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Int. J. Mol. Sci. 2016, 17(1), 141;

An Overview of Direct Somatic Reprogramming: The Ins and Outs of iPSCs

Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, School of Medicine, Stanford University, 257 Campus Drive, Stanford, CA 94305, USA
Dipartimento di Scienze Biomediche Avanzate, Universita’ degli Studi di Napoli Federico II, Napoli 80131, Italy
Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA
Authors to whom correspondence should be addressed.
Academic Editor: Wenbin Deng
Received: 15 December 2015 / Revised: 12 January 2016 / Accepted: 13 January 2016 / Published: 21 January 2016
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Stem cells are classified into embryonic stem cells and adult stem cells. An evolving alternative to conventional stem cell therapies is induced pluripotent stem cells (iPSCs), which have a multi-lineage potential comparable to conventionally acquired embryonic stem cells with the additional benefits of being less immunoreactive and avoiding many of the ethical concerns raised with the use of embryonic material. The ability to generate iPSCs from somatic cells provides tremendous promise for regenerative medicine. The breakthrough of iPSCs has raised the possibility that patient-specific iPSCs can provide autologous cells for cell therapy without the concern for immune rejection. iPSCs are also relevant tools for modeling human diseases and drugs screening. However, there are still several hurdles to overcome before iPSCs can be used for translational purposes. Here, we review the recent advances in somatic reprogramming and the challenges that must be overcome to move this strategy closer to clinical application. View Full-Text
Keywords: embryonic stem cells; adult stem; somatic reprogramming; induced pluripotent stem cells (iPSCs) embryonic stem cells; adult stem; somatic reprogramming; induced pluripotent stem cells (iPSCs)

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Menon, S.; Shailendra, S.; Renda, A.; Longaker, M.; Quarto, N. An Overview of Direct Somatic Reprogramming: The Ins and Outs of iPSCs. Int. J. Mol. Sci. 2016, 17, 141.

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