You are currently viewing a new version of our website. To view the old version click .

International Journal of Molecular Sciences, Volume 17, Issue 1

January 2016 - 134 articles

Cover Story: The Helix pomatia Cd-metallothionein (HpCdMT) is a paradigmatic Cd-specific MT. This work studies how the amino acid sequence of the linker connecting the two nine-Cys HpCdMT moieties influences its ability for metal coordination. Hence, we characterized the metal complexes yielded by two HpCdMT constructs containing longer linkers than the -KT- dipeptide of the wild type form. One mutant reproduced the linker sequence of another gastropod MT, the limpet M. crenulata, with a clear polar character; and the other derived from a plant MT (wheat Ec-1), had a clear apolar composition. Image provided by Òscar Palacios.View this article.
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (134)

  • Review
  • Open Access
55 Citations
9,011 Views
25 Pages

Structure Prediction: New Insights into Decrypting Long Noncoding RNAs

  • Kun Yan,
  • Yasir Arfat,
  • Dijie Li,
  • Fan Zhao,
  • Zhihao Chen,
  • Chong Yin,
  • Yulong Sun,
  • Lifang Hu,
  • Tuanmin Yang and
  • Airong Qian

Long noncoding RNAs (lncRNAs), which form a diverse class of RNAs, remain the least understood type of noncoding RNAs in terms of their nature and identification. Emerging evidence has revealed that a small number of newly discovered lncRNAs perform...

  • Article
  • Open Access
33 Citations
7,347 Views
17 Pages

Unraveling Molecular Differences of Gastric Cancer by Label-Free Quantitative Proteomics Analysis

  • Peng Dai,
  • Qin Wang,
  • Weihua Wang,
  • Ruirui Jing,
  • Wei Wang,
  • Fengqin Wang,
  • Kazem M. Azadzoi,
  • Jing-Hua Yang and
  • Zhen Yan

Gastric cancer (GC) has significant morbidity and mortality worldwide and especially in China. Its molecular pathogenesis has not been thoroughly elaborated. The acknowledged biomarkers for diagnosis, prognosis, recurrence monitoring and treatment ar...

  • Review
  • Open Access
25 Citations
9,112 Views
7 Pages

The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer

  • Mitsuru Okuno,
  • Seiji Adachi,
  • Osamu Kozawa,
  • Masahito Shimizu and
  • Ichiro Yasuda

Pancreatic cancer is one of most aggressive forms of cancer. After clinical detection it exhibits fast metastatic growth. Heat shock protein 27 (HSP27; HSPB1) has been characterized as a molecular chaperone which modifies the structures and functions...

  • Review
  • Open Access
10 Citations
7,500 Views
14 Pages

Photodynamic Therapy in Non-Gastrointestinal Thoracic Malignancies

  • Biniam Kidane,
  • Dhruvin Hirpara and
  • Kazuhiro Yasufuku

Photodynamic therapy has a role in the management of early and late thoracic malignancies. It can be used to facilitate minimally-invasive treatment of early endobronchial tumours and also to palliate obstructive and bleeding effects of advanced endo...

  • Article
  • Open Access
2 Citations
5,026 Views
12 Pages

This article focuses on correlating the column classification obtained from the method created at the Katholieke Universiteit Leuven (KUL), with the chromatographic resolution attained in biomedical separation. In the KUL system, each column is descr...

  • Review
  • Open Access
164 Citations
19,186 Views
15 Pages

The TEAD Family and Its Oncogenic Role in Promoting Tumorigenesis

  • Yuhang Zhou,
  • Tingting Huang,
  • Alfred S. L. Cheng,
  • Jun Yu,
  • Wei Kang and
  • Ka Fai To

The TEAD family of transcription factors is necessary for developmental processes. The family members contain a TEA domain for the binding with DNA elements and a transactivation domain for the interaction with transcription coactivators. TEAD protei...

  • Article
  • Open Access
17 Citations
10,395 Views
15 Pages

Animals and plants are increasingly threatened by emerging fungal and oomycete diseases. Amongst oomycetes, Saprolegnia species cause population declines in aquatic animals, especially fish and amphibians, resulting in significant perturbation in bio...

  • Review
  • Open Access
37 Citations
13,980 Views
20 Pages

An Overview of Direct Somatic Reprogramming: The Ins and Outs of iPSCs

  • Siddharth Menon,
  • Siny Shailendra,
  • Andrea Renda,
  • Michael Longaker and
  • Natalina Quarto

Stem cells are classified into embryonic stem cells and adult stem cells. An evolving alternative to conventional stem cell therapies is induced pluripotent stem cells (iPSCs), which have a multi-lineage potential comparable to conventionally acquire...

  • Review
  • Open Access
91 Citations
9,669 Views
22 Pages

Cadmium Protection Strategies—A Hidden Trade-Off?

  • Adolf Michael Sandbichler and
  • Martina Höckner

Cadmium (Cd) is a non-essential transition metal which is introduced into the biosphere by various anthropogenic activities. Environmental pollution with Cd poses a major health risk and Cd toxicity has been extensively researched over the past decad...

of 14

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Int. J. Mol. Sci. - ISSN 1422-0067