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Article

Formulation of Cannabidiol in Colloidal Lipid Carriers

1
Institute of Pharmaceutical Technology and Biopharmaceutics, Technische Universität Braunschweig, Mendelssohnstraße 1, 38106 Braunschweig, Germany
2
Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany
3
Center of Pharmaceutical Engineering (PVZ), Technische Universität Braunschweig, Franz-Liszt-Straße 35a, 38106 Braunschweig, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Valentina Venuti
Molecules 2021, 26(5), 1469; https://doi.org/10.3390/molecules26051469
Received: 31 January 2021 / Revised: 28 February 2021 / Accepted: 1 March 2021 / Published: 8 March 2021
(This article belongs to the Special Issue Nanosystems in Pharmaceutical Technology)
In this study, the general processability of cannabidiol (CBD) in colloidal lipid carriers was investigated. Due to its many pharmacological effects, the pharmaceutical use of this poorly water-soluble drug is currently under intensive research and colloidal lipid emulsions are a well-established formulation option for such lipophilic substances. To obtain a better understanding of the formulability of CBD in lipid emulsions, different aspects of CBD loading and its interaction with the emulsion droplets were investigated. Very high drug loads (>40% related to lipid content) could be achieved in emulsions of medium chain triglycerides, rapeseed oil, soybean oil and trimyristin. The maximum CBD load depended on the type of lipid matrix. CBD loading increased the particle size and the density of the lipid matrix. The loading capacity of a trimyristin emulsion for CBD was superior to that of a suspension of solid lipid nanoparticles based on trimyristin (69% vs. 30% related to the lipid matrix). In addition to its localization within the lipid core of the emulsion droplets, cannabidiol was associated with the droplet interface to a remarkable extent. According to a stress test, CBD destabilized the emulsions, with phospholipid-stabilized emulsions being more stable than poloxamer-stabilized ones. Furthermore, it was possible to produce emulsions with pure CBD as the dispersed phase, since CBD demonstrated such a pronounced supercooling tendency that it did not recrystallize, even if cooled to −60 °C. View Full-Text
Keywords: cannabidiol; lipid emulsion; colloidal lipid carriers; solid lipid nanoparticles; drug localization; emulsion stability cannabidiol; lipid emulsion; colloidal lipid carriers; solid lipid nanoparticles; drug localization; emulsion stability
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MDPI and ACS Style

Francke, N.M.; Schneider, F.; Baumann, K.; Bunjes, H. Formulation of Cannabidiol in Colloidal Lipid Carriers. Molecules 2021, 26, 1469. https://doi.org/10.3390/molecules26051469

AMA Style

Francke NM, Schneider F, Baumann K, Bunjes H. Formulation of Cannabidiol in Colloidal Lipid Carriers. Molecules. 2021; 26(5):1469. https://doi.org/10.3390/molecules26051469

Chicago/Turabian Style

Francke, Nadine M., Frederic Schneider, Knut Baumann, and Heike Bunjes. 2021. "Formulation of Cannabidiol in Colloidal Lipid Carriers" Molecules 26, no. 5: 1469. https://doi.org/10.3390/molecules26051469

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