molecules-logo

Journal Browser

Journal Browser

Special Issue "Polyphenol and Its Related Compounds: Bioactivity and Molecular Mechanism"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editors

Dr. Yusaku Miyama
E-Mail Website
Guest Editor
Faculty of Life and Environmental Sciences, University of Tsukuba, Ibaraki 305-8572, Japan
Interests: chemical biology; cell biology; protein degradation; nuclear receptor; natural product chemistry
Special Issues and Collections in MDPI journals
Dr. Jun Watanabe
E-Mail Website
Co-Guest Editor
Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan
Prof. Dr. Hiroko Isoda
E-Mail Website
Co-Guest Editor
Faculty of Life and Environmental Sciences, University of Tsukuba, Ibaraki 305-8572, Japan
Interests: food functionality; bioassay; functional food; food and medicinal plants; lifestyle-related desease; natural compound drug discovery; food and health

Special Issue Information

Dear Colleagues,

Polyphenols are one of the secondary metabolites found in plants and food ingredients. Over the past 20 years, a number of studies have revealed their function on life activities, which correlates with the prevention of neurodegenerative diseases, obesity, diabetes, cancer, cardiovascular diseases, and so on. Recently, there has been a great amount of interest and various scientific advances in the molecular mechanism of these compounds, which suggests a potential of clinical application and novel biological process as well.

The Special Issue aims to collect cutting-edge studies on the bioactivity of polyphenols and their related compounds, which could contribute to the improvement of human health and disease prevention. The Special Issue is expected to examine the molecular mechanism on the basis of experimental approaches from the fields of cell biology, biochemistry, molecular biology, pharmacology, and chemical biology. Original articles and reviews in these areas are of interest.

Dr. Yusaku Miyamae
Dr. Jun Watanabe
Prof. Dr. Hiroko Isoda
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • natural products
  • bioactivity
  • mechanism of action
  • molecular target

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Open AccessArticle
Dual Effect of Taxifolin on ZEB2 Cancer Signaling in HepG2 Cells
Molecules 2021, 26(5), 1476; https://doi.org/10.3390/molecules26051476 - 09 Mar 2021
Viewed by 466
Abstract
Polyphenols, secondary metabolites of plants, exhibit different anti-cancer and cytoprotective properties such as anti-radical, anti-angiogenic, anti-inflammation, or cardioprotective. Some of these activities could be linked to modulation of miRNAs expression. MiRNAs play an important role in posttranscriptional regulation of their target genes that [...] Read more.
Polyphenols, secondary metabolites of plants, exhibit different anti-cancer and cytoprotective properties such as anti-radical, anti-angiogenic, anti-inflammation, or cardioprotective. Some of these activities could be linked to modulation of miRNAs expression. MiRNAs play an important role in posttranscriptional regulation of their target genes that could be important within cell signalling or preservation of cell homeostasis, e.g., cell survival/apoptosis. We evaluated the influence of a non-toxic concentration of taxifolin and quercetin on the expression of majority human miRNAs via Affymetrix GeneChip™ miRNA 3.0 Array. For the evaluation we used two cell models corresponding to liver tissue, Hep G2 and primary human hepatocytes. The array analysis identified four miRNAs, miR-153, miR-204, miR-211, and miR-377-3p, with reduced expression after taxifolin treatment. All of these miRNAs are linked to modulation of ZEB2 expression in various models. Indeed, ZEB2 protein displayed upregulation after taxifolin treatment in a dose dependent manner. However, the modulation did not lead to epithelial mesenchymal transition. Our data show that taxifolin inhibits Akt phosphorylation, thereby diminishing ZEB2 signalling that could trigger carcinogenesis. We conclude that biological activity of taxifolin may have ambiguous or even contradictory outcomes because of non-specific effect on the cell. Full article
Show Figures

Figure 1

Open AccessFeature PaperArticle
Antihyperuricemic Effect of Urolithin A in Cultured Hepatocytes and Model Mice
Molecules 2020, 25(21), 5136; https://doi.org/10.3390/molecules25215136 - 04 Nov 2020
Viewed by 767
Abstract
Hyperuricemia is defined as a disease with high uric acid (UA) levels in the blood and a strong risk factor for gout. Urolithin A (UroA) is a main microbial metabolite derived from ellagic acid (EA), which occurs in strawberries and pomegranates. In this [...] Read more.
Hyperuricemia is defined as a disease with high uric acid (UA) levels in the blood and a strong risk factor for gout. Urolithin A (UroA) is a main microbial metabolite derived from ellagic acid (EA), which occurs in strawberries and pomegranates. In this study, we evaluated antihyperuricemic effect of UroA in both cultured hepatocytes and hyperuricemic model mice. In cultured hepatocytes, UroA significantly and dose-dependently reduced UA production. In model mice with purine bodies-induced hyperuricemia, oral administration of UroA significantly inhibited the increase in plasma UA levels and hepatic xanthine oxidase (XO) activity. In addition, DNA microarray results exhibited that UroA, as well as allopurinol, a strong XO inhibitor, induced downregulation of the expression of genes associated with hepatic purine metabolism. Thus, hypouricemic effect of UroA could be, at least partly, attributed to inhibition of purine metabolism and UA production by suppressing XO activity in the liver. These results indicate UroA possesses a potent antihyperuricemic effect and it could be a potential candidate for a molecule capable of preventing and improving hyperuricemia and gout. Full article
Show Figures

Figure 1

Back to TopTop