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Molecules, Volume 22, Issue 9 (September 2017)
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Cover Story (view full-size image) Treating complex diseases, such as cancer, relies on interfering with a network of different target [...] Read more. Treating complex diseases, such as cancer, relies on interfering with a network of different target proteins. Within the family of matrix metalloproteinases (MMPs), several targets and anti-targets have been identified over decades of research. The time is ripe for developing small molecule inhibitors acting on several target proteins simultaneously, while leaving the anti-targets alone. A selective MMP-7/-13 small molecule inhibitor with precisely such an inhibition profile has now been developed. View Paper here