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Article

2 Citations

4,198 Views

13 Pages

Tc-99m TRODAT-1 SPECT is a Potential Biomarker for Restless Leg Syndrome in Patients with End-Stage Renal Disease

Yi-Chou Hou,
Yu-Ming Fan,
Ya-Ching Huang,
Ruei-Ming Chen,
Cheng-Hsu Wang,
Yi-Te Lin,
Tzung-Hai Yen,
Kuo-Cheng Lu and
Yuh-Feng Lin

J. Clin. Med.2020, 9(3), 889;https://doi.org/10.3390/jcm9030889

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24 March 2020

Rationales: Restless leg syndrome (RLS) is a common complication in patients with end-stage renal disease (ESRD). However, there is a lack of biomarkers linking uremic RLS to dopaminergic neurons. Previous studies demonstrated that Tc-99m TRODAT-1 SP...

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Article

1 Citations

2,783 Views

10 Pages

The Titrated Mannitol Improved Central [^99mTc] Tc TRODAT-1 Uptake in an Animal Model—A Clinically Feasible Application

Kang-Wei Chang,
Po-Ling Chang,
Chi-Jung Tsai,
Ya-Ju Tsai,
Ping-Hsiu Wu,
Hsin-Lun Lee,
Yu-Hua Lai,
Ching-Yee Oliver Wong and
Wen-Sheng Huang

Int. J. Mol. Sci.2023, 24(4), 3773;https://doi.org/10.3390/ijms24043773

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14 February 2023

[99mTc]Tc TRODAT-1 is a widely used single photon emission tomography (SPECT) radiopharmaceutical in Asian practice for early detection of central dopaminergic disorders. However, its imaging quality remains sub-optimal. To overcome this problem, man...

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Article

34 Citations

5,224 Views

12 Pages

Feasible Classified Models for Parkinson Disease from ^99mTc-TRODAT-1 SPECT Imaging

Shih-Yen Hsu,
Hsin-Chieh Lin,
Tai-Been Chen,
Wei-Chang Du,
Yun-Hsuan Hsu,
Yi-Chen Wu,
Po-Wei Tu,
Yung-Hui Huang and
Huei-Yung Chen

Sensors2019, 19(7), 1740;https://doi.org/10.3390/s19071740

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11 April 2019

The neuroimaging techniques such as dopaminergic imaging using Single Photon Emission Computed Tomography (SPECT) with 99mTc-TRODAT-1 have been employed to detect the stages of Parkinson’s disease (PD). In this retrospective study, a total of 2...

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Article

2 Citations

3,668 Views

10 Pages

Low-Parameter Small Convolutional Neural Network Applied to Functional Medical Imaging of Tc-99m Trodat-1 Brain Single-Photon Emission Computed Tomography for Parkinson’s Disease

Yu-Chieh Chang,
Te-Chun Hsieh,
Jui-Cheng Chen,
Kuan-Pin Wang,
Zong-Kai Hsu,
Pak-Ki Chan and
Chia-Hung Kao

J. Pers. Med.2022, 12(1), 1;https://doi.org/10.3390/jpm12010001

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21 December 2021

Parkinson’s disease (PD), a progressive disease that affects movement, is related to dopaminergic neuron degeneration. Tc-99m Trodat-1 brain (TRODAT) single-photon emission computed tomography (SPECT) aids the functional imaging of dopamine tra...

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Article

2 Citations

2,883 Views

15 Pages

Multi-Modal Synergistic 99mTc-TRODAT-1 SPECT and MRI for Evaluation of the Efficacy of Hyperbaric Oxygen Therapy in CO-Induced Delayed Parkinsonian and Non-Parkinsonian Syndromes

Skye Hsin-Hsien Yeh,
Chuang-Hsin Chiu,
Hung-Wen Kao,
Ching-Po Lin,
Yu-Hus Lai and
Wen-Sheng Huang

Antioxidants2022, 11(11), 2289;https://doi.org/10.3390/antiox11112289

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18 November 2022

Background: Delayed neuropsychiatric syndrome (DNS) is characterized by motor dysfunction after acute carbon monoxide (CO) poisoning. We examined the relationship between dopamine transporter (DAT) loss using kit-based Tc-99m-TRODAT-1 (DAT single-pho...

