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Open AccessReview

Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry

1
Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50 370 Wrocław, Poland
2
Faculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie St., 50 383 Wrocław, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: Zbigniew Czarnocki and Joanna Szawkało
Molecules 2020, 25(2), 401; https://doi.org/10.3390/molecules25020401
Received: 29 December 2019 / Revised: 14 January 2020 / Accepted: 16 January 2020 / Published: 18 January 2020
(This article belongs to the Special Issue Stereochemistry in Action)
For almost 20 years, thioureas have been experiencing a renaissance of interest with the emerged development of asymmetric organocatalysts. Due to their relatively high acidity and strong hydrogen bond donor capability, they differ significantly from ureas and offer, appropriately modified, great potential as organocatalysts, chelators, drug candidates, etc. The review focuses on the family of chiral thioureas, presenting an overview of the current state of knowledge on their synthesis and selected applications in stereoselective synthesis and drug development. View Full-Text
Keywords: asymmetric synthesis; chirality; isothiocyanates; organocatalysis; stereoselectivity; thioureas asymmetric synthesis; chirality; isothiocyanates; organocatalysis; stereoselectivity; thioureas
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MDPI and ACS Style

Steppeler, F.; Iwan, D.; Wojaczyńska, E.; Wojaczyński, J. Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry. Molecules 2020, 25, 401. https://doi.org/10.3390/molecules25020401

AMA Style

Steppeler F, Iwan D, Wojaczyńska E, Wojaczyński J. Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry. Molecules. 2020; 25(2):401. https://doi.org/10.3390/molecules25020401

Chicago/Turabian Style

Steppeler, Franz; Iwan, Dominika; Wojaczyńska, Elżbieta; Wojaczyński, Jacek. 2020. "Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry" Molecules 25, no. 2: 401. https://doi.org/10.3390/molecules25020401

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