Next Article in Journal
Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice
Next Article in Special Issue
Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012
Previous Article in Journal
Developing an Absorption–Based Quality Control Method for Hu–Gan–Kang–Yuan Capsules by UFLC–QTOF–MS/MS Screening and HPLC–DAD Quantitative Determination
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Molecules 2016, 21(5), 580;

MRI Reporter Genes for Noninvasive Molecular Imaging

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Zhen Cheng
Received: 10 March 2016 / Revised: 21 April 2016 / Accepted: 25 April 2016 / Published: 18 May 2016
(This article belongs to the Special Issue Molecular Imaging Probes)
Full-Text   |   PDF [3869 KB, uploaded 18 May 2016]   |  


Magnetic resonance imaging (MRI) is one of the most important imaging technologies used in clinical diagnosis. Reporter genes for MRI can be applied to accurately track the delivery of cell in cell therapy, evaluate the therapy effect of gene delivery, and monitor tissue/cell-specific microenvironments. Commonly used reporter genes for MRI usually include genes encoding the enzyme (e.g., tyrosinase and β-galactosidase), the receptor on the cells (e.g., transferrin receptor), and endogenous reporter genes (e.g., ferritin reporter gene). However, low sensitivity limits the application of MRI and reporter gene-based multimodal imaging strategies are common including optical imaging and radionuclide imaging. These can significantly improve diagnostic efficiency and accelerate the development of new therapies. View Full-Text
Keywords: reporter gene; MRI; molecular imaging; multimodal imaging reporter gene; MRI; molecular imaging; multimodal imaging

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Yang, C.; Tian, R.; Liu, T.; Liu, G. MRI Reporter Genes for Noninvasive Molecular Imaging. Molecules 2016, 21, 580.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top