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Molecules, Volume 5, Issue 7 (July 2000) – 24 articles , Pages 916-991, Articles M162-M171

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Open AccessShort Note
1-(4-Nitrophenyl)-1-octyne
Molecules 2000, 5(7), M171; https://doi.org/10.3390/M171 - 30 Jul 2000
Cited by 1 | Viewed by 1877
Abstract
Following the procedure of Takahashi, et al (1), to a mixture of 1-iodo-4-nitrobenzene (7.76 mmol, 1.90g) and 1-octyne (9.3 mmol, 1.023g) in diethylamine (40 mL) are added bis[triphenylphosphine]palladium dichloride (0.2mmol, 0.14g) and copper(I) iodide (0.1mmol, 0.01g).[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
5-(2-Thienylidene)barbituric Acid
Molecules 2000, 5(7), M170; https://doi.org/10.3390/M170 - 30 Jul 2000
Viewed by 2897
Abstract
5-(2-Thienylidene)barbituric acid 3 was prepared by Knoevenagel condensation of thiophene- 2-carboxaldehyde 1 and barbituric acid 2 in ethanol using piperidine as a base [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
Trimethyl(trifluorovinyl)silane
Molecules 2000, 5(7), M169; https://doi.org/10.3390/M169 - 30 Jul 2000
Viewed by 2299
Abstract
Trimethyl(trifluorovinyl)silane was prepared [1] without characterization details from bromotrifluoroethylene, which is not commercially available.[...] Full article
Open AccessNew Book Received
Organic Synthesis on Solid Phase. By Florencio Zaragoza Dörwald
Molecules 2000, 5(7), 990-991; https://doi.org/10.3390/50700990 - 26 Jul 2000
Viewed by 2407
Abstract
Organic synthesis on solid supports is a rapidly developing methodology, which offers several advantages if compared to traditional synthesis in solution.[...] Full article
Open AccessNew Book Received
Pharmacophore Perception, Development and Use in Drug Design. Edited by Osman F. Güner
Molecules 2000, 5(7), 987-989; https://doi.org/10.3390/50700987 - 26 Jul 2000
Cited by 9 | Viewed by 3887
Abstract
The book entitiled Pharmacophore Perception, Development, and Use in Drug Design, which has been just released [1], is the first monograph dedicated to the topic of the pharmacophore.[...] Full article
Open AccessArticle
Synthesis and Antifungal Activity of Musa Phytoalexins and Structural Analogs
Molecules 2000, 5(7), 974-980; https://doi.org/10.3390/50700974 - 26 Jul 2000
Cited by 33 | Viewed by 6302
Abstract
Several perinaphthenone/phenylphenalenone compounds were synthesized to establish a relationship between structure and antifungal activity against Mycosphaerella fijiensis. Substitutions on the unsaturated carbonyl system or addition of a phenyl group reduced antibiotic activity. Full article
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Open AccessNew Book Received
Classics in Hydrocarbon Chemistry. By Henning Hopf
Molecules 2000, 5(7), 985-986; https://doi.org/10.3390/50700985 - 25 Jul 2000
Viewed by 2708
Abstract
Carbon and Hydrogen: the two basic building units can be combined in a million different ways to give a plethora of fascinating organic compounds.[...] Full article
Open AccessNew Book Received
Applied Thin-Layer Chromatography. By Elke Hahn-Deinstrop
Molecules 2000, 5(7), 983-984; https://doi.org/10.3390/50700983 - 25 Jul 2000
Viewed by 3338
Abstract
Thin layer chromatography (TLC) is a powerful, fast and inexpensive analytical method.[...] Full article
Open AccessArticle
Photolytic Cleavage and Condensation Reactions of Cyclohexa-2,4-dienones with Diamines
Molecules 2000, 5(7), 961-966; https://doi.org/10.3390/50700961 - 23 Jul 2000
Cited by 2 | Viewed by 4763
Abstract
Cyclohexa-2,4-diene-1-one sulfone derivate undergoes ring cleavage to afford bis-amides containing a diene moiety on irradiation with visible light in the presence of various diamines. Full article
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Open AccessNew Book Received
Modern Carbonyl Chemistry. Edited by Junzo Otera
Molecules 2000, 5(7), 981-982; https://doi.org/10.3390/50700981 - 20 Jul 2000
Viewed by 2481
Abstract
The carbonyl group is undoubtedly one of the most important functional groups in organic chemistry, both in its role as reactive center for synthesis or derivatisation and as crucial feature for special structural or physiological properties.[...] Full article
Open AccessArticle
Selective ipso-Nitration of tert-Butylcalix[4]arene Tripropylether
Molecules 2000, 5(7), 941-944; https://doi.org/10.3390/50700941 - 10 Jul 2000
Cited by 12 | Viewed by 4373
Abstract
