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Molecules, Volume 25, Issue 2

January-2 2020 - 192 articles

Cover Story: Since the discovery of the anticancer potential of ruthenium-based complexes, several species were reported as promising candidates for the treatment of breast cancer, which accounts for the greatest number of new cases in women every year worldwide. This review of the literature aims at providing an overview of the rationally designed ruthenium-based complexes that have been reported to date for which ligands were carefully selected for the treatment of hormone-receptor-positive breast cancers (estrogen receptor (ER+) or progesterone receptor (PR+)). In addition, this brief survey highlights some of the most successful examples of ruthenium complexes reported for the treatment of triple-negative breast cancer (TNBC), a highly aggressive type of cancer. View this paper.
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Articles (192)

  • Article
  • Open Access
35 Citations
8,101 Views
11 Pages

Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation

  • Dinesh Thapa,
  • Elizabeth A. Cairns,
  • Anna-Maria Szczesniak,
  • Pushkar M. Kulkarni,
  • Alex J. Straiker,
  • Ganesh A. Thakur and
  • Melanie E. M. Kelly

20 January 2020

Cannabinoid receptor 1 (CB1) activation has been reported to reduce transient receptor potential cation channel subfamily V member 1 (TRPV1)-induced inflammatory responses and is anti-nociceptive and anti-inflammatory in corneal injury. We examined w...

  • Article
  • Open Access
11 Citations
5,011 Views
14 Pages

Analgesic, Anti-Inflammatory, Cytotoxic Activity Screening and UPLC-PDA-ESI-MS Metabolites Determination of Bioactive Fractions of Kleinia pendula

  • Mohammad Alfaifi,
  • Abdulrhman Alsayari,
  • Narasimman Gurusamy,
  • Justin Louis,
  • Serag Eldin Elbehairi,
  • Kumar Venkatesan,
  • Sivakumar Annadurai,
  • Yahya I. Asiri,
  • Ali Shati and
  • Kamel Saleh
  • + 4 authors

20 January 2020

Kleinia pendula (Forssk.) DC. is a prostrate or pendent dark green succulent herb found in the southwestern mountain regions of Saudi Arabia. The literature survey of the plant reveals a lack of phytochemical and pharmacological studies, although tra...

  • Article
  • Open Access
19 Citations
5,864 Views
22 Pages

20 January 2020

The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstit...

  • Article
  • Open Access
27 Citations
4,905 Views
15 Pages

Understanding Olive Oil Stability Using Filtration and High Hydrostatic Pressure

  • Lorenzo Guerrini,
  • Bruno Zanoni,
  • Carlotta Breschi,
  • Giulia Angeloni,
  • Piernicola Masella,
  • Luca Calamai and
  • Alessandro Parenti

20 January 2020

Veiled extra virgin olive oil (VEVOO) is very attractive on the global market. A study was performed to highlight the role of different amounts of water and microorganisms on the evolution of VEVOO quality during storage, using the selective effects...

  • Feature Paper
  • Communication
  • Open Access
11 Citations
4,670 Views
11 Pages

Cyclopentadienone Iron Tricarbonyl Complexes-Catalyzed Hydrogen Transfer in Water

  • Daouda Ndiaye,
  • Sébastien Coufourier,
  • Mbaye Diagne Mbaye,
  • Sylvain Gaillard and
  • Jean-Luc Renaud

20 January 2020

The development of efficient and low-cost catalytic systems is important for the replacement of robust noble metal complexes. The synthesis and application of a stable, phosphine-free, water-soluble cyclopentadienone iron tricarbonyl complex in the r...

  • Article
  • Open Access
29 Citations
8,160 Views
14 Pages

20 January 2020

Thrombin, a key enzyme of the serine protease superfamily, plays an integral role in the blood coagulation cascade and thrombotic diseases. In view of this, it is worthwhile to establish a method to screen thrombin inhibitors (such as natural flavono...

  • Review
  • Open Access
64 Citations
7,858 Views
23 Pages

Photochemistry of the Cloud Aqueous Phase: A Review

  • Angelica Bianco,
  • Monica Passananti,
  • Marcello Brigante and
  • Gilles Mailhot

20 January 2020

This review paper describes briefly the cloud aqueous phase composition and deeply its reactivity in the dark and mainly under solar radiation. The role of the main oxidants (hydrogen peroxide, nitrate radical, and hydroxyl radical) is presented with...

  • Article
  • Open Access
9 Citations
4,332 Views
14 Pages

20 January 2020

The abiotic photochemical reactions that take place naturally in sunlit surface waters can degrade many contaminants that pose concern to water bodies for their potentially toxic and long-term effects. This works aims at assessing the ability of Euro...

  • Article
  • Open Access
12 Citations
4,574 Views
15 Pages

Characterization of Eucalyptus nitens Lignins Obtained by Biorefinery Methods Based on Ionic Liquids

  • Lucía Penín,
  • Heiko Lange,
  • Valentín Santos,
  • Claudia Crestini and
  • Juan Carlos Parajó

20 January 2020

Eucalyptus nitens wood samples were subjected to consecutive stages of hydrothermal processing for hemicellulose solubilization and delignification with an ionic liquid, i.e., either 1-butyl-3-methylimidazolium hydrogen sulfate or triethylammonium hy...

  • Article
  • Open Access
45 Citations
7,672 Views
15 Pages

Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism

  • Hanan A. Bashmail,
  • Aliaa A. Alamoudi,
  • Abdulwahab Noorwali,
  • Gehan A. Hegazy,
  • Ghada M. Ajabnoor and
  • Ahmed M. Al-Abd

20 January 2020

Thymoquinone (TQ) has shown substantial evidence for its anticancer effects. Using human breast cancer cells, we evaluated the chemomodulatory effect of TQ on paclitaxel (PTX). TQ showed weak cytotoxic properties against MCF-7 and T47D breast cancer...

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Molecules - ISSN 1420-3049