Molecules, Volume 26, Issue 5 (March-1 2021) – 299 articles
Cover Story (view full-size image): Boron neutron capture therapy is a promising binary therapeutic method for cancer treatment based on the capture of thermal neutrons by the 10B isotope, followed by a fission reaction resulting in high-energy α-particles and 7Li nuclei, which have a short range in biological tissues comparable to the size of cells. This allows tumor cells to be selectively destroyed without affecting the surrounding healthy tissue. The 157Gd isotope has the highest thermal neutron capture cross-section of all stable nuclides and its presence can significantly increase the effect of neutron capture therapy when a combined drug is localized near the cell nucleus. Therefore, the synthesis of a stable complex in which gadolinium is a part of a metallacarborane cluster is a real challenge for boron chemists. View this paper
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