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International Journal of Molecular Sciences, Volume 18, Issue 7

July 2017 - 268 articles

Cover Story: After determining the 3D structure of Littorina littorea metallothionein (Angew. Chem. Int. Ed., 2017, 56, 4617-4622) and its recognition in Science (2017, 356(6334), 150-151), in this work we analyze in depth the in vivo and in vitro metal binding capabilities of this 3-dominial metalloprotein and of two truncated mutants. We conclude that a Cd-specific metallothionein protein confers this snail a particular adaptive advantage in its changeable marine habitat. View this paper
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Articles (268)

  • Article
  • Open Access
25 Citations
7,431 Views
14 Pages

Late blight caused by Phytophthora infestans (Montagne, Bary) is a devastating disease of tomato worldwide. There are three known major genes, Ph-1, Ph-2, and Ph-3, conferring resistance to late blight. In addition to these three genes, it is also be...

  • Review
  • Open Access
83 Citations
15,554 Views
19 Pages

Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models

  • Tania Jacobo-Estrada,
  • Mitzi Santoyo-Sánchez,
  • Frank Thévenod and
  • Olivier Barbier

Even decades after the discovery of Cadmium (Cd) toxicity, research on this heavy metal is still a hot topic in scientific literature: as we wrote this review, more than 1440 scientific articles had been published and listed by the PubMed.gov website...

  • Article
  • Open Access
7 Citations
5,247 Views
12 Pages

Comparison of Two Stationary Phases for the Determination of Phytosterols and Tocopherols in Mango and Its By-Products by GC-QTOF-MS

  • Ana López-Cobo,
  • Beatriz Martín-García,
  • Antonio Segura-Carretero,
  • Alberto Fernández-Gutiérrez and
  • Ana María Gómez-Caravaca

Two different gas chromatography coupled to quadrupole-time of flight mass spectrometry (GC-QTOF-MS) methodologies were carried out for the analysis of phytosterols and tocopherols in the flesh of three mango cultivars and their by-products (pulp, pe...

  • Review
  • Open Access
59 Citations
13,858 Views
30 Pages

The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer

  • Daniela D’Arcangelo,
  • Lavinia Tinaburri and
  • Elena Dellambra

The epidermis is a self-renewing tissue. The balance between proliferation and differentiation processes is tightly regulated to ensure the maintenance of the stem cell (SC) population in the epidermis during life. Aging and cancer may be considered...

  • Article
  • Open Access
16 Citations
8,274 Views
15 Pages

Predictive Structure and Topology of Peroxisomal ATP-Binding Cassette (ABC) Transporters

  • Pierre Andreoletti,
  • Quentin Raas,
  • Catherine Gondcaille,
  • Mustapha Cherkaoui-Malki,
  • Doriane Trompier and
  • Stéphane Savary

The peroxisomal ATP-binding Cassette (ABC) transporters, which are called ABCD1, ABCD2 and ABCD3, are transmembrane proteins involved in the transport of various lipids that allow their degradation inside the organelle. Defective ABCD1 leads to the a...

  • Article
  • Open Access
9 Citations
6,510 Views
19 Pages

In vitro preservation of transgenic tomato lines overexpressing the stress-responsive transcription factor SlAREB1 was studied by using slow growth and cryopreservation techniques. Slow growth preservation was performed by using different concentrati...

  • Article
  • Open Access
1 Citations
4,044 Views
10 Pages

Lack of Association between Hepatitis C Virus core Gene Variation 70/91aa and Insulin Resistance

  • Letícia De Paula Scalioni,
  • Allan Peres Da Silva,
  • Juliana Custódio Miguel,
  • Márcia Paschoal do Espírito Santo,
  • Vanessa Alves Marques,
  • Carlos Eduardo Brandão-Mello,
  • Cristiane Alves Villela-Nogueira,
  • Lia Laura Lewis-Ximenez,
  • Elisabeth Lampe and
  • Livia Melo Villar

The role of hepatitis C virus (HCV) in insulin resistance (IR) is not fully understood. The aim of this study was to determine the impact of amino acid (aa) substitutions in the core region of HCV according to IR and to identify clinical and laborato...

  • Hypothesis
  • Open Access
2 Citations
4,394 Views
14 Pages

Parallel zippering of the SNARE domains of syntaxin 1A/B, SNAP-25, and VAMP/synaptobrevin 2 is widely regarded as supplying the driving force for exocytotic events at nerve terminals and elsewhere. However, in spite of intensive research, no consensu...

  • Review
  • Open Access
83 Citations
12,108 Views
14 Pages

Cells generate unpaired electrons, typically via oxygen- or nitrogen-based by-products during normal cellular respiration and under stressed situations. These pro-oxidant molecules are highly unstable and may oxidize surrounding cellular macromolecul...

  • Review
  • Open Access
344 Citations
16,215 Views
30 Pages

The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer

  • Dimakatso Alice Senthebane,
  • Arielle Rowe,
  • Nicholas Ekow Thomford,
  • Hendrina Shipanga,
  • Daniella Munro,
  • Mohammad A. M. Al Mazeedi,
  • Hashim A. M. Almazyadi,
  • Karlien Kallmeyer,
  • Collet Dandara and
  • Michael S. Pepper
  • + 2 authors

Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to be a challenge in cancer treatment. Chemoresistance is influenced by genetic and epigenetic alterations which affect drug uptake, metabolism and export of dru...

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Int. J. Mol. Sci. - ISSN 1422-0067