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Special Issue "Total Synthesis of Natural Products: A Themed Issue Dedicated to Professor Dr. Dieter Schinzer for His 65th Birthday"
Deadline for manuscript submissions: 31 October 2019.
Professor Dr. Dieter Schinzer, born 7 July, 1953 in Gudensberg, Germany, obtained his undergraduate education at the University of Marburg (1974–1977), whereafter he carried out his graduate studies at the University of Bonn under the supervision of Professor Manfred T. Reetz. In 1980, having obtained his PhD, he spent two years as a Feodor-Lynen post-doctoral fellow at the University of California, Berkeley in the research group of professor Clayton Heathcock. Upon returning to Germany, he obtained a Liebig fellowship and, at the Leibniz University of Hannover, finished his habilitation in 1986 with Professor Ekkehardt Winterfeldt. After another three years at Hannover as a Heisenberg fellow, Dr. Schinzer spent a year at the University of Göttingen (as the Schöllkopf Chair) followed by a period as a Visiting Professor at the University of Wisconsin, USA. In 1990 he was appointed Associate Professor of Chemistry at the Technical University of Braunschweig before receiving a full professorship for the Otto-von-Guericke University of Magdeburg Institute of Chemistry in 1997, his current position. Here he served as the Dean of the Faculty of Chemical Engineering from 2002 to 2005.
Despite his wide research interests in organometallic chemistry (especially silicon, tin and manganese), synthetic methodology and medicinal chemistry, Dr. Schinzer is first and foremost a devoted natural product chemist. In 1997, his research group was among the first to achieve the total synthesis of epothilones. His interest in medicinal chemistry led him to be a founder and CSO of MOLISA (Molecular Links Sachsen-Anhalt GmbH) in 2002. He was then instrumental in developing several European COST research consortia under the general umbrella of Bioactive Natural Product synthesis. He also served as the Chairman of the COST Domain Committee for Chemistry and Molecular Sciences from 2006 to 2009.
Molecules is pleased to announce a Special Issue honoring Dr. Dieter Schinzer, on the occasion of his 65th birthday, for his outstanding achievements in natural product chemistry. This Special Issue is dedicated to all aspects of natural product chemistry, in particular total synthesis, but, following the interests of Dr. Schinzer, contributions related to isolation and structure elucidation, as well as drug design based on natural product leads, their computer aided methods and structure-activity relationships (SAR), are welcome.
It is a pleasure to invite you to submit a manuscript to this Special Issue. Regular articles, communications, and reviews are all welcome.
Prof. Dr. Ari Koskinen
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Natural products
- Total synthesis
- Bioinspired drug design
- Structure elucidation
- Structure–activity relationships
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Author: Martin Cordes and Markus Kalesse
Institute of Organic Chemistry, Gottfried Wilhelm Leibniz University of Hannover, Schneiderberg 1b,
6 30167 Hannover, Germany
Paper type: Review
Tentative Title: Very Recent Advances in Vinylogous Mukaiyama Aldol Reactions and Their Applications to Synthesis
Tentative abstract: It is a challenging objective in synthetic organic chemistry to create efficient access to biologically active compounds. In particular, one structural element which is frequently incorporated in the framework of complex natural products is a β-hydroxy ketone. In this context, the aldol reaction as the most important transformation to generate this structural element not only creates new C–C bonds but also establishes stereogenic centers. In recent years, a large variety of highly selective methodologies of aldol and aldol-type reactions had been put forward. On this background, the vinylogous Mukaiyama aldol reaction (here and hereafter VMAR) became a pivotal transformation since it allows the synthesis of larger fragments while incorporating 1,5-relationships and generating two new stereocenters and one double bond simultaneously. This review summarizes and updates methodology-oriented and target-oriented researches focused on the various aspects of the VMA reaction. The manuscript comprehensively condenses the last four
20 years of research, covering the period 2016–2019.
Author: Kenichi Kobayashi, Risako Kunimura, and Hiroshi Kogen
Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan
Paper type: Communication
Tentative Title: Total synthesis of the proposed structure of paraphaeosphaeride C
Tentative abstract: Paraphaeosphaeride C is a nitrogen-containing bicyclic natural product with STAT3 inhibitory activity, which is a demethoxy derivative of phaeosphaeride A. In our previous papers, we reported the total synthesis of phaeosphaeride A by a diastereoselective vinyl anion aldol reaction as a key step to construct a dihydropyran ring. In this work, the first total synthesis of the proposed structure of paraphaeosphaeride C was achieved by a similar synthetic strategy to that used for phaeosphaeride A. The synthetic compound was characterized through extended NMR analysis, however, 1H and 13C NMR data for this compound did not correspond to those reported in the literature for paraphaeosphaeride C.