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25 Results Found

  • Communication
  • Open Access
2 Citations
2,585 Views
7 Pages

6 October 2022

Retinal laser therapy such as panretinal photocoagulation can be associated with complications, including rare cases of choroidal detachment. This report describes high-resolution optical coherence tomography (OCT) imaging after retinal laser panreti...

  • Review
  • Open Access
6 Citations
3,977 Views
17 Pages

Proliferative diabetic retinopathy (PDR) poses a significant therapeutic problem that often results in severe visual loss. Panretinal photocoagulation (PRP) has long been a mainstay treatment for this condition. Conversely, intravitreal anti-VEGF the...

  • Article
  • Open Access
4 Citations
3,509 Views
9 Pages

Morphological Changes in the Foveal Avascular Zone after Panretinal Photocoagulation for Diabetic Retinopathy Using OCTA: A Study Focusing on Macular Ischemia

  • Ken Hoshiyama,
  • Takao Hirano,
  • Kazutaka Hirabayashi,
  • Masumi Wakabayashi,
  • Motoharu Tokimitsu and
  • Toshinori Murata

6 December 2022

Background and objectives: This study aimed to analyze the morphological changes in the foveal avascular zone (FAZ) after panretinal photocoagulation (PRP) in patients with diabetic retinopathy, with a particular focus on the presence or absence of c...

  • Article
  • Open Access
3 Citations
1,797 Views
10 Pages

Optical Coherence Tomography Angiography Changes in Macular Area in Patients with Proliferative Diabetic Retinopathy Treated with Panretinal Photocoagulation

  • Irini Chatziralli,
  • Eleni Dimitriou,
  • Chrysa Agapitou,
  • Dimitrios Kazantzis,
  • Petros Kapsis,
  • Nick Morogiannis,
  • Stylianos Kandarakis,
  • George Theodossiadis and
  • Panagiotis Theodossiadis

26 November 2023

Background: The purpose of this study was to investigate the changes in macular microvasculature using optical coherence tomography angiography (OCTA) in association with functional changes in patients with proliferative diabetic retinopathy (PDR) tr...

  • Article
  • Open Access
5 Citations
3,068 Views
10 Pages

Vision-Related Quality of Life and Treatment Satisfaction Following Panretinal Photocoagulation in Diabetic Retinopathy—A Panel Study

  • Jelena B. Vasilijević,
  • Igor M. Kovačević,
  • Zoran M. Bukumirić,
  • Gorica D. Marić,
  • Nikola A. Slijepčević and
  • Tatjana D. Pekmezović

28 November 2022

Background and Objectives: The aim of the study was to evaluate vision-related quality of life (VR-QOL) and treatment satisfaction (TS) in patients with diabetic retinopathy treated with panretinal photocoagulation (PRP). Material and Methods: The pa...

  • Article
  • Open Access
4 Citations
2,998 Views
10 Pages

23 November 2020

Objective: To investigate the effects of intravitreal bevacizumab (IVB) injection before PRP on the prevention of macular edema (ME) in patients with PDR. Methods: This retrospective observational study included patients diagnosed with PDR treated by...

  • Article
  • Open Access
10 Citations
3,266 Views
9 Pages

29 September 2021

Background: This study compares the change of retinal vessel density (VD) after pan-retinal photocoagulation (PRP) and intravitreal conbercept (IVC) treatment in proliferative diabetic retinopathy (PDR) eyes with optical coherence tomography angiogra...

  • Case Report
  • Open Access
12 Citations
1 Views
2 Pages

Retinal Vasculitis in Systemic Lupus Erythematosus: An Indication of Active Disease

  • Umi Kalthum Md Noh,
  • Aida Zairani A. Zahidin and
  • Then Kong Yong

A 26-year-old woman with a recent flare-up of systemic lupus erythematosus presented with peripheral retinal hemorrhages at a routine check-up. She is on a tapering dose of immunosuppressive agents. Her visual acuity was good. Fluorescein angiogram r...

  • Review
  • Open Access
2,608 Views
25 Pages

Retinal Laser Therapy Mechanisms, Innovations, and Clinical Applications

  • Xinyi Xie,
  • Luqman Munir and
  • Yannis Mantas Paulus

22 October 2025

Retinal laser therapy has been a mainstay for treating proliferative diabetic retinopathy, retinal vascular disease, and retinal breaks since 1961. However, conventional millisecond photocoagulation can cause permanent scarring and procedure discomfo...

