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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antiviral Resistance Mutations

edited by

Ilaria Vicenti

and

Francesco Saladini

submission deadline 31 Aug 2025 | 11 articles | Viewed by 17378 | Submission Open

Keywords: antiviral resistance; virus evolution; viral genome mutation; drug-resistant phenotypes; immune escape

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Hepatitis E: Molecular Virology, Pathogenesis, and Treatment, 2nd Edition

edited by

Hiroaki Okamoto

submission deadline 31 Aug 2025 | 8 articles | Viewed by 10298 | Submission Open

Keywords: HEV; HEV life cycle; HEV genotypes; model systems; zoonosis; pathogenesis; HEV– host interations; antivirals

(This special issue belongs to the Section Human Virology and Viral Diseases)

Emerging and Reemerging Plant Viruses in a Changing World

edited by

Giuseppe Parrella

and

Raed Alkowni

submission deadline 31 Aug 2025 | 7 articles | Viewed by 9140 | Submission Open

Keywords: emerging and re-emerging viruses; virus spillover; climate change and global trade; mixed infections; plant– virus– vector relationships

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Aquatic Animal Viruses and Antiviral Immunity

edited by

Mark Polinski

submission deadline 31 Aug 2025 | 9 articles | Viewed by 8894 | Submission Open

Keywords: aquatic virus; aquatic animals; innate immunity; adaptive immunity; host– virus interactions; fish; aquaculture; biomedical research; aquatic animal stewardship

(This special issue belongs to the Section Animal Viruses)

Influenza and Other Respiratory Viruses: Prevention, Diagnosis, Treatment: 2nd Edition

edited by

Eric Yager

submission deadline 31 Aug 2025 | 7 articles | Viewed by 5604 | Submission Open

Keywords: influenza; adenovirus; coronoavirus; respiratory syncytial virus; rhinovirus; respiratory virus; antiviral strategies; epidemiology; diagnosis; treatment; vaccination; surveillance; vaccine development

(This special issue belongs to the Section Animal Viruses)

Natural, Semisynthetic, and Synthetic Antiviral Drugs Targeting HIV and SARS-CoV-2

edited by

Otávio Augusto Chaves

and

Carlos Serpa

submission deadline 31 Aug 2025 | 5 articles | Viewed by 5108 | Submission Open

Keywords: antiviral design and discovery; natural product screening; natural products as a scaffold for semisynthetic antivirals; repurposing drugs; high-throughput screening; antiviral resistance; biophysical characterization of the interaction between antivirals and targets; combination of light and photosensitizers in antiviral discovery; cell-based and in vivo assays; in silico calculations

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viral Mechanisms of Immune Evasion

edited by

Xiaoyong Bao

submission deadline 31 Aug 2025 | 4 articles | Viewed by 4793 | Submission Open

Keywords: immune evasion; virulent factor; antiviral signaling; pathogenesis; antiviral strategy

(This special issue belongs to the Section General Virology)

Viral Infections in Gynecological Diseases

edited by

Luca Roncati

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4588 | Submission Open

Keywords: herpes viruses; rubella virus; hepatitis viruses; parvovirus B19; HIV; HPV; Zika virus; placenta; gynecology; cancer

(This special issue belongs to the Section Human Virology and Viral Diseases)

Arboviruses and Global Health: A PanDengue Net Initiative

edited by

Carlos A. Sariol

and Jorge Osorio

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4318 | Submission Open

Keywords: dengue; zika; chikungunya; mayaro; aedes; immunology; pathogenesis; vector control

(This special issue belongs to the Section General Virology)

Beyond Acute: Navigating Long COVID and Post-Viral Complications

edited by Maggie Bartlett, Janko Nikolich-Žugich, Rubeshan Perumal and Anders Vahlne

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4290 | Submission Open

Keywords: long COVID; post-viral complications; dysregulated immune responses; neurological complications; respiratory complications; cardiovascular complications; pregnancy-related complications

(This special issue belongs to the Section Human Virology and Viral Diseases)

Antiviral Agents to Influenza Virus 2025

edited by Wu Zhong and

Manli Wang

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3942 | Submission Open

Keywords: influenza; antiviral drug; drug resistance; antiviral drug target

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Rodent-Borne Viruses 2025

edited by

Renata Carvalho De Oliveira

and

Jorlan Fernandes

submission deadline 31 Aug 2025 | 1 articles | Viewed by 3145 | Submission Open

Keywords: rodent-borne viruses; hantaviridae; arenaviridae; poxviridae; zoonosis; virus ecology and evolution; virus– host interaction; virus discovery; animal model; rodents

(This special issue belongs to the Section Animal Viruses)

Pathogenesis of Flavivirus Infections

edited by

Juarez Quaresma

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2776 | Submission Open

Keywords: pathogenesis; immunopathogenesis; immune response; clinical outcomes; vaccines; diagnostic; public health; one health; molecular biology; flavivirus; computer simulation; artificial intelligence

