Special Issue "Free Radicals and Oxidants in Pathogenesis"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2018).
Interests: ischemia reperfusion injury; diabetes; oxidative stress; cardioprotection; reactive oxygen species; long non-coding RNA; Adiponectin; Brg1; FoxO1.
Interests: acute myocardial infarction; antioxidants; diabetes complications; blood pressure; phosphorylation; cardiac function; hypertension; pharmacology; metabolism; diabetes; oxidative stress
The interplay between free radicals and antioxidants is important in the pathogenesis of human diseases and pathologies, such as diabetes and ischemia reperfusion injury. Increases in reactive oxygen species (ROS) and reactive nitrogen species (RNS) production induce oxidative stress where antioxidants interact with free radicals to reduce oxidative stress. An imbalance between the production of ROS/RNS and antioxidant capacity leads to oxidative stress, resulting in cell/organ injury. Thus, effective means that targeting free radicals to reduce ROS/RNS and/or targeting antioxidants to increase antioxidant capacity may protect cell/organ against oxidative stress-induced damage.
We invite investigators to contribute original research articles, as well as review articles that will stimulate the continuing efforts to understand the mechanism underlying oxidative stress-induced cell/organ injury in ischemia reperfusion injury under normal and diseased conditions to develop strategies to treat these pathological conditions. Potential topics include, but are not limited to:
Roles and mechainsms of free radicals and antioxidants in organ (heart, lung, brain, liver, kidney, and/or intestine) ischemia reperfusion injury under normal and diseased conditions (e.g., diabetes and aging)
Cellular protective signaling pathways targeting free radicals and/or antioxidiants that contribute to cellular repairing during ischemia reperfusion injury and the potential interplay between them
Recent advances in preventing ischemia-reperfusion injury with a focus on oxidative stress
Prof. Dr. Zhengyuan Xia
Dr. Haobo Li
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
ischemia reperfusion injury
reactive oxygen species
reactive nitrogen species