  • Article
  • Open Access
13 Citations
3,850 Views
10 Pages

Low Luminance Visual Acuity and Low Luminance Deficit in Proliferative Diabetic Retinopathy

  • Eleni Karatsai,
  • Piyali Sen,
  • Sarega Gurudas and
  • Sobha Sivaprasad

19 January 2021

This study aimed to determine the relation of best corrected visual acuity (BCVA) and low luminance visual acuity (LLVA) in proliferative diabetic retinopathy (PDR) following treatment with either aflibercept or pan-retinal photocoagulation (PRP). Th...

  • Article
  • Open Access
9 Citations
3,694 Views
13 Pages

Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular Ischemia

  • Wei-Shan Tsai,
  • Sridevi Thottarath,
  • Sarega Gurudas,
  • Piyali Sen,
  • Elizabeth Pearce,
  • Andrea Giani,
  • Victor Chong,
  • Chui Ming Gemmy Cheung and
  • Sobha Sivaprasad

The thresholds of macular microvasculature parameters associated with mild visual impairment in diabetic macular ischemia (DMI) patients are unclear. Therefore, this prospective observational study is aimed at demonstrating the optical coherence tomo...

  • Case Report
  • Open Access
3 Citations
3,282 Views
8 Pages

16 October 2022

Purpose: To review the clinical features, diagnosis, and treatment of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) and to report a case with the use of ultra-widefield fluorescein angiography (UWFA) for confirming the precise...

  • Article
  • Open Access
3 Citations
2,298 Views
13 Pages

12 September 2023

Short-pulse laser is popular for its advantages like less pain. However, its effectiveness is still debated. The aim of this study was to compare fundus autofluorescence (FAF) luminosity changes of laser photocoagulation scars between the conventiona...

  • Review
  • Open Access
73 Citations
10,907 Views
19 Pages

Updates on the Current Treatments for Diabetic Retinopathy and Possibility of Future Oral Therapy

  • Yohei Tomita,
  • Deokho Lee,
  • Kazuo Tsubota,
  • Kazuno Negishi and
  • Toshihide Kurihara

12 October 2021

Diabetic retinopathy (DR) is a complication of diabetes and one of the leading causes of vision loss worldwide. Despite extensive efforts to reduce visual impairment, the prevalence of DR is still increasing. The initial pathophysiology of DR include...

  • Article
  • Open Access
20 Citations
2,711 Views
13 Pages

Efficacy and Safety of Intravitreal Fluocinolone Acetonide Implant for Chronic Diabetic Macular Edema Previously Treated in Real-Life Practice: The REALFAc Study

  • Thibaud Mathis,
  • Maxence Papegaey,
  • Cécile Ricard,
  • Amina Rezkallah,
  • Frédéric Matonti,
  • Aditya Sudhalkar,
  • Cristina Vartin,
  • Corinne Dot and
  • Laurent Kodjikian

Diabetic macular edema (DME) is the main cause of visual impairment in diabetic patients and a chronic disease requiring long-term treatments. The fluocinolone acetonide (FAc) implant has recently been approved to treat DME in patients considered ins...

  • Review
  • Open Access
29 Citations
13,644 Views
14 Pages

A Review of Neovascular Glaucoma: Etiology, Pathogenesis, Diagnosis, and Treatment

  • Danielė Urbonavičiūtė,
  • Dovilė Buteikienė and
  • Ingrida Janulevičienė

18 December 2022

Neovascular glaucoma (NVG) is a rare, aggressive, blinding secondary glaucoma, which is characterized by neovascularization of the anterior segment of the eye and leading to elevation of the intraocular pressure (IOP). The main etiological factor is...

  • Article
  • Open Access
8 Citations
2,924 Views
15 Pages

Epidemiology of Treated Diabetes Ocular Complications in France 2008–2018—The LANDSCAPE French Nationwide Study

  • Catherine Creuzot-Garcher,
  • Pascale Massin,
  • Mayer Srour,
  • Florian Baudin,
  • Corinne Dot,
  • Sylvia Nghiem-Buffet,
  • Jean-Francois Girmens,
  • Cedric Collin,
  • Anne Ponthieux and
  • Cecile Delcourt

Aim: LANDSCAPE aimed to estimate the annual incidence and prevalence of treated diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) between 2008 and 2018. Methods: This French nationwide observational study used data from the Fr...