(This special issue belongs to the Section General Virology)

Bovine Viral Diarrhea Viruses and Other Pestiviruses

edited by

Enrica Sozzi

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2516 | Submission Open

Keywords: epidemiological survey; prevalence; seroprevalence; bovine viral diarrhoea; mucosal disease; neutralizing antibodies; taxonomy; antiviral drugs; vaccines; species and subgenotypes; wild animal

(This special issue belongs to the Section Animal Viruses)

Applications of Baculoviruses: Expression Factories, Vaccines and VLPs, Gene Delivery Vectors, and Virus Genetics Models

edited by

Linda King

and

Miguel López-Ferber

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2308 | Submission Open

Keywords: baculovirus; baculovirus– host cell interactions; baculovirus genetic diversity; baculovirus expression; baculovirus technology applications

(This special issue belongs to the Section Invertebrate Viruses)

Emerging and Re-Emerging Zoonotic Viruses: Current Challenges in Vaccinology

edited by Gema Lorenzo and Sandra Moreno

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2090 | Submission Open

Keywords: emerging zoonotic viruses; re-emerging zoonotic viruses; vaccine development; viral vector; reverse genetics systems

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Early Diagnosis and Surveillance of Transboundary and Emerging Viral Diseases of Animals, 2nd Edition

edited by

Aruna Ambagala

and

Kalhari Goonewardene

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1368 | Submission Open

Keywords: diagnostics; surveillance; transboundary; emerging; animal diseases; virus; detection; validation; novel; sample types; alternative

(This special issue belongs to the Section Animal Viruses)

Citrus Viral Diseases: Advances in Knowledge and Technologies and Their Containment Measures

edited by

Antonino F. Catara

Salvatore Davino

and Moshe Bar-Joseph

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1307 | Submission Open

Keywords: citrus viruses; genomic characterization; diagnostics; vector; virus– insect interactions; viral and virus-like pathogens

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Cyanophage and Algal Virus

edited by

Rodrigo Araújo Lima Rodrigues

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1046 | Submission Open

Keywords: cyanophages; algal viruses; Algavirales; Phycodnaviridae; Marnaviridae; aquatic virus; algae bloom; viral diversity; viral ecology

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

HIV and Viral Hepatitis Co-Infection

edited by

Sonia Moretti

and

Ivan Schietroma

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1018 | Submission Open

Keywords: HIV; hepatitis A; hepatitis B; hepatitis C; hepatitis delta; hepatitis E; co-infection; antiviral therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Herpesvirus Transcriptional Control

edited by

David Davido

submission deadline 31 Aug 2025 | 2 articles | Viewed by 913 | Submission Open

Keywords: herpes simplex virus; herpesvirus gene expression; viral latency and reactivation; virus– host interactions

(This special issue belongs to the Section Animal Viruses)

Advances in Honey Bee Viruses Research

edited by

Benjamin J. Lamp

and Kerstin Seitz

submission deadline 31 Aug 2025 | Viewed by 487 | Submission Open

Keywords: honey bee viruses; deformed wing virus; DWV; sacbrood virus; SBV; chronic bee paralysis virus; CBPV; acute bee paralysis virus; ABPV; Israel acute bee paralysis virus; IAPV; Iflavirus; Dicistrovirus; rhabdovirus; ARV

(This special issue belongs to the Section Invertebrate Viruses)

Navigating Viral Threats: Enteric and Respiratory Viral Challenges in the Post-COVID-19 Era

edited by Ahmed Mostafa and Abdou Allayeh

submission deadline 31 Aug 2025 | Viewed by 380 | Submission Open

Keywords: enteric viruses; respiratory viruses; human influenza viruses; COVID-19; avian influenza viruses; surveillance; virus epidemiology; viral diagnosis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Lytic Cycle of Herpesviruses and the Associated Pathogenesis

edited by Junjie Zhang,

Yonggang Pei

and Tingting Li

submission deadline 31 Aug 2025 | Viewed by 351 | Submission Open

Keywords: herpesviruses; innate immune responses; life cycle; herpesvirus– host interactions; pathogenesis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virus Polyproteins and Polyprotein Processing

edited by Martin Denis Ryan

submission deadline 31 Aug 2025 | Viewed by 287 | Submission Open

Keywords: virus polyproteins; polyprotein processing; translation

(This special issue belongs to the Section General Virology)

Innovative Prophylactic and Therapeutics for the Treatment of Coronavirus Infection

edited by

Luis Martinez-Sobrido

and Jun-Gyu Park

submission deadline 31 Aug 2025 | Viewed by 210 | Submission Open

Keywords: prophylactic; therapeutics; SARS-CoV-2; viral variants; antivirals

(This special issue belongs to the Section Coronaviruses)

