Special Issue "Drug, Herb, and Dietary Supplement Hepatotoxicity"
Deadline for manuscript submissions: closed (29 February 2016)
Prof. Dr. Rolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University Frankfurt/Main, Germany
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Interests: : alcoholic liver disease; alcoholic liver injury; alcohol metabolism; microsomal ethanol-oxidizing system; drug induced liver injury; herb induced liver injury; herbal traditional Chinese medicine (TCM); dietary supplements; causality assessment
Dr. Raúl J. Andrade
Liver Unit Gastroenterology Service, Institute for Biomedical Research of Malaga (IBIMA), Virgen de la Victoria University Hospital and School of Medicine, Malaga, Spain; “Centro de Investigación Biomédica en Red de Enfermedades Digestivas y Hepáticas” (CIBERehd), Spain
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Interests: drug induced liver injury; pharmacogenomics; toxicogenomics; causality assessment; dietary supplements; regulatory issues
Drugs, herbs, and dietary supplements share the common feature of potential hepatotoxicity in a few susceptible individuals. Most of these hepatotoxic reactions are idiosyncratic and, hence, difficult to predict. Treatment commonly consists of the cessation of the incriminated product, but causality attribution may be cumbersome due to the current absence of valid diagnostic biomarkers. To aid diagnosis in hepatotoxicity cases, diagnostic tools are available, such as the CIOMS (Council for International Organization of Medical Sciences) scale, which is also called RUCAM (Rousell Uclaf Causality Assessing Method) and is based on specific diagnostic items with individual scoring, and the DILIN (Drug Induced Liver Injury Network) method, which is expert based. Whereas hepatotoxicity by synthetic drugs is fairly well recognized in clinical practice, hepatoxicity by herbs, herbal drugs, and dietary supplements are rarely suspected. The aim of this Special Issue is to provide a broad overview on these hepatotoxicity entities with their challenges and highlights. We therefore ask experts in the field to contribute their views on this emerging and fascinating topic. Since various topics are still controversial and disputed, we expect and appreciate lively discussions, in addition to well-settled issues, which are relevant to the clinical setting and require balanced statements.
Prof. Dr. Rolf Teschke
Prof. Dr. Raúl J. Andrade
Manuscript Submission Information
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- Drug induced liver injury
- Drug hepatotoxicity
- Herb induced liver injury
- Herbal hepatotoxicity
- Liver injury by dietary supplements
- Herbal traditional Chines medicine
- Dietary supplements