Table of Contents
Int. J. Mol. Sci., Volume 16, Issue 12 (December 2015)
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Cover Story Blood vessels are ubiquitous and one of the most important organs of all vertebrate animals, since [...] Read more. Blood vessels are ubiquitous and one of the most important organs of all vertebrate animals, since they are essential for the supply of oxygen and nutrition for the whole body through the networks. During the network formation of vascular endothelial cells, a concentration gradient of the vascular endothelial growth factor (VEGF) is considered to have a dominant effect on the morphologies of networks. On the other hand, we found that chain-like clusters are formed in absence of VEGF, and in vitro experiments revealed these clusters act as primary networks. The numerical simulations show these chain-like clusters are stabilized by the surface charges of cells, and the concentration of ions surrounding them may also be involved in this process. Image provided by Shunto Arai. View this article