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12 Results Found

  • Review
  • Open Access
3 Citations
2,701 Views
14 Pages

Unveiling the Molecular Mechanisms Underlying the Success of Simple Limbal Epithelial Transplantation (SLET)

  • Aastha Garg,
  • Kartik Goel,
  • Abha Gour,
  • Mehak Sapra,
  • Virender Singh Sangwan,
  • Ratnakar Tripathi and
  • Anil Tiwari

29 January 2025

Simple limbal epithelial transplantation (SLET) has emerged as an effective treatment option for limbal stem cell deficiency (LSCD). However, the precise molecular mechanisms underlying its success remain incompletely understood. This review delves i...

  • Article
  • Open Access
13 Citations
3,871 Views
15 Pages

In Vivo Confocal Microscopy of the Corneal-Conjunctival Transition in the Evaluation of Epithelial Renewal after SLET

  • Emilio Pedrotti,
  • Chiara Chierego,
  • Tiziano Cozzini,
  • Tommaso Merz,
  • Neil Lagali,
  • Alessandra De Gregorio,
  • Adriano Fasolo,
  • Erika Bonacci,
  • Jacopo Bonetto and
  • Giorgio Marchini

6 November 2020

Examination of the corneal surface by in vivo confocal microscopy (IVCM) allows for objective identification of corneal and conjunctival cell phenotypes to evaluate different epithelialization patterns. Detection of a corneal-conjunctival epithelial...

  • Article
  • Open Access
1,244 Views
8 Pages

11 July 2025

Limbal dermoids are congenital, benign, choristomatous growths affecting the corneal-limbal junction. Conventional excision techniques often result in persistent epithelial defects, corneal thinning, and vascularization due to sectoral limbal stem ce...

  • Review
  • Open Access
383 Views
14 Pages

1 February 2026

Background: Cultivated oral mucosal epithelial transplantation (COMET/CAOMECS) is an autologous, immunosuppression-sparing option for ocular surface reconstruction in limbal stem cell deficiency (LSCD). After two decades, indications, platforms and o...

  • Article
  • Open Access
1,136 Views
20 Pages

19 August 2025

Mild–moderate equine asthma (MEA) is a very common but underdiagnosed pulmonary disease in horses, with mild cases not showing clinical respiratory signs. This study evaluates the influence of a standardized lunging exercise test (SLET) on bron...

  • Article
  • Open Access
2 Citations
2,402 Views
17 Pages

The Effect of Endurance Training on Pulmonary V˙O2 Kinetics in Solid Organs Transplanted Recipients

  • Alessio del Torto,
  • Carlo Capelli,
  • Roberto Peressutti,
  • Adriana Di Silvestre,
  • Ugolino Livi,
  • Chiara Nalli,
  • Sandro Sponga,
  • Giampaolo Amici,
  • Umberto Baccarani and
  • Stefano Lazzer

Background: We investigated the effects of single (SL-ET) and double leg (DL-ET) high-intensity interval training on O2 deficit (O2Def) and mean response time (MRT) during square-wave moderate-intensity exercise (DL-MOD), and on the amplitude of V...

  • Article
  • Open Access
7 Citations
4,140 Views
30 Pages

Limits on Magnetized Quark-Nugget Dark Matter from Episodic Natural Events

  • J. Pace VanDevender,
  • Aaron P. VanDevender,
  • Peter Wilson,
  • Benjamin F. Hammel and
  • Niall McGinley

4 February 2021

A quark nugget is a hypothetical dark-matter candidate composed of approximately equal numbers of up, down, and strange quarks. Most models of quark nuggets do not include effects of their intrinsic magnetic field. However, Tatsumi used a mathematica...

  • Article
  • Open Access
9 Citations
3,391 Views
28 Pages

Results of Search for Magnetized Quark-Nugget Dark Matter from Radial Impacts on Earth

  • J. Pace VanDevender,
  • Robert G. Schmitt,
  • Niall McGinley,
  • David G. Duggan,
  • Seamus McGinty,
  • Aaron P. VanDevender,
  • Peter Wilson,
  • Deborah Dixon,
  • Helen Girard and
  • Jacquelyn McRae

21 April 2021

Magnetized quark nuggets (MQNs) are a recently proposed dark-matter candidate consistent with the Standard Model and with Tatsumi’s theory of quark-nugget cores in magnetars. Previous publications have covered their formation in the early universe, a...

  • Article
  • Open Access
937 Views
18 Pages

Linking Elastin in Skeletal Muscle Extracellular Matrix to Metabolic and Aerobic Function in Type 2 Diabetes: A Secondary Analysis of a Lower Leg Training Intervention

  • Nicholas A. Hulett,
  • Leslie A. Knaub,
  • Irene E. Schauer,
  • Judith G. Regensteiner,
  • Rebecca L. Scalzo and
  • Jane E. B. Reusch

2 October 2025

Background: Type 2 diabetes (T2D) is associated with reduced cardiorespiratory fitness (CRF), a critical predictor of cardiovascular disease and all-cause mortality. CRF relies upon the coordinated action of multiple systems including the skeletal mu...

  • Article
  • Open Access
10 Citations
7,726 Views
22 Pages

Diagnostic Algorithm for Surgical Management of Limbal Stem Cell Deficiency

  • Boris Malyugin,
  • Svetlana Kalinnikova,
  • Ruslan Isabekov,
  • Dmitriy Ostrovskiy,
  • Boris Knyazer and
  • Maxim Gerasimov

Background: Limbal stem cell deficiency (LCSD) presents several challenges. Currently, there is no clearly defined systematic approach to LSCD diagnosis that may guide surgical tactics. Methods: The medical records of 34 patients with LSCD were analy...

  • Review
  • Open Access
6 Citations
3,637 Views
24 Pages

The future of eye reconstruction invariably includes stem cells transplantation. Corneal limbus, corneal stroma, trabeculum, retinal cells, optic nerve, and all structures that are irreversibly damaged and have no means to be repaired or replaced, th...