Novel 2-amino bis(2-phosphonoacetic) acids were prepared by microwave irradiation of a mixture of amine, glyoxylic acid and phosphorous acid. The reaction takes place with various amines including primary and secondary amines and polyamines, but this...
The specific synthesis of N-alkylated pyridone has attracted considerable attention due to the presence of these units in a wide range of components, both in natural products and in many active pharmaceuticals. Generally, the synthesis of N-alkyl-2-p...
6-Hydroxy-2-oxo-2H-chromene-4-carbaldehyde (2), 6-chloro-2-oxo-2H-chromene-4-carbaldehyde (3) and 6-hydrazinyl-4-methyl-2H-chromen-2-one (5) were prepared as single-pharmacophore motif key intermediates. Compounds 2, 3 and 5 were incorporated in a s...
Nanoparticle-catalysed microwave-aided multicomponent reactions (MCRs) have been demonstrated to be competent and environmentally benign tools for the quick synthesis of a wide spectrum of fused heterocyclic systems. The distinctive physicochemical p...
A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS). These will pro...
The combination of multicomponent reactions with post-transformation processes is a powerful strategy for the rapid synthesis of structurally complex polyheterocycles. Herein, we describe the preparation of the novel compound 2-benzyl-6-(3-((7-chloro...
Isocyanides constitute a valuable class of organic compounds widely employed in multicomponent reactions (MCRs), heterocycle synthesis, and drug discovery. However, their broader application is limited by low commercial availability and hazardous cla...