65 Results Found

Single-chain variable fragments (scFv) are antigen-recognizing variable fragments of antibodies (FV) where both subunits (VL and VH) are connected via an artificial linker. One particular scFv, iKM33, directed against blood coagulation factor VIII (F...

The continuous emergence of SARS-CoV-2 variants with enhanced transmissibility and immune escape capability underscores the urgent need for mutation-independent anti-viral strategies. SARS-CoV-2 non-structural protein 12 (NSP12), which encodes the RN...

This paper presents a novel Ripple Evolution Optimizer (REO) that incorporates adaptive and diversified movement—a population-based metaheuristic that turns a coastal-dynamics metaphor into principled search operators. REO augments a JADE-style...

Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1) plays a critical role in regulating the activity of Rho guanosine triphosphatases (GTPases). Phosphorylation of RhoGDI1 dynamically modulates the activation of Rho GTPases, influencing cell pr...

Recent trends indicate diminishing public engagement with formal electoral politics in many advanced liberal democracies, especially among the younger generations. However, evidence also suggests that there has been a simultaneous interest by many yo...

Calmodulin (CaM) is well known as an activator of calcium/calmodulin-dependent protein kinase II (CaMKII). Voltage-gated sodium channels (VGSCs) are basic signaling molecules in excitable cells and are crucial molecular targets for nervous system age...

Long non-coding RNAs (lncRNAs) are increasingly recognized as key regulators of gene expression and cellular signaling in cancer. Their functions are primarily mediated through interactions with specific protein partners that modulate chromatin struc...

Hyperactivation of Wnt signaling is crucial in tumor formation. Fully elucidating the molecular details of how the cancer-specific Wnt signaling pathway is activated or contributes to tumorigenesis will help in determining future treatment strategies...

In this paper, a mask region-based convolutional neural network (Mask R-CNN) is used to improve the performance of machine vision in the challenging task of detecting peduncles and fruits of green sweet peppers (Capsicum annuum L.) in greenhouses. On...

Background/Objectives: Honokiol (HK), a bioactive phenolic compound, exhibits significant anti-cancer properties. This study aimed to investigate the anti-cancer effects of HK in colorectal cancer (CRC) cells by focusing on its direct interaction wit...

Gripping, holding, and moving objects are among the main functional purposes of robots. Ever since automation first took hold in society, optimizing these functions has been of high priority, and a multitude of approaches has been taken to enable che...

Cryptocurrencies offer various benefits in terms of privacy protection and cross-border transactions, but they have also been used for illicit activities such as money laundering due to their anonymous nature and the difficulty of cross-border regula...

Regulation at the RNA level by RNA-binding proteins (RBPs) and microRNAs (miRNAs) is key to coordinating eukaryotic gene expression. In plants, the importance of miRNAs is highlighted by severe developmental defects in mutants impaired in miRNA bioge...

Four main unconformities (1–4) were recognized in the sedimentary record of the Cenozoic basins of the eastern External Betic Zone (SE, Spain). They are located at different stratigraphic levels, as follows: (1) Cretaceous-Paleogene boundary, e...

Background/Objectives: Atherosclerosis (AS)-related cardiovascular diseases are a major global health threat, with vascular smooth muscle cells (VSMCs) phenotypic switching, abnormal proliferation, and migration as key progression drivers. Nuclear re...