An improved selective ipso-nitration of the tripropoxy derivative of tertbutylcalix[4]arene at the upper rim is described. The synthesized products are key intermediates for construction of molecular receptors based on calixarenes. Full article
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Open AccessShort Note
1-(2-Benzylaminophenyl)-2-phenylbenzimidazole
Molecules 2000, 5(7), M168; https://doi.org/10.3390/M168 - 10 Jul 2000
Viewed by 2835
Abstract
When the imine-amine compound, bis[(2-benzylideneimino)phenyl]amine [1], is heated in presence of a transition metal salt (for example FeCl3), a reaction occur leading to a new compound.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
Bis[(2-benzylideneimino)phenyl]amine
Molecules 2000, 5(7), M167; https://doi.org/10.3390/M167 - 10 Jul 2000
Viewed by 2802
Abstract
Imine and amine ligands have been widely used in the field of transition metal catalyzed olefin polymerization [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
1,2-Ethylene-bis(o-N2-phenylene-N1,N1-dimethylformamidine)
Molecules 2000, 5(7), M166; https://doi.org/10.3390/M166 - 10 Jul 2000
Viewed by 2056
Abstract
A mixture of 3.71 mmol (0.98 g) of bibenzil-2,2-di-yl-diisocyanate (1) [1] and 74.16mmol (5.42 g) of redistilled N,N-dimethylformamide (2) was refluxed under stirring for 8 h, with complete absorption of any carbon dioxide in aqueous potassium hydroxide solution [2]. Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
1,2-Ethylene-bis(p-N2-phenylene-N1,N1-dimethylformamidine)
Molecules 2000, 5(7), M165; https://doi.org/10.3390/M165 - 10 Jul 2000
Viewed by 1993
Abstract
A mixture of 4.28 mmol (1.1328 g) bibenzil-4,4-di-yl-diisocyanate (1) [1] and 84 mmol (6.14 g) of redistilled N,N-dimethylformamide (2) was refluxed under stirring using a magnetically stirring-bar for 12 h, with complete absorption for any carbon dioxide in aqueous [...] Read more.
A mixture of 4.28 mmol (1.1328 g) bibenzil-4,4-di-yl-diisocyanate (1) [1] and 84 mmol (6.14 g) of redistilled N,N-dimethylformamide (2) was refluxed under stirring using a magnetically stirring-bar for 12 h, with complete absorption for any carbon dioxide in aqueous potassium hydroxide solution [2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
6-Amino-2-phenylimidazo[4,5-e][1,3]diazepine-4,8(1H, 5H)-dione
Molecules 2000, 5(7), M164; https://doi.org/10.3390/M164 - 10 Jul 2000
Viewed by 2944
Abstract
The starting imidazole diester (1) was prepared by esterification of the corresponding dicarboxylic acid acccording to the literature procedure [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
Cycloeucalen-3ß-(2-methyl Butanoate). New Cycloeucalen Isolated from the Espeletia barclayana Cuatr (Asteraceae)
Molecules 2000, 5(7), M163; https://doi.org/10.3390/M163 - 10 Jul 2000
Cited by 1 | Viewed by 2250
Abstract
Continuing our studies of the Espeletia barclayana Cuatr.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
N-(9-Fluorenylmethoxycarbonyl)-L-serine Amide
Molecules 2000, 5(7), M162; https://doi.org/10.3390/M162 - 10 Jul 2000
Viewed by 2143
Abstract
The synthesis of N-Fmoc-L-serine amide was performed by the well known Schotten-Baumann acylation method [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessArticle
Mass Spectra of Some 4- and 5-Substituted Derivatives of Benzoselenadiazoles
Molecules 2000, 5(7), 937-940; https://doi.org/10.3390/50700937 - 09 Jul 2000
Cited by 2 | Viewed by 3999
Abstract
Electron impact mass spectra of variety of eight 4-substituted and eight 5-substituted benzoselenadiazoles are presented and their spectral fragmentations are discussed. New mass spectra containing selenium in heterocyclic azole atom containing ring. Full article
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Open AccessArticle
Three-Dimensional Quantitative Structural Activity Relationship (3D-QSAR) Studies of Some 1,5-Diarylpyrazoles: Analogue Based Design of Selective Cyclooxygenase-2 Inhibitors
Molecules 2000, 5(7), 945-955; https://doi.org/10.3390/50700945 - 08 Jul 2000
Cited by 34 | Viewed by 5646
Abstract
Selective cyclooxygenase inhibitors have attracted much attention in recent times in the design of new non-steroidal anti-inflammatory drugs (NSAID). 3D-QSAR studies have been performed on a series of 1,5-diarylpyrazoles that act as selective cyclooxygenase-2 (COX-2) inhibitors, using three different methods: comparative molecular field [...] Read more.
