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Viruses
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Pestivirus 2025
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Pestivirus 2025

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 30 October 2025 | Viewed by 312

Special Issue Editors

Prof. Dr. Benjamin J. Lamp

E-Mail Website
Guest Editor
Institute of Virology, Faculty of Veterinary Medicine, Justus-Liebig-University Giessen, Schubertstrasse 81, 35392 Giessen, Germany
Interests: viral-related diseases of livestock and insects; plus-strand RNA viruses; deformed wing virus; sacbrood virus; chronic bee paralysis virus; picornavirales; dicistroviruses; reverse genetics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Christiane M. Riedel

E-Mail Website
Guest Editor
CIRI-Centre International de Recherche en Infectiologie, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 Allee d'Italie, 69007 Lyon, France
Interests: pestiviruses; rhabdoviruses; cryo EM; structural virology; virus entry, cellular receptors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Traditional pestiviruses, such as the classical swine fever virus or the bovine viral diarrhea virus, are known agents of economically important animal diseases. However, recent research has led to the identification of many different related viruses that also infect previously unknown host species, such as cetaceans, rodents, or pangolins. It is likely that this is only the tip of the iceberg and that additional pestivirus species will be discovered soon.

Moreover, the impact of new species on the health status of individual animals or entire populations and the implications for the conservation of endangered species are still unknown. Although we had previously acquired knowledge on immunomodulatory proteins, the establishment of persistent infections, and the cellular host factors of pestiviruses, there have been recent breakthroughs in understanding the mechanisms underlying infection. Of particular note are recent studies on cellular receptor molecules, among which ADAM17 has been identified as a major host factor and direct interactor of the envelope protein E2.

The aim of this Special Issue is to present and summarize the latest discoveries in terms of basic research, developments, and advances in the epidemiology, diagnostics, and control of pestiviruses. An emphasis will be placed on pestiviral diseases, their pathogenesis, and their economic or environmental importance. Further investigation into newly discovered pestiviruses and the molecular infection mechanisms underlying known species will represent an exciting and important area of research going forward.

Prof. Dr. Benjamin J. Lamp
Prof. Dr. Christiane M. Riedel
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pestiviruses
  • classical swine fever virus
  • bovine viral diarrhea virus
  • BVDV-1
  • BVDV-2
  • CSF

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Published Papers (1 paper)

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Research

9 pages, 1103 KiB  
Article
Protective Efficacy of a Chimeric Pestivirus KD26_E2LOM Vaccine Against Classical Swine Fever Virus Infection of Pigs
by Young-Hyeon Lee, Bo-Kyoung Jung, Song-Yi Kim, Dohyun Kim, Min-Kyung Jang, SeEun Choe, Byung-Hyun An, Jae-Jo Kim, Yun Sang Cho and Dong-Jun An
Viruses 2025, 17(4), 529; https://doi.org/10.3390/v17040529 - 5 Apr 2025
Viewed by 219
Abstract
A chimeric pestivirus KD26_E2LOM strain can induce antibodies that can be partially distinguished from antibodies from classical swine fever virus (CSFV) infection. The chimeric pestivirus vaccine strain was created using bovine viral diarrhea virus as the backbone; however, the entire BVDV E2 gene [...] Read more.
A chimeric pestivirus KD26_E2LOM strain can induce antibodies that can be partially distinguished from antibodies from classical swine fever virus (CSFV) infection. The chimeric pestivirus vaccine strain was created using bovine viral diarrhea virus as the backbone; however, the entire BVDV E2 gene region was replaced with the E2 gene, which encodes the major target for neutralizing antibodies against CSFV. Pigs were vaccinated once or twice with the chimeric pestivirus KD26_E2LOM strain, and protective efficacy was evaluated after subsequent challenge with virulent CSFV. Pigs inoculated with the chimeric pestivirus KD26_E2LOM strain did not have a high temperature or leukopenia, and CSFV neutralizing antibodies (>64-fold) were observed from 28 days postvaccination (dpv). In addition, the level of anti-CSFV E2 antibody positivity was >0.8 (s/p value) from 30 dpv, and there were no antibody-positive individuals among the sentinel pigs. In control pigs, CSF antigen was detected in blood, nasal, and fecal samples at 5, 7, 10, 14, and 21 days postchallenge (dpc) and in several organs; however, no CSFV was detected in the organs of pigs vaccinated with the chimeric pestivirus KD26_E2LOM strain, and no virus shedding or CSF antigen was detected on any dpc. Thus, the chimeric pestivirus KD26_E2LOM strain protects pigs against horizontal transmission of virulent CSFV; however, this strain may have only partial potential for the differential detection of CSFV Erns antibodies. Full article
(This article belongs to the Special Issue Pestivirus 2025)
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