You are currently viewing a new version of our website. To view the old version click .

Molecules, Volume 21, Issue 4

April 2016 - 149 articles

Cover Story: With its epidemic proportion and an attrition rate approaching 100%, Alzheimer’s disease (AD) is an extremely frustrating drug discovery field. Unlike many other major diseases, no medicine has been found to cure or even slow the course of AD. Recently, a small ray of hope has broken through the gloomy outcomes associated with AD: the development of the so-called multitarget drugs. These are single molecules which, acting simultaneously on different pharmacological targets of the disease network, are inherently more adequate to confront AD complex brain pathology. In this issue, Maria Laura Bolognesi, University of Bologna, Italy, and colleagues argue in support of a multitarget drug discovery strategy as a powerful way to develop new, effective, anti-AD drugs. At the same time, they also warn that challenges remain and there is much to learn as we embark on this journey to move them from bench to bedside. View the paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (149)

  • Article
  • Open Access
41 Citations
10,687 Views
14 Pages

Breast Cancer Stem Cell Culture and Enrichment Using Poly(ε-Caprolactone) Scaffolds

  • Sònia Palomeras,
  • Marc Rabionet,
  • Inés Ferrer,
  • Ariadna Sarrats,
  • Maria Luisa Garcia-Romeu,
  • Teresa Puig and
  • Joaquim Ciurana

The cancer stem cell (CSC) population displays self-renewal capabilities, resistance to conventional therapies, and a tendency to post-treatment recurrence. Increasing knowledge about CSCs’ phenotype and functions is needed to investigate new therape...

  • Review
  • Open Access
34 Citations
8,678 Views
24 Pages

Bifunctional Phosphorus Dendrimers and Their Properties

  • Anne-Marie Caminade and
  • Jean-Pierre Majoral

Dendrimers are hyperbranched and monodisperse macromolecules, generally considered as a special class of polymers, but synthesized step-by-step. Most dendrimers have a uniform structure, with a single type of terminal function. However, it is often d...

  • Article
  • Open Access
60 Citations
9,648 Views
13 Pages

We previously reported that the citrus flavonoid 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF) increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of a transient global ischemia mouse model. Since the BDNF hypothesis o...

  • Article
  • Open Access
22 Citations
10,828 Views
10 Pages

Highly Efficient Reproducible Perovskite Solar Cells Prepared by Low-Temperature Processing

  • Hao Hu,
  • Ka Kan Wong,
  • Tom Kollek,
  • Fabian Hanusch,
  • Sebastian Polarz,
  • Pablo Docampo and
  • Lukas Schmidt-Mende

In this work, we describe the role of the different layers in perovskite solar cells to achieve reproducible, ~16% efficient perovskite solar cells. We used a planar device architecture with PEDOT:PSS on the bottom, followed by the perovskite layer a...

  • Article
  • Open Access
12 Citations
11,647 Views
10 Pages

Crystallization of Esomeprazole Magnesium Water/Butanol Solvate

  • Jenna Skieneh,
  • Bahareh Khalili Najafabadi,
  • Stephen Horne and
  • Sohrab Rohani

The molecular structure of esomeprazole magnesium derivative in the solid-state is reported for the first time, along with a simplified crystallization pathway. The structure was determined using the single crystal X-ray diffraction technique to reve...

  • Article
  • Open Access
29 Citations
7,409 Views
13 Pages

Despite the available chemotherapy and treatment, leukemia remains a difficult disease to cure due to frequent relapses after treatment. Among the heterogeneous leukemic cells, a rare population referred as the leukemic stem cell (LSC), is thought to...

  • Article
  • Open Access
11 Citations
6,267 Views
7 Pages

The weevil Aegorhinus superciliosus Guérin (Coleoptera: Curculionidae), which is endemic to Central-Southern Chile and Argentina, is one of the major berry pests in Chile and the most important pest in the La Araucanía Region (38°44′9″S, 72°35′25″W)....

of 15

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Molecules - ISSN 1420-3049