Selective cyclooxygenase inhibitors have attracted much attention in recent times in the design of new non-steroidal anti-inflammatory drugs (NSAID). 3D-QSAR studies have been performed on a series of 1,5-diarylpyrazoles that act as selective cyclooxygenase-2 (COX-2) inhibitors, using three different methods: comparative molecular field analysis (CoMFA) with partial least squares (PLS) fit; molecular field analysis (MFA) and; receptor surface analysis (RSA) with genetic function algorithms (GFA). The analyses were carried out on 30 analogues of which 25 were used in the training set and the rest considered for the test set. These studies produced reasonably good predictive models with high cross-validated and conventional r2 values in all the three cases. Full article
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Open AccessArticle
Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids
Molecules 2000, 5(7), 927-936; https://doi.org/10.3390/50700927 - 07 Jul 2000
Cited by 13 | Viewed by 5597
Abstract
Thiols and amines were benzamidomethylated in water solution at room temperature with (benzamidomethyl)triethylammonium chloride (1) in the presence of a small quantity of triethylamine (pH>9). Benzamidomethyl thioethers (3a-d) and (benzamidomethyl) amines or di(benzamidomethyl)amines (5) were obtained in high yields (>90%) as well as [...] Read more.
Thiols and amines were benzamidomethylated in water solution at room temperature with (benzamidomethyl)triethylammonium chloride (1) in the presence of a small quantity of triethylamine (pH>9). Benzamidomethyl thioethers (3a-d) and (benzamidomethyl) amines or di(benzamidomethyl)amines (5) were obtained in high yields (>90%) as well as S(CH2NHBz)2 in a reaction of 1 with Na2S. Benzamidomethyl esters RCOOCH2NHBz were obtained (60-75%) in reactions of carboxylic acids with 1 in chloroform or dioxane. Full article
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Open AccessArticle
Novel Behavior of Thiiranium Radical Cation Intermediates. Reactions of Dimethyl Disulfide with Alkenes in the Presence of Pd(OAc)2
Molecules 2000, 5(7), 916-926; https://doi.org/10.3390/50700916 - 07 Jul 2000
Cited by 2 | Viewed by 5702
Abstract
Reaction of dimethyl disulfide (1) with cyclohexene (2a) in AcOH in the presence of Pd(OAc)2 yields trans-1-acetoxy-2-methylcyclohexane (3a). The equivalent reactions with hex-1-ene (2b) and 2-methylpent-1-ene (2c) or 1-methylcyclohex-1-ene (2d) preferentially give anti-Markovnikov and Markovnikov adducts 4 and 3, respectively, [...] Read more.
Reaction of dimethyl disulfide (1) with cyclohexene (2a) in AcOH in the presence of Pd(OAc)2 yields trans-1-acetoxy-2-methylcyclohexane (3a). The equivalent reactions with hex-1-ene (2b) and 2-methylpent-1-ene (2c) or 1-methylcyclohex-1-ene (2d) preferentially give anti-Markovnikov and Markovnikov adducts 4 and 3, respectively, by acetoxymethylthiolation of the alkene. The Markovnikov regioselectivity 3b/4b for the reaction with 2b is higher than that for the reaction using AgOAc instead of Pd(OAc)2, which proceeds via a thiiranium ion. Addition of a polar solvent (MeCN or MeNO2) to the reactions with 2b or 2c using Pd(OAc)2 abnormally decreases the Markovnikov regioselectivity. The total yield of 3 and 4 increases with an increased concentration of AcOH. Compounds 3 and 4 are also formed and the reactions in MeCN or MeNO2 not containing AcOH. A solution of Pd(OAc)2 in 1 exhibits λmax 380 nm (log ε 3.6) assigned to the absorption of a relatively stable sulfonium salt. These indicate that the reactions using Pd(OAc)2 proceed by SN2 ringopening of a new type of thiiranium radical cations paired with −OAc via the sulfonium salts. The insensitivity of the 3/4 ratios to the reaction time at 25-60°C in the reactions with 2c-d shows the ring-opening to be controlled kinetically, but the increased ratio with reaction time at 116°C in the reaction with 2b suggests that the ring-opening is thermodynamically governed. The reaction product with 2d also undergoes a skeletal rearrangement to a thietanium radical cation to give 1-acetoxymethyl-2-methylthiocyclohexane. Full article
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Open AccessArticle
Spectral Characteristics of 2,7-Naphthyridines
Molecules 2000, 5(7), 956-960; https://doi.org/10.3390/50700956 - 27 Jun 2000
Cited by 4 | Viewed by 4076
Abstract
Substituent increments for the calculation of 1H- and 13C-NMR spectra and the MS characteristics of 2,7-naphthyridines substituted on one ring are presented. Full article
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Open AccessArticle
Reactions with Hydrazonoyl Halides. 31. Synthesis of Some New Pyrrolidino[3,4-c]pyrazolines, Pyrazoles, and Pyrazolo[3,4-d]pyridazines
Molecules 2000, 5(7), 967-973; https://doi.org/10.3390/50700967 - 21 Jun 2000
Cited by 19 | Viewed by 7263
Abstract
Pyrrolidino[3,4-c]pyrazoline and pyrazole derivatives were synthesized via reactions of a substituted hydrazonoyl bromide with N-arylmaleimides and active methylene reagents, respectively. Synthesized pyrazoles were reacted with hydrazine hydrate to give the corresponding pyrazolo[3,4-d]pyridazines. Full article
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