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10 Results Found

  • Article
  • Open Access
29 Citations
7,570 Views
17 Pages

Mid-Frequency Hearing Loss Is Characteristic Clinical Feature of OTOA-Associated Hearing Loss

  • Kenjiro Sugiyama,
  • Hideaki Moteki,
  • Shin-ichiro Kitajiri,
  • Tomohiro Kitano and ,
  • Shin-ya Nishio,
  • Tomomi Yamaguchi,
  • Keiko Wakui,
  • Satoko Abe,
  • Akiko Ozaki and
  • Shin-ichi Usami
  • + 10 authors+ 5 authors

16 September 2019

The OTOA gene (Locus: DFNB22) is reported to be one of the causative genes for non-syndromic autosomal recessive hearing loss. The copy number variations (CNVs) identified in this gene are also known to cause hearing loss, but have not been identifie...

(This article belongs to the Special Issue Genetic Epidemiology of Deafness)
  • Case Report
  • Open Access
2 Citations
1,804 Views
11 Pages

Unveiling Secondary Mutations in Blended Phenotypes: Dual ERCC4 and OTOA Pathogenic Variants Through WES Analysis

  • Pinella Failla,
  • Lucia Saccuzzo,
  • Ornella Galesi,
  • Donatella Greco and ,
  • Vincenza Barresi,
  • Silvestra Amata,
  • Corrado Romano and
  • Marco Fichera
  • + 3 authors+ 0 author

16 December 2024

This study describes two siblings from consanguineous parents who exhibit intellectual disability, microcephaly, photosensitivity, bilateral sensorineural hearing loss, numerous freckles, and other clinical features that suggest a potential disruptio...

(This article belongs to the Collection Feature Papers in Molecular Genetics and Genomics)
  • Case Report
  • Open Access
3 Citations
4,278 Views
10 Pages

Compound Heterozygosity for OTOA Truncating Variant and Genomic Rearrangement Cause Autosomal Recessive Sensorineural Hearing Loss in an Italian Family

  • Rocco Pio Ortore,
  • Maria Pia Leone,
  • Orazio Palumbo,
  • Antonio Petracca and ,
  • Eleonora M. C. Trecca,
  • Aurelio D’Ecclesia,
  • Ciro Lucio Vigliaroli,
  • Lucia Micale,
  • Francesco Longo and
  • Marco Castori
  • + 6 authors+ 1 author

9 September 2021

Hearing loss (HL) affects 1–3 newborns per 1000 and, in industrialized countries, recognizes a genetic etiology in more than 80% of the congenital cases. Excluding GJB2 and GJB6, OTOA is one of the leading genes associated with autosomal recessive no...

(This article belongs to the Special Issue Genetics of Hearing Loss)
  • Article
  • Open Access
868 Views
24 Pages

Evaluation of the Biodegradability Potential of Antibacterial Poly(lactic acid)/Glycero-(9,10-trioxolane)-trialeate Films in Soil

  • Olga V. Alexeeva,
  • Yulia V. Tertyshnaya,
  • Sergey S. Kozlov,
  • Vyacheslav V. Podmasterev and ,
  • Valentina Siracusa,
  • Olga K. Karyagina,
  • Sergey M. Lomakin,
  • Tuyara V. Petrova,
  • Levon Yu. Martirosyan and
  • Alexey L. Iordanskii
  • + 6 authors+ 1 author

13 January 2026

Glycerol-(9,10-trioxolane) trioleate (OTOA) is a promising material that combines good plasticizing properties for PLA with profound antimicrobial activity, which makes it suitable for application in state-of-the-art biomedical and packaging material...

(This article belongs to the Special Issue Synthesis, Characterization and Environmental Assessment of Novel Polymeric Materials for Sustainable Applications)
  • Article
  • Open Access
9 Citations
3,710 Views
19 Pages

Effect of Glycero-(9,10-trioxolane)-trialeate on the Physicochemical Properties of Non-Woven Polylactic Acid Fiber Materials

  • Anatoliy Olkhov,
  • Olga Alexeeva,
  • Marina Konstantinova,
  • Vyacheslav Podmasterev and ,
  • Polina Tyubaeva,
  • Anna Borunova,
  • Valentina Siracusa and
  • Alex L. Iordanskii
  • + 3 authors+ 0 author

30 July 2021

Biocompatible glycero (9,10-trioxolane) trioleate (ozonide of oleic acid triglyceride, OTOA) was incorporated into polylactic acid (PLA) fibers by electrospinning and nonwoven PLA mats with 1%, 3% and 5% OTOA content. The morphological, mechanical, t...

