-6-(4-methoxyphenyl)­imidazo[2,1-b]-1,3,4-thiadiazole (3) was obtained by the condensation of 5-(4-fluoro-3-nitrophenyl)-[1,3,4]thiadiazol-2-ylamine (1) with 4-methoxyphenacyl bromide (2). The newly prepared imidazo[2,1-b]-1,3,4-thiadiazole derivative (3) was characterized by IR, 1H-NMR, 13C-NMR and LCMS spectral data. Full article
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