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Molecules, Volume 26, Issue 5

March-1 2021 - 299 articles

Cover Story: Boron neutron capture therapy is a promising binary therapeutic method for cancer treatment based on the capture of thermal neutrons by the 10B isotope, followed by a fission reaction resulting in high-energy α-particles and 7Li nuclei, which have a short range in biological tissues comparable to the size of cells. This allows tumor cells to be selectively destroyed without affecting the surrounding healthy tissue. The 157Gd isotope has the highest thermal neutron capture cross-section of all stable nuclides and its presence can significantly increase the effect of neutron capture therapy when a combined drug is localized near the cell nucleus. Therefore, the synthesis of a stable complex in which gadolinium is a part of a metallacarborane cluster is a real challenge for boron chemists. View this paper
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Articles (299)

  • Article
  • Open Access
53 Citations
10,166 Views
14 Pages

Enzymatic Extraction and Characterization of Pectin from Cocoa Pod Husks (Theobroma cacao L.) Using Celluclast® 1.5 L

  • Licelander Hennessey-Ramos,
  • Walter Murillo-Arango,
  • Juliana Vasco-Correa and
  • Isabel Cristina Paz Astudillo

Cocoa pod husks are a waste generated during the processing of cocoa beans. We aimed to explore the enzymatic extraction of pectin using cellulases. The extraction process was optimized using a central composite design (CCD) and analyzed by response...

  • Article
  • Open Access
12 Citations
5,608 Views
12 Pages

Melatonin Administration Accelerates Puberty Onset in Mice by Promoting FSH Synthesis

  • Chan Yang,
  • Zaohong Ran,
  • Guoshi Liu,
  • Rong Hou,
  • Changjiu He,
  • Qinghua Liu,
  • Yingjun Chen,
  • Yuliang Liu,
  • Xiaodong Wang and
  • Chuqi Ling
  • + 2 authors

Although melatonin has been extensively studied in animal reproduction, the mechanism of melatonin in puberty remains elusive. This study was designed to explore the effect of intraperitoneal administration of melatonin on puberty onset in female mic...

  • Review
  • Open Access
185 Citations
20,879 Views
18 Pages

In this short review, we attempt to unfold various aspects of excited-state intramolecular proton transfer (ESIPT) from the studies that are available up to date. Since Weller’s discovery of ESIPT in salicylic acid (SA) and its derivative methyl sali...

  • Article
  • Open Access
14 Citations
4,028 Views
20 Pages

Dual Effect of Taxifolin on ZEB2 Cancer Signaling in HepG2 Cells

  • Zdenek Dostal,
  • Martin Sebera,
  • Josef Srovnal,
  • Katerina Staffova and
  • Martin Modriansky

Polyphenols, secondary metabolites of plants, exhibit different anti-cancer and cytoprotective properties such as anti-radical, anti-angiogenic, anti-inflammation, or cardioprotective. Some of these activities could be linked to modulation of miRNAs...

  • Review
  • Open Access
62 Citations
7,795 Views
18 Pages

Application of Light-Emitting Diodes for Improving the Nutritional Quality and Bioactive Compound Levels of Some Crops and Medicinal Plants

  • Woo-Suk Jung,
  • Ill-Min Chung,
  • Myeong Ha Hwang,
  • Seung-Hyun Kim,
  • Chang Yeon Yu and
  • Bimal Kumar Ghimire

Light is a key factor that affects phytochemical synthesis and accumulation in plants. Due to limitations of the environment or cultivated land, there is an urgent need to develop indoor cultivation systems to obtain higher yields with increased phyt...

  • Article
  • Open Access
27 Citations
5,205 Views
14 Pages

Chemical Composition of Tomato Seed Flours, and Their Radical Scavenging, Anti-Inflammatory and Gut Microbiota Modulating Properties

  • Uyory Choe,
  • Jianghao Sun,
  • Elena Bailoni,
  • Pei Chen,
  • Yanfang Li,
  • Boyan Gao,
  • Thomas T. Y. Wang,
  • Jiajia Rao and
  • Liangli (Lucy) Yu

In the current study, the chemical composition and total phenolic content of tomato seed flours, along with potential health beneficial properties, including free radical scavenging capacities, anti-inflammatory capacities, and gut microbiota profile...

  • Review
  • Open Access
3,402 Views
12 Pages

Bioconjugation has allowed scientists to combine multiple functional elements into one biological or biochemical unit. This assembly can result in the production of constructs that are targeted to a specific site or cell type in order to enhance the...

  • Article
  • Open Access
17 Citations
3,537 Views
20 Pages

Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens

  • Hazem S. Elshafie,
  • Sadeek A. Sadeek,
  • Wael A. Zordok and
  • Amira A. Mohamed

Recently, the design of new biological metal-ligand complexes has gained a special interest all over the world. In this research, new series of mixed ligand complexes from meloxicam (H2mel) and glycine (Gly) were synthesized. Structures of the compou...

  • Review
  • Open Access
16 Citations
5,442 Views
14 Pages

Conditionally activated (“caged”) oligonucleotides provide useful spatiotemporal control for studying dynamic biological processes, e.g., regulating in vivo gene expression or probing specific oligonucleotide targets. This review summarizes recent ad...

  • Article
  • Open Access
17 Citations
3,821 Views
11 Pages

Cellulose, as a natural polymer with an abundant source, has been widely used in many fields including the electric field responsive medium that we are interested in. In this work, cellulose micron particles were applied as an electrorheological (ER)...

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Molecules - ISSN 1420-3049