Table of Contents
Molecules, Volume 23, Issue 10 (October 2018)
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Cover Story (view full-size image) The sweet receptor recognizes all known artificial and natural sweeteners. To measure productive [...] Read more. The sweet receptor recognizes all known artificial and natural sweeteners. To measure productive ligand binding modes, the ATD of the T1R2 sweet-receptor protein was isolated in the dimeric form for multimodal, high-throughput biophysical assays to monitor ligand binding, receptor stability, and conformational changes for functional studies. Our platform, which uses complementary NMR-STD and biophysical analyses, is advantageous for studying the mechanism of ligand binding and signaling processes in other GPCRs. View the paper here.