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Communication

2 Citations

2,390 Views

7 Pages

Does TRODAT-1 SPECT Uptake Correlate with Cerebrospinal Fluid α-Synuclein Levels in Mid-Stage Parkinson’s Disease?

Artur M. Coutinho,
Maria Gabriela Ghilardi,
Ana Carolina P. Campos,
Elba Etchebehere,
Fernanda C. Fonoff,
Rubens G. Cury,
Rosana L. Pagano,
Raquel C. R. Martinez and
Erich T. Fonoff

Biomedicines2023, 11(2), 296;https://doi.org/10.3390/biomedicines11020296

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20 January 2023

Background: Parkinson’s disease (PD) is characterized by a progressive loss of nigrostriatal dopaminergic neurons with impaired motor and non-motor symptoms. It has been suggested that motor asymmetry could be caused due to an imbalance in dopa...

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Article

2 Citations

1,976 Views

10 Pages

Real-World Testing of a Machine Learning–Derived Visual Scale for Tc99m TRODAT-1 for Diagnosing Lewy Body Disease: Comparison with a Traditional Approach Using Semiquantification

Pai-Yi Chiu,
Po-Nien Hou,
Guang-Uei Hung,
Te-Chun Hsieh,
Pak-Ki Chan and
Chia-Hung Kao

J. Pers. Med.2022, 12(9), 1369;https://doi.org/10.3390/jpm12091369

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25 August 2022

Objectives: Abnormal dopamine transporter (DAT) uptake is an important biomarker for diagnosing Lewy body disease (LBD), including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). We evaluated a machine learning-derived visual scal...

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Article

27 Citations

4,183 Views

17 Pages

Classification of the Multiple Stages of Parkinson’s Disease by a Deep Convolution Neural Network Based on ^99mTc-TRODAT-1 SPECT Images

Shih-Yen Hsu,
Li-Ren Yeh,
Tai-Been Chen,
Wei-Chang Du,
Yung-Hui Huang,
Wen-Hung Twan,
Ming-Chia Lin,
Yun-Hsuan Hsu,
Yi-Chen Wu and
Huei-Yung Chen

Molecules2020, 25(20), 4792;https://doi.org/10.3390/molecules25204792

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19 October 2020

Single photon emission computed tomography (SPECT) has been employed to detect Parkinson’s disease (PD). However, analysis of the SPECT PD images was mostly based on the region of interest (ROI) approach. Due to limited size of the ROI, especia...

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Article

21 Citations

4,685 Views

8 Pages

Comparative Study of Two Oxidizing Agents, Chloramine T and Iodo-Gen^®, for the Radiolabeling of β-CIT with Iodine-131: Relevance for Parkinson’s Disease

Ana Claudia R. Durante,
Danielle V. Sobral,
Ana Claudia C. Miranda,
Érika V. de Almeida,
Leonardo L. Fuscaldi,
Marycel R. F. F. de Barboza and
Luciana Malavolta

Pharmaceuticals2019, 12(1), 25;https://doi.org/10.3390/ph12010025

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5 February 2019

Parkinson’s disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to alteration of the integrity of dopaminergic transporters (DATs). In recent years, some r...

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Review

8 Citations

5,008 Views

22 Pages

Neuroimaging Techniques in Differentiating Parkinson’s Disease from Drug-Induced Parkinsonism: A Comprehensive Review

Jamir Pitton Rissardo and
Ana Letícia Fornari Caprara

Clin. Pract.2023, 13(6), 1427-1448;https://doi.org/10.3390/clinpract13060128

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15 November 2023

Neuroimaging can provide significant benefits in evaluating patients with movement disorders associated with drugs. This literature review describes neuroimaging techniques performed to distinguish Parkinson’s disease from drug-induced parkinso...