  • Review
  • Open Access
55 Citations
10,171 Views
15 Pages

27 April 2023

Diabetic retinopathy (DR) is a microvascular disease caused by poorly controlled blood glucose, and it is a leading cause of vision loss in people with diabetes. In this review we discuss the current management of DR with particular focus on the use...

  • Systematic Review
  • Open Access
330 Views
10 Pages

Laser Speckle Flowgraphy (LSFG) in Age-Related Macular Degeneration and Diabetic Retinopathy: A Systematic Review of Recent Literature

  • Carlo Bellucci,
  • Medea Virgili,
  • Alessandra Romano,
  • Salvatore Antonio Tedesco and
  • Paolo Mora

17 December 2025

Background: Laser Speckle Flowgraphy (LSFG) is a non-invasive imaging technology that quantitatively evaluates retinal and choroidal blood flow by analyzing speckle patterns generated by laser light scattering. This systematic review summarizes the a...

  • Article
  • Open Access
704 Views
15 Pages

Intravitreal Aflibercept for the Treatment of Diabetic Retinopathy Among Patients Who Completed PANORAMA: 1-Year Outcomes from the VOYAGE Extension Study

  • Avery W. Zhou,
  • Gail M. Teagle,
  • Liisa M. Baumann,
  • Jessica A. Cao,
  • Andres Emanuelli,
  • Allen Y. Hu,
  • Adam S. Berger,
  • James C. Major,
  • Seong Y. Lee and
  • Charles C. Wykoff
  • + 16 authors

14 November 2025

Background/Objectives: Evaluate outcomes and treatment patterns with 2 mg intravitreal aflibercept injection among patients who completed the phase 3 PANORAMA trial and enrolled in the VOYAGE (ClinicalTrials.gov identifier, NCT04708145; 12 January 20...

  • Article
  • Open Access
3 Citations
1,918 Views
11 Pages

20 July 2024

Background: The goal of the study was to analyze variations in central, perifoveal, and peripheral retinal thickness (RT) and choroidal thickness (CT) in patients with diabetic macular edema (DME) measured with ultra-wide-field optical coherence tomo...

  • Review
  • Open Access
17 Citations
5,722 Views
23 Pages

Beyond VEGF: Angiopoietin–Tie Signaling Pathway in Diabetic Retinopathy

  • Genesis Chen-Li,
  • Rebeca Martinez-Archer,
  • Andres Coghi,
  • José A. Roca,
  • Francisco J. Rodriguez,
  • Luis Acaba-Berrocal,
  • María H. Berrocal and
  • Lihteh Wu

9 May 2024

Complications from diabetic retinopathy such as diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) constitute leading causes of preventable vision loss in working-age patients. Since vascular endothelial growth factor (VEGF) pl...

  • Review
  • Open Access
45 Citations
5,053 Views
19 Pages

Background: Diabetic retinopathy (DR) is the leading cause of blindness in the working-age population. The purpose of this review is to gather the existing literature regarding the use of the approved anti-vascular endothelial growth (anti-VEGF) agen...

  • Article
  • Open Access
1 Citations
2,308 Views
15 Pages

31 May 2024

Purpose: The purpose of this study is to investigate outcomes of visual acuity (VA) and intraocular pressure (IOP) in proliferative diabetic retinopathy (PDR)-associated neovascular glaucoma (NVG) in Japanese patients treated with surgical therapies...

  • Article
  • Open Access
2 Citations
1,225 Views
10 Pages

Screening Blood and Vitreous for Biomarkers Associated with Proliferative Diabetic Retinopathy

  • Stephen Richard,
  • Rawan Kharouba,
  • Jawad Abu-dbai,
  • Oksana Gagarin,
  • Assaf Kratz,
  • Basel Obied,
  • Alon Zahavi and
  • Nitza Goldenberg-Cohen

Background/Objectives: Uncontrolled or long-standing diabetes can lead to proliferative diabetic retinopathy (PDR), a condition that significantly impairs vision. A subset of patients does not respond adequately to conventional therapies, such as int...