Host-Mediated Viral Mutations: APOBECs, ADARs, and Beyond

edited by

Jaquelin P. Dudley

submission deadline 1 Sep 2025 | 3 articles | Viewed by 3800 | Submission Open

Keywords: cytosine and adenosine deamination; methylcytosine; epigenetics; mutagenesis; cancer; APOBEC antagonists; ADAR; DNA damage response; innate immunity; adaptive immunity; virus selection

(This special issue belongs to the Section Human Virology and Viral Diseases)

Human and Animal Papillomavirus: Infections, Genetics, and Vaccines

edited by

Antonio Carlos de Freitas

Marcus Vinícius de Aragão Batista

and

Maria Angélica Ramos da Silva

submission deadline 10 Sep 2025 | 8 articles | Viewed by 13861 | Submission Open

Keywords: vaccines; infection biology; genetics; molecular epidemiology; bioinformatics; oncogenesis; HPV and nongenital cancer; HPV and cancer; animal papillomavirus and associated diseases

(This special issue belongs to the Section Human Virology and Viral Diseases)

HIV and HTLV Infections and Coinfections

edited by

Carlos Brites

and

Antonio Vallinoto

submission deadline 30 Sep 2025 | 11 articles | Viewed by 19732 | Submission Open

Keywords: human T-cell leukemia virus; HIV; HTLV-associated diseases; HIV co-infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Recent Advances in Antiviral Natural Products 2025

edited by

Massimiliano Galdiero

Carla Zannella

Annalisa Chianese

and

Rosa Giugliano

submission deadline 30 Sep 2025 | 6 articles | Viewed by 17759 | Submission Open

Keywords: virus; antiviral; host-defense; natural product; drug delivery; infectious disease

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Host Cell-Virus Interaction, 4th Edition

edited by

Parikshit Bagchi

and

Anupam Mukherjee

submission deadline 30 Sep 2025 | 6 articles | Viewed by 11137 | Submission Open

Keywords: virus; viral proteins; virus entry; viral replication and pathogenesis; virus assembly and egress; intracellular trafficking of virus; host cell; cellular signaling; interferon pathway; inflammasome; viral immune evasion; immune response; cell death; apoptosis; autophagy; host-virus interaction; anti-viral strategies; direct acting antivirals; broad-spectrum antiviral agents; RNAi; microRNAs; neutralizing antibodies; molecular mechanisms of antivirals; molecular mechanisms of drug-resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Insect Viruses and Pest Management, the Third Edition

edited by

Miguel López-Ferber

submission deadline 30 Sep 2025 | 8 articles | Viewed by 10593 | Submission Open

Keywords: insect-specific viruses; pest control; virus-based biocontrol agents; quality control; industrial production; resistance development to virus-based biocontrol agents

(This special issue belongs to the Section Invertebrate Viruses)

Viruses and Eye Diseases

edited by Homayon Ghiasi and

Deepak Shukla

submission deadline 30 Sep 2025 | 5 articles | Viewed by 5755 | Submission Open

Keywords: ocular health; herpesviruses; herpes simplex virus (HSV); varicella zoster virus (VZV); adenovirus; respiratory viruses; Zika virus; cytomegalovirus (CMV); virus– ocular tissue interactions

(This special issue belongs to the Section Human Virology and Viral Diseases)

JC Polyomavirus

edited by

Sébastien Lhomme

and Anne-Sophie L'Honneur

submission deadline 30 Sep 2025 | 3 articles | Viewed by 5638 | Submission Open

Keywords: JC polyomavirus; progressive multifocal leukoencephalopathy (PML); neurotropic variants; viral genomic rearrangements

(This special issue belongs to the Section Human Virology and Viral Diseases)

Computational Biology of Viruses: From Molecules to Epidemics, Volume 2

edited by

Viktor Müller

submission deadline 30 Sep 2025 | 4 articles | Viewed by 5510 | Submission Open

Keywords: mathematical modeling; simulation modeling; molecular processes; within-host dynamics; epidemiological models; multiscale models

(This special issue belongs to the Section General Virology)

Coronaviruses Pathogenesis, Immunity, and Antivirals (2nd Edition)

edited by

Wentao Li

and Fei Yu

submission deadline 30 Sep 2025 | 6 articles | Viewed by 4575 | Submission Open

Keywords: coronavirus; pathogenesis; molecular; vaccines; evolution; immunity; antivirals

(This special issue belongs to the Section Coronaviruses)

Mechanisms of Herpesvirus Resistance

edited by

Graciela Andrei

submission deadline 30 Sep 2025 | 3 articles | Viewed by 3485 | Submission Open

Keywords: human herpesviruses; cytomegalovirus; drug resistance; antiviral agents; immunocompromised host; novel anti-herpesvirus therapies; DNA polymerase; terminase

