Table of Contents
Int. J. Mol. Sci., Volume 17, Issue 1 (January 2016)
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Cover Story (view full-size image) The Helix pomatia Cd-metallothionein (HpCdMT) is a paradigmatic Cd-specific MT. This work studies [...] Read more. The Helix pomatia Cd-metallothionein (HpCdMT) is a paradigmatic Cd-specific MT. This work studies how the amino acid sequence of the linker connecting the two nine-Cys HpCdMT moieties influences its ability for metal coordination. Hence, we characterized the metal complexes yielded by two HpCdMT constructs containing longer linkers than the -KT- dipeptide of the wild type form. One mutant reproduced the linker sequence of another gastropod MT, the limpet M. crenulata, with a clear polar character; and the other derived from a plant MT (wheat Ec-1), had a clear apolar composition. Image provided by Òscar Palacios.View this article.