Advances in Small-Molecule Viral Inhibitors
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: 15 July 2025 | Viewed by 153
Special Issue Editor
Interests: small-molecule inhibitors; protein–protein interaction inhibitors; antiviral discovery; emerging viruses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Viral diseases still represent a terrible threat to public health due to the continuous emergence and re-emergence of different viruses that might cause epidemics or pandemics, as we recently experienced with SARS-COV-2. Despite many research efforts, many viral diseases still suffer from a lack of therapeutic measures.
Small-molecule inhibitors represent a potent tool in this scenario, as they can be designed to target and inhibit specific viral proteins, receptors, or enzymes involved in infectious processes. Such compounds usually have a molecular weight lower than 1000-1500 Da, allowing them to easily penetrate the cell membrane and thus target also intracellular components. The development of small-molecule antivirals is an important field of research that is continuously growing, thanks to the advances in medicinal chemistry and targeted screening strategies and the increasing availability of compounds’ virtual libraries.
For this Special Issue of Viruses, authors are encouraged to submit their latest findings and results on the characterization of small-molecule antivirals as original research papers. Presented data may include in vitro and in vivo or translational studies. Reviews summarizing the existing body of literature in this field are also welcome.
Dr. Chiara Bertagnin
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- small-molecule inhibitors
- PROTACs
- antiviral compounds
- drug discovery
- protein–protein interaction inhibitors
- enzymatic inhibitors
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