Biofabrication Technologies for Tissue Repair and Regeneration

Dear Colleagues,

Recent breakthroughs in biofabrication are transforming the field of tissue repair and regeneration through the creation of biomimetic constructs that replicate the complexity of native tissue. Advanced techniques—particularly 3D bioprinting, alongside unidirectional freeze-drying, electrospinning, and two-photon lithography—now enable precise control over cell placement, matrix composition, and bioactive cues, producing architectures with tailored mechanical, biochemical, and electrical properties.

The integration of stimuli-responsive nanomaterials, including piezoelectric, plasmonic, and magneto-responsive systems, adds dynamic functionality, converting external stimuli into biochemical signals that regulate cell behavior, modulate inflammation, and accelerate tissue regeneration. This synergy between high-resolution bioprinting and smart nanomaterials is paving the way for adaptive scaffolds capable of on-demand drug delivery, mechanical actuation, and localized bioelectrical stimulation.

This Topic aims to collate cutting-edge research at the intersection of additive manufacturing and stimuli-responsive biomaterials, highlighting the next generation of active, patient-specific constructs poised to redefine regenerative medicine.

Dr. Lorenzo Vannozzi
Dr. Eugenio Redolfi Riva
Topic Editors