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11 Results Found

  • Article
  • Open Access
12 Citations
4,326 Views
13 Pages

Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against Candida Yeast by Inhibition of Lanosterol 14-Alpha Demethylase

  • Victor Marin,
  • Andres Iturra,
  • Andres Opazo,
  • Bernd Schmidt,
  • Matthias Heydenreich,
  • Leandro Ortiz,
  • Verónica A. Jiménez and
  • Cristian Paz

24 July 2020

Candida species cause an opportunistic yeast infection called Candidiasis, which is responsible for more than 50,000 deaths every year around the world. Effective treatments against candidiasis caused by non-albicans Candida species such as C. glabra...

  • Article
  • Open Access
16 Citations
6,491 Views
12 Pages

Human Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3′-Disulfate

  • Leonid Kaluzhskiy,
  • Pavel Ershov,
  • Evgeniy Yablokov,
  • Tatsiana Shkel,
  • Irina Grabovec,
  • Yuri Mezentsev,
  • Oksana Gnedenko,
  • Sergey Usanov,
  • Polina Shabunya and
  • Alexis Ivanov
  • + 6 authors

13 April 2021

Widespread pathologies such as atherosclerosis, metabolic syndrome and cancer are associated with dysregulation of sterol biosynthesis and metabolism. Cholesterol modulates the signaling pathways of neoplastic transformation and tumor progression. La...

  • Article
  • Open Access
7 Citations
6,171 Views
16 Pages

16 March 2024

Empirically, in Indonesia, the leaves of Cassia alata L. (candle bush or ketepeng cina) have been used as a topical antifungal agent. Malassezia furfur is a natural microorganism found in the human body. It is among the factors contributing to condit...

  • Article
  • Open Access
3 Citations
2,892 Views
19 Pages

Molecular Cloning, Heterologous Expression, Purification, and Evaluation of Protein–Ligand Interactions of CYP51 of Candida krusei Azole-Resistant Fungal Strain

  • Tatsiana V. Tsybruk,
  • Leonid A. Kaluzhskiy,
  • Yuri V. Mezentsev,
  • Tatyana N. Makarieva,
  • Kseniya M. Tabakmaher,
  • Natalia V. Ivanchina,
  • Pavel S. Dmitrenok,
  • Alexander V. Baranovsky,
  • Andrei A. Gilep and
  • Alexis S. Ivanov

Due to the increasing prevalence of fungal diseases caused by fungi of the genus Candida and the development of pathogen resistance to available drugs, the need to find new effective antifungal agents has increased. Azole antifungals, which are inhib...

  • Article
  • Open Access
8 Citations
3,013 Views
16 Pages

Chemical Characterization and Leishmanicidal Activity In Vitro and In Silico of Natural Products Obtained from Leaves of Vernonanthura brasiliana (L.) H. Rob (Asteraceae)

  • Yuri Nascimento Fróes,
  • João Guilherme Nantes Araújo,
  • Joyce Resende dos Santos Gonçalves,
  • Milena de Jesus Marinho Garcia de Oliveira,
  • Gustavo Oliveira Everton,
  • Victor Elias Mouchrek Filho,
  • Maria Raimunda Chagas Silva,
  • Luís Douglas Miranda Silva,
  • Lucilene Amorim Silva and
  • Joicy Cortez de Sá Sousa
  • + 7 authors

16 February 2023

Vernonanthura brasiliana (L.) H. Rob is a medicinal plant used for the treatment of several infections. This study aimed to evaluate the antileishmanial activity of V. brasiliana leaves using in vitro and in silico approaches. The chemical...

  • Article
  • Open Access
3 Citations
1,149 Views
12 Pages

Exploring the Anti-Chagas Activity of Zanthoxylum chiloperone’s Seedlings Through Metabolomics and Protein–Ligand Docking

  • Ninfa Vera de Bilbao,
  • Ryland T. Giebelhaus,
  • Ryan P. Dias,
  • Maria Elena Ferreira,
  • Miguel Martínez,
  • Lorea Velasco-Carneros,
  • Seo Lin Nam,
  • A. Paulina de la Mata,
  • Jean-Didier Maréchal and
  • Gerardo Cebrián-Torrejón
  • + 9 authors

18 March 2025

This publication reports the controlled cultivation of Zanthoxylum chiloperone var. angustifolium Engl. (Rutaceae) in several growth substrates under controlled greenhouse conditions. This plant is well-known for its anti-Chagas (trypanocidal) activi...

  • Article
  • Open Access
4 Citations
2,706 Views
19 Pages

Microwave-Assisted Synthesis of Aminophosphonic Derivatives and Their Antifungal Evaluation against Lomentospora prolificans

  • Zuleyma Martínez-Campos,
  • Mariana Elizondo-Zertuche,
  • Emanuel Hernández-Núñez,
  • Eugenio Hernández-Fernández,
  • Efrén Robledo-Leal and
  • Susana T. López-Cortina

Lomentospora prolificans is a pathogenic and multidrug-resistant fungus that can infect both immunocompetent and immunocompromised patients, with mortality rates up to 87%. The World Health Organization (WHO) included this fungal species in its first...

  • Article
  • Open Access
4 Citations
2,912 Views
12 Pages

Drimane Sesquiterpene Aldehydes Control Candida Yeast Isolated from Candidemia in Chilean Patients

  • Víctor Marín,
  • Bryan Bart,
  • Nicole Cortez,
  • Verónica A. Jiménez,
  • Víctor Silva,
  • Oscar Leyton,
  • Jaime R. Cabrera-Pardo,
  • Bernd Schmidt,
  • Matthias Heydenreich and
  • Cristian Paz
  • + 1 author

4 October 2022

Drimys winteri J.R. (Winteraceae) produce drimane sesquiterpenoids with activity against Candida yeast. In this work, drimenol, polygodial (1), isotadeonal (2), and a new drimane α,β-unsaturated 1,4-dialdehyde, named winterdial (4), were p...

  • Article
  • Open Access
16 Citations
3,697 Views
17 Pages

Triazole Derivatives Target 14α–Demethylase (LDM) Enzyme in Candida albicans Causing Ergosterol Biosynthesis Inhibition

  • Irfan A. Rather,
  • Jamal S. M. Sabir,
  • Amer H. Asseri,
  • Mohmmad Younus Wani and
  • Aijaz Ahmad

29 June 2022

Candida albicans is the most dominant and prevalent cause of fungal infections in humans. Azoles are considered as first-line drugs for the treatment of these infections. However, their prolonged and insistent use has led to multidrug resistance and...

  • Article
  • Open Access
20 Citations
4,023 Views
13 Pages

1 January 2023

The antifungal effect of metabolites produced by a new strain of Lactiplantibacillus (Lpb.) plantarum LPP703, isolated from naturally fermented yak yogurt, was investigated. The results showed that Lpb. plantarum LPP703 significantly inhibited four f...

  • Article
  • Open Access
4 Citations
2,595 Views
29 Pages

Green Fabrication of Silver Nanoparticles, Statistical Process Optimization, Characterization, and Molecular Docking Analysis of Their Antimicrobial Activities onto Cotton Fabrics

  • Nada S. Shweqa,
  • Noura El-Ahmady El-Naggar,
  • Hala M. Abdelmigid,
  • Amal A. Alyamani,
  • Naglaa Elshafey,
  • Hadeel El-Shall,
  • Yasmin M. Heikal and
  • Hoda M. Soliman

21 November 2024

Nanotechnological methods for creating multifunctional fabrics are attracting global interest. The incorporation of nanoparticles in the field of textiles enables the creation of multifunctional textiles exhibiting UV irradiation protection, antimicr...