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Article

5 Citations

2,822 Views

21 Pages

A Shape Approximation for Medical Imaging Data

Shih-Feng Huang,
Yung-Hsuan Wen,
Chi-Hsiang Chu and
Chien-Chin Hsu

Sensors2020, 20(20), 5879;https://doi.org/10.3390/s20205879

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17 October 2020

This study proposes a shape approximation approach to portray the regions of interest (ROI) from medical imaging data. An effective algorithm to achieve an optimal approximation is proposed based on the framework of Particle Swarm Optimization. The c...

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Article

5 Citations

5,797 Views

12 Pages

Dopaminergic Degeneration and Small Vessel Disease in Patients with Normal Pressure Hydrocephalus Who Underwent Shunt Surgery

Tze-Wei Chang,
Pao-Hui Tseng,
Yi-Cheng Wang,
Guo-Fang Tseng,
Tsung-Lang Chiu,
Shinn-Zong Lin and
Sheng-Tzung Tsai

J. Clin. Med.2020, 9(4), 1084;https://doi.org/10.3390/jcm9041084

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11 April 2020

The diagnosis of idiopathic normal pressure hydrocephalus (iNPH) and the outcome of lumboperitoneal shunt treatment remains to be systematically explored. Here, we aim to evaluate whether the severity of dopaminergic degeneration and white matter sma...

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12 Results Found

Tc-99m TRODAT-1 SPECT is a Potential Biomarker for Restless Leg Syndrome in Patients with End-Stage Renal Disease

The Titrated Mannitol Improved Central [99mTc] Tc TRODAT-1 Uptake in an Animal Model—A Clinically Feasible Application

Feasible Classified Models for Parkinson Disease from 99mTc-TRODAT-1 SPECT Imaging

Low-Parameter Small Convolutional Neural Network Applied to Functional Medical Imaging of Tc-99m Trodat-1 Brain Single-Photon Emission Computed Tomography for Parkinson’s Disease

Multi-Modal Synergistic 99mTc-TRODAT-1 SPECT and MRI for Evaluation of the Efficacy of Hyperbaric Oxygen Therapy in CO-Induced Delayed Parkinsonian and Non-Parkinsonian Syndromes

Does TRODAT-1 SPECT Uptake Correlate with Cerebrospinal Fluid α-Synuclein Levels in Mid-Stage Parkinson’s Disease?

Real-World Testing of a Machine Learning–Derived Visual Scale for Tc99m TRODAT-1 for Diagnosing Lewy Body Disease: Comparison with a Traditional Approach Using Semiquantification

Classification of the Multiple Stages of Parkinson’s Disease by a Deep Convolution Neural Network Based on 99mTc-TRODAT-1 SPECT Images

Comparative Study of Two Oxidizing Agents, Chloramine T and Iodo-Gen®, for the Radiolabeling of β-CIT with Iodine-131: Relevance for Parkinson’s Disease

Neuroimaging Techniques in Differentiating Parkinson’s Disease from Drug-Induced Parkinsonism: A Comprehensive Review

A Shape Approximation for Medical Imaging Data

Dopaminergic Degeneration and Small Vessel Disease in Patients with Normal Pressure Hydrocephalus Who Underwent Shunt Surgery

The Titrated Mannitol Improved Central [^99mTc] Tc TRODAT-1 Uptake in an Animal Model—A Clinically Feasible Application

Feasible Classified Models for Parkinson Disease from ^99mTc-TRODAT-1 SPECT Imaging

Classification of the Multiple Stages of Parkinson’s Disease by a Deep Convolution Neural Network Based on ^99mTc-TRODAT-1 SPECT Images

Comparative Study of Two Oxidizing Agents, Chloramine T and Iodo-Gen^®, for the Radiolabeling of β-CIT with Iodine-131: Relevance for Parkinson’s Disease