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Int. J. Mol. Sci. 2016, 17(1), 127;

The Complex Relationship between Metals and Carbonic Anhydrase: New Insights and Perspectives

Department of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Via Prov.le Lecce-Monteroni, 73100 Lecce, Italy
Author to whom correspondence should be addressed.
Academic Editor: Reinhard Dallinger
Received: 2 December 2015 / Revised: 3 January 2016 / Accepted: 11 January 2016 / Published: 19 January 2016
(This article belongs to the Special Issue Metal Metabolism in Animals)
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Carbonic anhydrase is a ubiquitous metalloenzyme, which catalyzes the reversible hydration of CO2 to HCO3 and H+. Metals play a key role in the bioactivity of this metalloenzyme, although their relationships with CA have not been completely clarified to date. The aim of this review is to explore the complexity and multi-aspect nature of these relationships, since metals can be cofactors of CA, but also inhibitors of CA activity and modulators of CA expression. Moreover, this work analyzes new insights and perspectives that allow translating new advances in basic science on the interaction between CA and metals to applications in several fields of research, ranging from biotechnology to environmental sciences. View Full-Text
Keywords: carbonic anhydrase; metals; inhibition; expression; biomarker; bioassay carbonic anhydrase; metals; inhibition; expression; biomarker; bioassay

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Lionetto, M.G.; Caricato, R.; Giordano, M.E.; Schettino, T. The Complex Relationship between Metals and Carbonic Anhydrase: New Insights and Perspectives. Int. J. Mol. Sci. 2016, 17, 127.

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