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Mechanism of Receptor Recognition in Coronavirus, 2nd Edition

edited by

Qibin Geng

submission deadline 30 Sep 2025 | 2 articles | Viewed by 3424 | Submission Open

Keywords: receptor recognition; spike protein adaptations; receptor-binding domain (RBD); host range and zoonotic transmission; viral evolution and immune evasion; glycosylation and co-receptors; proteolytic activation; therapeutic and vaccine strategies; cross-species viral transmission; pandemic preparedness and surveillance

(This special issue belongs to the Section Animal Viruses)

Viral Diseases of Livestock and Diagnostics, 2nd Edition

edited by

Scott P. Kenney

submission deadline 30 Sep 2025 | 3 articles | Viewed by 3023 | Submission Open

Keywords: viral disease; zoonosis; zooanthroponosis; production animal

(This special issue belongs to the Section Animal Viruses)

Diversity and Evolution of Viruses in Ecosystem 2025

edited by

René Kallies

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2954 | Submission Open

Keywords: environmental virology; viral metagenomics; viral metatranscriptomics; phage genomics; virus evolution and phylogeny

(This special issue belongs to the Section General Virology)

Dual Nature of Bacteriophages: Friends or Enemies in Food Industry?

edited by

Barbara Sokolowska

Ewa Jończyk-Matysiak

and

Michał Wójcicki

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2873 | Submission Open

Keywords: bacteriophages; biocontrol; biosensors; food safety; foodborne bacterial pathogens; food quality; foodborne sapro-phytic bacteria

(This special issue belongs to the Section Bacterial Viruses)

Animal Herpesvirus 2025

edited by

Shafiqul Chowdhury

submission deadline 30 Sep 2025 | 4 articles | Viewed by 2500 | Submission Open

Keywords: herpesviruses; innate immune responses; host adaptive immune responses; herpesvirus-host; interactions; susceptibility

(This special issue belongs to the Section Animal Viruses)

Viral Diseases of Sheep and Goats

edited by Ramsés Reina and Álex Gómez

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2421 | Submission Open

Keywords: small ruminants; viral immunopathogenesis; infection; transmission; epidemiology; control strategies; vaccines

(This special issue belongs to the Section Animal Viruses)

Application of Plant Viruses in Biotechnology

edited by

Kathleen Hefferon

and

Srividhya Venkataraman

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2038 | Submission Open

Keywords: plant viruses; viral nanoparticles; plant viral vectors; biotechnological applications

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Broadly Protective Anti-Viral Vaccines 2025

edited by

Lei Deng

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1760 | Submission Open

Keywords: universal vaccines; structure-based rational design; cross-protection; broadly neutralizing antibody; T-cell epitopes; preventative and therapeutic vaccines; adaptive immunology; highly variable virus

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Development of Diagnostics and Therapeutic Interventions for Viral Infections of the Central Nervous System

edited by Karin E. Peterson and Amanda E. Calvert

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1250 | Submission Open

Keywords: encephalitis; arbovirus; diagnosis; treatment; neurovirology; antibody therapeutics; agnostic therapeutics; point of care diagnostics; rapid diagnostics

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Advances in Understanding Viral Pathogenesis and Host Immune Responses to Arboviruses and Respiratory Viruses

edited by

Laura Beatriz Talarico

and

Claudia Filomatori

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1246 | Submission Open

Keywords: arboviruses; respiratory viruses; viral pathogenesis; host immune responses; innate immunity; adaptive immunity; viral immune evasion; cytokine storm; interferon response; viral replication; viral transmission; immunopathology; neutralizing antibodies; host– virus interactions

(This special issue belongs to the Section Animal Viruses)

Molecular Epidemiology of SARS-CoV-2, 4th Edition

edited by

Marta Giovanetti

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1232 | Submission Open

Keywords: SARS-CoV-2; genomic monitoring; phylodynamic; molecular epidemiology

(This special issue belongs to the Section Coronaviruses)

Recent Advances in Anti-HCV, Anti-HBV and Anti-Flavivirus Agents, 2nd Edition

edited by

Grigoris Zoidis

submission deadline 30 Sep 2025 | 1 articles | Viewed by 748 | Submission Open

Keywords: medicinal chemistry of anti-HCV; anti-HBV and anti-flavivirus agents; synthesis; structure activity relationships (SAR); antiviral drug discovery; HBV; HCV; Dengue (DENV); Yellow Fever (YFV); West Nile (WNV); Zika (ZIKV); mechanism of action; drug targets; in silico studies

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Pathogenesis of Viral Infections

edited by

Cheng-Wen Lin

submission deadline 30 Sep 2025 | Viewed by 357 | Submission Open

Keywords: human and zoonotic viral diseases; viral pathogenesis; systems-level analyses; immune response; protein– protein interactions

(This special issue belongs to the Section General Virology)

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