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Correction published on 9 February 2015, see Molecules 2015, 20(2), 2835-2836.
Open AccessArticle

Microwave-Assisted Synthesis of Novel 2H-Chromene Derivatives Bearing Phenylthiazolidinones and Their Biological Activity Assessment

1
Chemistry Department, Faculty of Science, Aswan University, Aswan 81528, Egypt
2
Chemistry Department, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Taif 21974, Saudi Arabia
3
Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt
4
Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt
*
Author to whom correspondence should be addressed.
Molecules 2014, 19(12), 19648-19664; https://doi.org/10.3390/molecules191219648
Received: 29 September 2014 / Revised: 17 November 2014 / Accepted: 18 November 2014 / Published: 26 November 2014
(This article belongs to the Section Organic Chemistry)
6-Hydroxy-2-oxo-2H-chromene-4-carbaldehyde (2), 6-chloro-2-oxo-2H-chromene-4-carbaldehyde (3) and 6-hydrazinyl-4-methyl-2H-chromen-2-one (5) were prepared as single-pharmacophore motif key intermediates. Compounds 2, 3 and 5 were incorporated in a series of multicomponent reactions (MCRs), under microwave assistance as well as conventional chemical synthesis processes, to afford a series of three and/or four-pharmacophoric-motif conjugates 8a,b, 11, 13, 16, 17, 19 and 20 in good yields. The newly synthesized compounds were characterized by IR, NMR, 13C-NMR, MS and elemental analyses. Finally the synthesized compounds have been screened for their biological activity whereupon they exhibited remarkable antimicrobial activity on different classes of bacteria and the fungus. View Full-Text
Keywords: multicomponent reactions (MCRs); green synthesis; microwave irradiation; 2-H-chromene; thiazolidenone; biological activity multicomponent reactions (MCRs); green synthesis; microwave irradiation; 2-H-chromene; thiazolidenone; biological activity
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MDPI and ACS Style

El Azab, I.H.; Youssef, M.M.; Amin, M.A. Microwave-Assisted Synthesis of Novel 2H-Chromene Derivatives Bearing Phenylthiazolidinones and Their Biological Activity Assessment. Molecules 2014, 19, 19648-19664.

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