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6 Results Found

  • Article
  • Open Access
1,375 Views
20 Pages

Multimodal Behavior Scoring Quantifies Depression-like Severity Across Chronic Stress Models and Identifies Stress-Resilient Mice

  • Yue Tu,
  • Qinghui Fu,
  • Canghao Sun,
  • Jing Deng and ,
  • Haoning Qin,
  • Xianlin Zeng,
  • Yuchuan Wang,
  • Shulan Qiu and
  • Weixiong Zhang
  • + 4 authors+ 0 author

Rodent models, especially chronic stress paradigms, are essential in depression research, yet existing behavioral assessments often struggle to capture pathophysiological heterogeneity. We developed the Multimodal Behavior Scoring (MBS) algorithm, wh...

  • Article
  • Open Access
2 Citations
2,873 Views
21 Pages

Serum Metabolites as Potential Markers and Predictors of Depression-like Behavior and Effective Fluoxetine Treatment in Chronically Socially Isolated Rats

  • Dragana Filipović,
  • Julica Inderhees,
  • Alexandra Korda,
  • Predrag Tadić and ,
  • Markus Schwaninger,
  • Dragoš Inta and
  • Stefan Borgwardt
  • + 2 authors+ 0 author

Metabolic perturbation has been associated with depression. An untargeted metabolomics approach using liquid chromatography-high resolution mass spectrometry was employed to detect and measure the rat serum metabolic changes following chronic social...

  • Article
  • Open Access
200 Views
24 Pages

The Construction and Validation of a Machine Learning Model for Major Depressive Disorder Based on Astrocytes and Mitochondrial Dynamics

  • Shi Lin,
  • Gaoyuan Wang,
  • Xiaoqin Shao,
  • Yinghui Mo and ,
  • Yating Song,
  • Zuyi Lu,
  • Jiangli Zhou,
  • Zhiqing Lu,
  • Quan Wen and
  • Qian Wang
  • + 6 authors+ 1 author

Background: Astrocytes play an important role in depression. However, their specific mechanisms, especially their subcellular mechanisms, remain unclear. Objective: We aimed to identify key genes associated with mitochondrial dynamics and astrocytes...

(This article belongs to the Section Molecular Medicine)
  • Review
  • Open Access
15 Citations
4,882 Views
12 Pages

Adherence and the Diabetic Foot: High Tech Meets High Touch?

  • Hadia Srass,
  • J. Karim Ead and
  • David G. Armstrong

3 August 2023

Diabetic foot ulcers, which are a common complication of diabetes, can have a negative impact on a person’s physical and mental health, including an increased risk of depression. Patients suffering from depression are less likely to keep up wit...

(This article belongs to the Special Issue Saving Limbs and Lives-Sensing and Monitoring Technologies for the Diabetic Foot)
  • Article
  • Open Access
25 Citations
4,839 Views
16 Pages

Research to assess the burden of non-communicable diseases (NCDs) among the transgender population needs to be prioritized given the high prevalence of chronic conditions and associated risk factors in this group. Previous cross-sectional studies uti...

(This article belongs to the Special Issue Sexual and Gender Diversity in Healthcare Provision)
  • Systematic Review
  • Open Access
367 Views
28 Pages

Armed conflict is a well-established risk factor for children’s mental health, yet young children remain underrepresented in research on mental health among children affected by conflict in the Gaza Strip. This systematic review synthesized evi...

(This article belongs to the Topic Behavioral Addictions and Risk-Taking in the Digital Age: Gambling, Sports Betting, and Emerging Challenges)