Estrogens play critical roles in embryonic development, gonadal sex differentiation, behavior, and reproduction in vertebrates and in several human cancers. Estrogens are synthesized from testosterone and androstenedione by the endoplasmic reticulum...
Oxidative reactions catalyzed by Cytochrome P450 enzymes (CYPs), which constitute the most relevant group of drug-metabolizing enzymes, are enabled by their redox partner Cytochrome P450 reductase (CPR). Both proteins are anchored to the membrane of...
Dehydroepiandrosterone (DHEA), a precursor of steroid sex hormones, is synthesized by steroid 17-alpha-hydroxylase/17,20-lyase (CYP17A1) with the participation of microsomal cytochrome b5 (CYB5A) and cytochrome P450 reductase (CPR), followed by sulfa...
Waste vegetable oil-based regenerants (WVO-Rs) are essential for sustainable asphalt pavements; however, their formulation optimization frameworks remain insufficient, and both the component synergy and the multi-component regeneration mechanism rema...
To validate a positive relationship between air temperature (T) and atmospheric substances (S/G, a ratio of diffuse solar radiation to global solar radiation) found at four typical stations on the Earth, and a further investigation was conducted. Bas...
Strain monitoring during the service life of a nuclear containment structure is an effective means to evaluate whether the structure is operating safely. Due to the failure of embedded strain sensors, surface-mounted strain sensors should be installe...