New Developments of Natural Killer (NK) Cells in Immunotherapy

Dear Colleagues,

Most of the first natural killer (NK) cell papers in the 1970s described a cytolytic effect on various tumor cell lines, so the idea of using NK cells in immunotherapy of cancer rapidly came up. However, success in the clinical settings was very limited. Four decades later, the therapeutic possibilities given by these cells have reached an unanticipated level of sophistication and diversity that goes in parallel with a steadily increasing knowledge about NK cell biology. Even if they are mistakenly less considered than chimeric antigen receptor (CAR)-T cells, NK cells have become a serious option for cancer treatment, although by far not all problems are resolved. The interest of the scientific community is highlighted by the increasing number of reviews about this topic. In the present Special Issue of Cells, experts in the field will describe the state-of-the-art in NK cell-based immunotherapy in 2020, based on their own expertise and on literature published in recent years.

Dr. Jacques Zimmer
Prof. Dr. Vladimir Jurisic
Guest Editors

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