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Volume 17
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10.3390/ijms17010127
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Review

The Complex Relationship between Metals and Carbonic Anhydrase: New Insights and Perspectives

by
Maria Giulia Lionetto
*,
Roberto Caricato
,
Maria Elena Giordano
and
Trifone Schettino
Department of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Via Prov.le Lecce-Monteroni, 73100 Lecce, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2016, 17(1), 127; https://doi.org/10.3390/ijms17010127
Submission received: 2 December 2015 / Revised: 3 January 2016 / Accepted: 11 January 2016 / Published: 19 January 2016
(This article belongs to the Special Issue Metal Metabolism in Animals)
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Abstract

Carbonic anhydrase is a ubiquitous metalloenzyme, which catalyzes the reversible hydration of CO2 to HCO3− and H+. Metals play a key role in the bioactivity of this metalloenzyme, although their relationships with CA have not been completely clarified to date. The aim of this review is to explore the complexity and multi-aspect nature of these relationships, since metals can be cofactors of CA, but also inhibitors of CA activity and modulators of CA expression. Moreover, this work analyzes new insights and perspectives that allow translating new advances in basic science on the interaction between CA and metals to applications in several fields of research, ranging from biotechnology to environmental sciences.
Keywords: carbonic anhydrase; metals; inhibition; expression; biomarker; bioassay carbonic anhydrase; metals; inhibition; expression; biomarker; bioassay
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MDPI and ACS Style

Lionetto, M.G.; Caricato, R.; Giordano, M.E.; Schettino, T. The Complex Relationship between Metals and Carbonic Anhydrase: New Insights and Perspectives. Int. J. Mol. Sci. 2016, 17, 127. https://doi.org/10.3390/ijms17010127

AMA Style

Lionetto MG, Caricato R, Giordano ME, Schettino T. The Complex Relationship between Metals and Carbonic Anhydrase: New Insights and Perspectives. International Journal of Molecular Sciences. 2016; 17(1):127. https://doi.org/10.3390/ijms17010127

Chicago/Turabian Style

Lionetto, Maria Giulia, Roberto Caricato, Maria Elena Giordano, and Trifone Schettino. 2016. "The Complex Relationship between Metals and Carbonic Anhydrase: New Insights and Perspectives" International Journal of Molecular Sciences 17, no. 1: 127. https://doi.org/10.3390/ijms17010127

APA Style

Lionetto, M. G., Caricato, R., Giordano, M. E., & Schettino, T. (2016). The Complex Relationship between Metals and Carbonic Anhydrase: New Insights and Perspectives. International Journal of Molecular Sciences, 17(1), 127. https://doi.org/10.3390/ijms17010127

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