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Special Issue "Drug, Herb, and Dietary Supplement Hepatotoxicity"
Deadline for manuscript submissions: closed (29 February 2016).
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University Frankfurt/Main, Germany
Interests: alcoholic liver disease; alcoholic liver injury; alcohol metabolism; microsomal ethanol-oxidizing system; drug induced liver injury; herb induced liver injury; herbal traditional Chinese medicine (TCM); dietary supplements; causality assessment
Special Issues and Collections in MDPI journals
Special Issue in Medicines: Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity
Special Issue in International Journal of Molecular Sciences: Molecular Research on Drug Induced Liver Injury
Special Issue in International Journal of Molecular Sciences: Hepatotoxicity: Molecular Mechanisms and Pathophysiology
Special Issue in International Journal of Molecular Sciences: Alcoholic Liver Injury: Metabolism, Molecular Mechanisms, and Cascade of Events
Special Issue in Biomedicines: Alcoholic Liver Disease: Diagnostics and Therapeutics
Liver Unit Gastroenterology Service, Institute for Biomedical Research of Malaga (IBIMA), Virgen de la Victoria University Hospital and School of Medicine, Malaga, Spain; “Centro de Investigación Biomédica en Red de Enfermedades Digestivas y Hepáticas” (CIBERehd), Spain
Interests: drug induced liver injury; pharmacogenomics; toxicogenomics; causality assessment; dietary supplements; regulatory issues
Drugs, herbs, and dietary supplements share the common feature of potential hepatotoxicity in a few susceptible individuals. Most of these hepatotoxic reactions are idiosyncratic and, hence, difficult to predict. Treatment commonly consists of the cessation of the incriminated product, but causality attribution may be cumbersome due to the current absence of valid diagnostic biomarkers. To aid diagnosis in hepatotoxicity cases, diagnostic tools are available, such as the CIOMS (Council for International Organization of Medical Sciences) scale, which is also called RUCAM (Rousell Uclaf Causality Assessing Method) and is based on specific diagnostic items with individual scoring, and the DILIN (Drug Induced Liver Injury Network) method, which is expert based. Whereas hepatotoxicity by synthetic drugs is fairly well recognized in clinical practice, hepatoxicity by herbs, herbal drugs, and dietary supplements are rarely suspected. The aim of this Special Issue is to provide a broad overview on these hepatotoxicity entities with their challenges and highlights. We therefore ask experts in the field to contribute their views on this emerging and fascinating topic. Since various topics are still controversial and disputed, we expect and appreciate lively discussions, in addition to well-settled issues, which are relevant to the clinical setting and require balanced statements.
Prof. Dr. Rolf Teschke
Prof. Dr. Raúl J. Andrade
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Drug induced liver injury
- Drug hepatotoxicity
- Herb induced liver injury
- Herbal hepatotoxicity
- Liver injury by dietary supplements
- Herbal traditional Chines medicine
- Dietary supplements