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Special Issue "Cyclodextrin Chemistry and Toxicology"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".

Deadline for manuscript submissions: 31 October 2020.

Special Issue Editors

Prof. Dr. Marina Isidori
Website
Guest Editor
Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy
Interests: environmental toxicology; human health; endocrine disruption activity; chemical hazards in water and food; innovative packaging
Prof. Dr. Margherita Lavorgna
Website
Guest Editor
Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy
Interests: environmental toxicology; human health; endocrine disruption activity; chemical hazards in water and food; innovative packaging
Prof. Dr. Rosa Iacovino
Website
Guest Editor
Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy
Interests: cyclodextrin; inclusion complex; preparation methods; drug delivery systems; X-ray diffraction; crystal structure

Special Issue Information

Dear Colleagues,

Cyclodextrins (CDs) are cyclic, water-soluble oligosaccharides composed of six (α-CD), seven (β-CD), or eight (γ-CD) D(+)-glucose units linked by α-1,4 bonds. Obtained from starch, CDs are considered natural molecules. Their typical toroidal-like structure consists of an apolar internal cavity and a polar external surface, allowing for the physical inclusion of a wide range of active molecules, especially with aromatic rings. Thanks to their characteristics, CDs have numerous applications in several fields, namely: biotechnologies, green chemistry, cosmetic formulations/fragrance stabilization, analytical chemistry, drug delivery, and pharmaceutical excipients. In fact, nowadays, there are already numerous food products and pharmaceutical formulations on the market containing natural CDs. To further increase the benefits of these molecules, they can undergo chemical modifications producing synthetic CD derivatives. This Special Issue aims to implement the information regarding the use of cyclodextrins and their molecular complexes, to evaluate their potential role in multiple applications.

Prof. Dr. Marina Isidori
Prof. Dr. Margherita Lavorgna
Prof. Dr. Margherita Lavorgna
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inclusion complexes
  • cyclodextrins derivates
  • biological activities
  • cyclodextrins and the improvement of theraphy efficacy
  • cyclodextrins involved in environmental remediation
  • cyclodextrins: food and innovative packaging
  • applications of cyclodextrins in cosmetic
  • cyclodextrins in textile formulations
  • cyclodextrins and controlled release of molecules included
  • nano-materials and nano-structured coatings containing cyclodextrins

Published Papers (1 paper)

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Research

Open AccessArticle
Thermodynamic Characterization of the Interaction between the Antimicrobial Drug Sulfamethazine and Two Selected Cyclodextrins
Molecules 2019, 24(24), 4565; https://doi.org/10.3390/molecules24244565 - 13 Dec 2019
Cited by 1
Abstract
Sulfamethazine is a representative member of the sulfonamide antibiotic drugs; it is still used in human and veterinary therapy. The protonation state of this drug affects its aqueous solubility, which can be controlled by its inclusion complexes with native or chemically-modified cyclodextrins. In [...] Read more.
Sulfamethazine is a representative member of the sulfonamide antibiotic drugs; it is still used in human and veterinary therapy. The protonation state of this drug affects its aqueous solubility, which can be controlled by its inclusion complexes with native or chemically-modified cyclodextrins. In this work, the temperature-dependent (298–313 K) interaction of sulfamethazine with native and randomly methylated β-cyclodextrins have been investigated at acidic and neutral pH. Surprisingly, the interaction between the neutral and anionic forms of the guest molecule and cyclodextrins with electron rich cavity are thermodynamically more favorable compared to the cationic guest. This property probably due to the enhanced formation of zwitterionic form of sulfamethazine in the hydrophobic cavities of cyclodextrins. Spectroscopic measurements and molecular modeling studies indicated the possible driving forces (hydrophobic interaction, hydrogen bonding, and electrostatic interaction) of the complex formation, and highlighted the importance of the reorganization of the solvent molecules during the entering of the guest molecule into the host’s cavity. Full article
(This article belongs to the Special Issue Cyclodextrin Chemistry and Toxicology)
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