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Molecules, Volume 21, Issue 5

May 2016 - 139 articles

Cover Story: Carbohydrates form the third alphabet of life, and their oligomers (glycans) are integral components of cellular glycoconjugates. By acting as counterreceptors for tissue lectins, they are increasingly delineated to affect diverse aspects of cell physiology. In addition to the glycans’ structure, the topology of their presentation is a factor for affinity to lectins. The importance of this is currently not properly understood but can be unraveled by designing chemical tools to help characterize structure–activity relationships, spanning the range from monovalent derivatives to glycoclusters and glycodendrimers, as well as biomimetic surfaces. Taking adhesion/growth-regulatory galectins as an instructive example, the concept and experimental proofs are presented on this functional pairing. View the paper
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Articles (139)

  • Article
  • Open Access
8 Citations
6,019 Views
12 Pages

A Convenient Synthesis of 3,7′-Bisindole Derivatives

  • Teng Liu,
  • Hong-You Zhu,
  • Da-Yun Luo,
  • Sheng-Jiao Yan and
  • Jun Lin

An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-die...

  • Article
  • Open Access
39 Citations
8,395 Views
20 Pages

Ethyl Acetate Abatement on Copper Catalysts Supported on Ceria Doped with Rare Earth Oxides

  • Sónia Alexandra Correia Carabineiro,
  • Michalis Konsolakis,
  • George Emmanouil-Nontas Marnellos,
  • Muhammad Faizan Asad,
  • Olívia Salomé Gonçalves Pinto Soares,
  • Pedro Bandeira Tavares,
  • Manuel Fernando Ribeiro Pereira,
  • José Joaquim de Melo Órfão and
  • José Luís Figueiredo

Different lanthanide (Ln)-doped cerium oxides (Ce0.5Ln0.5O1.75, where Ln: Gd, La, Pr, Nd, Sm) were loaded with Cu (20 wt. %) and used as catalysts for the oxidation of ethyl acetate (EtOAc), a common volatile organic compound (VOC). For comparison, b...

  • Review
  • Open Access
18 Citations
6,923 Views
10 Pages

Taxanes in the Treatment of Advanced Gastric Cancer

  • Byung Woog Kang,
  • Oh-Kyoung Kwon,
  • Ho Young Chung,
  • Wansik Yu and
  • Jong Gwang Kim

Although rapid advances in treatment options have improved the prognosis of advanced gastric cancer (AGC), it remains a major public health problem and the second leading cause of cancer-related deaths in the world. Taxanes (paclitaxel and docetaxel)...

  • Communication
  • Open Access
16 Citations
9,051 Views
9 Pages

Regioselective Benzoylation of Diols and Carbohydrates by Catalytic Amounts of Organobase

  • Yuchao Lu,
  • Chenxi Hou,
  • Jingli Ren,
  • Xiaoting Xin,
  • Hengfu Xu,
  • Yuxin Pei,
  • Hai Dong and
  • Zhichao Pei

A novel metal-free organobase-catalyzed regioselective benzoylation of diols and carbohydrates has been developed. Treatment of diol and carbohydrate substrates with 1.1 equiv. of 1-benzoylimidazole and 0.2 equiv. of 1,8-diazabicyclo[5.4.0]undec-7-en...

  • Article
  • Open Access
49 Citations
8,342 Views
16 Pages

De Novo Sequencing and Transcriptome Analysis of Pleurotus eryngii subsp. tuoliensis (Bailinggu) Mycelia in Response to Cold Stimulation

  • Yong-Ping Fu,
  • Yuan Liang,
  • Yue-Ting Dai,
  • Chen-Tao Yang,
  • Ming-Zheng Duan,
  • Zhuo Zhang,
  • Song-Nian Hu,
  • Zhi-Wu Zhang and
  • Yu Li

Cold stimulation of Bailinggu’s mycelia is the main factor that triggers primordia initiation for successful production of fruiting bodies under commercial cultivation. Yet, the molecular-level mechanisms involved in mycelia response to cold stimulat...

  • Review
  • Open Access
34 Citations
8,292 Views
11 Pages

Various microorganisms have been widely applied in nutraceutical industries for the processing of phytochemical conversion. Specifically, in the Asian food industry and academia, notable attention is paid to the biocatalytic process of ginsenosides (...

  • Article
  • Open Access
3 Citations
5,942 Views
9 Pages

Regioselective Palmitoylation of 9-(2,3-Dihydroxy- propyl)adenine Catalyzed by a Glycopolymer-enzyme Conjugate

  • Jana Brabcová,
  • Jiří Blažek,
  • Marcela Krečmerová,
  • Jiří Vondrášek,
  • Jose M. Palomo and
  • Marie Zarevúcka

The enzymatic regioselective monopalmitoylation of racemic 9-(2,3-dihydroxypropyl)- adenine (DHPA), an approved antiviral agent, has been performed by an immobilized form of Candida antarctica B lipase (CAL-B) using a 4:1 DMF/hexane mixture as the re...

  • Article
  • Open Access
17 Citations
7,074 Views
16 Pages

Naturally Inspired Molecules as Multifunctional Agents for Alzheimer’s Disease Treatment

  • Angela Rampa,
  • Andrea Tarozzi,
  • Francesca Mancini,
  • Letizia Pruccoli,
  • Rita Maria Concetta Di Martino,
  • Silvia Gobbi,
  • Alessandra Bisi,
  • Angela De Simone,
  • Francesco Palomba and
  • Nelsi Zaccheroni
  • + 1 author

Alzheimer’s disease (AD) has been defined as a multi-factorial disorder resulting from a complex array of networked cellular and molecular mechanisms. In particular, elevated levels of Aβ protein and its aggregation products in the presence of metal...

  • Article
  • Open Access
35 Citations
8,784 Views
20 Pages

Trametes pubescens, white rot fungus, has been used for folk medicine in Asian countries to treat ailments such as cancer and gastrointestinal diseases. This study was initiated to evaluate the in vitro antioxidant, anti-diabetes, anti-dementia, and...

  • Article
  • Open Access
73 Citations
8,691 Views
18 Pages

Reversible Immobilization of Lipases on Heterofunctional Octyl-Amino Agarose Beads Prevents Enzyme Desorption

  • Nazzoly Rueda,
  • Tiago L. Albuquerque,
  • Rocio Bartolome-Cabrero,
  • Laura Fernandez-Lopez,
  • Rodrigo Torres,
  • Claudia Ortiz,
  • Jose C. S. Dos Santos,
  • Oveimar Barbosa and
  • Roberto Fernandez-Lafuente

Two different heterofunctional octyl-amino supports have been prepared using ethylenediamine and hexylendiamine (OCEDA and OCHDA) and utilized to immobilize five lipases (lipases A (CALA) and B (CALB) from Candida antarctica, lipases from Thermomyces...

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Molecules - ISSN 1420-3049