Special Issue "Synthesis and Modification of Natural Product"
Deadline for manuscript submissions: closed (15 May 2017)
Natural products remain an enduring and vital starting point to discover lead compounds for the development of new therapeutic agents due to the very large diversity of their structures and various biological activities. An analysis of the sources of new drugs from 1981–2010 indicated that only 36% of new chemical entities were discovered without inspiration from a natural product. However, most of the natural products cannot be applied as drugs because of their low efficacy, toxic and side effect, and bad physicochemical properties. Chemical modifications are often required in order to improve their therapeutic potential, reduce their toxicities and tailor their physicochemical properties. It also generates derivatives for structure-activity relationship (SAR) studies which play a very important role in drug design.
Additionally, natural products obtained from separation are usually less efficient because it is time consuming and complicated, and the yield is low. In this regard, semi- and total synthesis of natural products may exert their advantages with the development of many new synthetic methodologies. On the other hand, natural products synthesis is one of the most important research areas of organic chemistry, and is the fusion of art and science on the molecular level. Total synthesis of natural products not only has important theoretical and practical significance for the development of the chemistry itself, but also has a positive strategic significance to improve the capability of independent innovation in drug development, to protect the ecological resource and the environment, and to train professional organic chemists.
This Special Issue will focus on the structure modification and semi or total synthesis of natural products. In addition to original research articles, review articles are also welcome^.
Prof. Dr. Qing-Wen Zhang
Prof. Dr. Chuang-Chuang Li
Manuscript Submission Information
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- Natural products modification
- Natural products synthesis
- Drug discovery