Bioanalysis and Biological Matrix Sampling

Dear Colleagues,

Bioanalysis is one of the most stimulating and complicated fields of analytical, medicinal, and biomedical chemistry. The high complexity of matrices coming from living beings is hardly matched, and most analytes, be they endogenous or exogenous, are found in these heterogeneous matrices at extremely low levels. The intrinsic instability and ease of degradation of biomatrices only adds to the difficulty of the endeavour.

As a consequence, bioanalysis requires cutting-edge levels of sensitivity, selectivity, reproducibility, and overall reliability together with top-level throughput. To tackle these challenges effectively, a huge array of sampling, sample preparation, and analysis combinations and workflows have been devised, tested, and applied.

The results have been nothing less than amazing. Material and instrumental advances, coupled to automation, miniaturisation, and to the ingenuity and expertise of thousands of researchers, have made this field one of the most advanced, attractive, and vibrant of all analytical chemistry.

In this Special Issue, we invite researchers to contribute innovative, original research articles and reviews papers related to the state of the art of all facets of biomatrix sampling, pretreatment, and analysis. Forensic, toxicological, anti-doping, and drug analyses are among the most important, but definitely not the only, aspects of the Special Issue. Proposals including all kinds of instrumental setups, endogenous and exogenous analytes, and biological matrices are welcome.

Potential topics include, but are not limited to the following:

• Anti-doping analysis
• Clinical analysis
• Drug analysis
• Forensic analysis
• High-throughput or high-capacity analysis
• Innovation in sampling
• Sampling and microsampling
• Toxicological analysis
• Workflow and sample prep automation

Prof. Roberto Mandrioli
Prof. Dr. Laura Mercolini
Dr. Michele Protti
Guest Editors

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