  • Article
  • Open Access
4 Citations
1,964 Views
21 Pages

Characterization and Evaluation of Zero-Order Release System Comprising Glycero-(9,10-trioxolane)-trialeate and PLA: Opportunity for Packaging and Biomedicine Applications

  • Olga V. Alexeeva,
  • Marina L. Konstantinova,
  • Valentina Siracusa,
  • Vyacheslav V. Podmasterev and ,
  • Levon Yu. Martirosyan,
  • Olga K. Karyagina,
  • Sergey S. Kozlov,
  • Sergey M. Lomakin,
  • Ilya V. Tretyakov and
  • Alexey L. Iordanskii
  • + 6 authors+ 1 author

20 December 2024

Glycerol-(9,10-trioxolane) trioleate (OTOA) is a promising material that combines good plasticizing properties for PLA with profound antimicrobial activity, which makes it suitable for application in state-of-the-art biomedical and packaging material...

(This article belongs to the Section Polymer Applications)
  • Article
  • Open Access
7 Citations
2,589 Views
22 Pages

A Novel Approach for Glycero-(9,10-trioxolane)-Trialeate Incorporation into Poly(lactic acid)/Poly(ɛ-caprolactone) Blends for Biomedicine and Packaging

  • Olga V. Alexeeva,
  • Anatoliy A. Olkhov,
  • Marina L. Konstantinova,
  • Vyacheslav V. Podmasterev and ,
  • Tuyara V. Petrova,
  • Levon Yu. Martirosyan,
  • Olga K. Karyagina,
  • Sergey S. Kozlov,
  • Sergey M. Lomakin and
  • Alexey L. Iordanskii
  • + 7 authors+ 2 authors

30 December 2023

The product of ozonolysis, glycero-(9,10-trioxolane)-trioleate (ozonide of oleic acid triglyceride, [OTOA]), was incorporated into polylactic acid/polycaprolactone (PLA/PCL) blend films in the amount of 1, 5, 10, 20, 30 and 40% w/w. The morphological...

(This article belongs to the Topic Polymers from Renewable Resources, 2nd Volume)
  • Article
  • Open Access
9 Citations
2,753 Views
20 Pages

Improvement of the Structure and Physicochemical Properties of Polylactic Acid Films by Addition of Glycero-(9,10-trioxolane)-Trialeate

  • Olga Alexeeva,
  • Anatoliy Olkhov,
  • Marina Konstantinova,
  • Vyacheslav Podmasterev and ,
  • Ilya Tretyakov,
  • Tuyara Petrova,
  • Olga Koryagina,
  • Sergey Lomakin,
  • Valentina Siracusa and
  • Alexey L. Iordanskii
  • + 5 authors+ 0 author

25 August 2022

Glycero-(9,10-trioxolane)-trioleate (ozonide of oleic acid triglyceride, OTOA) was introduced into polylactic acid (PLA) films in amounts of 5, 10, 30, 50, and 70% w/w. The morphological, mechanical, thermal, and water absorption properties of PLA fi...

(This article belongs to the Topic Polymers from Renewable Resources)
  • Article
  • Open Access
30 Citations
8,493 Views
16 Pages

Lights and Shadows in the Genetics of Syndromic and Non-Syndromic Hearing Loss in the Italian Population

  • Anna Morgan,
  • Stefania Lenarduzzi,
  • Beatrice Spedicati,
  • Elisabetta Cattaruzzi and ,
  • Flora Maria Murru,
  • Giulia Pelliccione,
  • Daniela Mazzà,
  • Marcella Zollino,
  • Claudio Graziano and
  • Giorgia Girotto
  • + 8 authors+ 3 authors

22 October 2020

Hearing loss (HL), both syndromic (SHL) and non-syndromic (NSHL), is the most common sensory disorder, affecting ~460 million people worldwide. More than 50% of the congenital/childhood cases are attributable to genetic causes, highlighting the impor...

(This article belongs to the Special Issue Genetics of Hearing Impairment)
  • Article
  • Open Access
3 Citations
2,674 Views
14 Pages

Comparative Blood Transcriptome Analysis of Semi-Natural and Controlled Environment Populations of Yangtze Finless Porpoise

  • Wang Liu,
  • Denghua Yin,
  • Zhanwei Li,
  • Xiaoyan Zhu and ,
  • Sigang Zhang,
  • Peng Zhang,
  • Danqing Lin,
  • Zhong Hua,
  • Zhichen Cao and
  • Kai Liu
  • + 10 authors+ 5 authors

7 January 2024

The Yangtze finless porpoises (Neophocaena asiaeorientalis asiaeorientalis) living in different environments display significant differences in behavior and physiology. To compare and analyze gene expression differences between an ex situ population...

(This article belongs to the Section Aquatic Animals)