Bunyaviruses 2025

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 948

Special Issue Editors


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Guest Editor
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Interests: orthobunyaviruses; bandaviruses; oropouche virus; reassortment; viral–host interactions

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Guest Editor
Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA
Interests: arbovirus replication; transmission; reassortment; glycoprotein biology

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Guest Editor
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine and Indiana University Health, Indianapolis, IN 46202, USA
Interests: emerging and high-consequence viruses; development of diagnostics for emerging viral diseases; heartland virus; STFS virus; clinical microbiology

Special Issue Information

Dear Colleagues,

Bunyaviruses represent a diverse family of negative-sense RNA viruses with significant global health and veterinary impacts. This Special Issue explores the latest advancements in bunyavirus research, with a special emphasis on viruses belonging to the Peribunyaviridae, Phenuiviridae, and Nairoviridae families. We encourage submissions on viral evolution, reassortment, host–pathogen interactions, and emerging therapeutic strategies. Climate change and expanding urbanization are driving shifts in vector populations and habitats, increasing the geographic range and transmission potential of many arboviruses, including bunyaviruses. Understanding how environmental changes influence the emergence and spread of these viruses is critical for predicting and mitigating future outbreaks. We aim to highlight cutting-edge studies that address critical knowledge gaps and efforts to combat these pathogens. We therefore openly invite submissions on these or other topics of interest to the bunyavirus research community.

We look forward to receiving your contributions.

Dr. Natasha L. Tilston-Lunel
Dr. Kenneth A. Stapleford
Dr. Ryan F. Relich
Guest Editors

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Keywords

  • bunyaviruses
  • viral evolution
  • reassortment
  • vector biology
  • pathogenesis
  • animal models
  • vaccines and therapeutics

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Published Papers (1 paper)

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Research

16 pages, 2482 KiB  
Article
Genomic Insights into Neglected Orthobunyaviruses: Molecular Characterization and Phylogenetic Analysis
by Safiétou Sankhe, Idrissa Dieng, Mouhamed Kane, Amadou Diallo, Ndeye Awa Ndiaye, Ndeye Marieme Top, Moussa Dia, Ousmane Faye, Amadou Alpha Sall, Oumar Faye, Pape Mbacke Sembene, Cheikh Loucoubar, Martin Faye and Moussa Moise Diagne
Viruses 2025, 17(3), 406; https://doi.org/10.3390/v17030406 - 13 Mar 2025
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Abstract
Orthobunyaviruses are a diverse group of segmented RNA viruses with significant but underexplored public and veterinary health implications. This study provides a genomic, phylogenetic, and ecological analysis of neglected Orthobunyaviruses using next-generation sequencing and computational predictions. We identified unique phylogenetic relationships, with Tanga [...] Read more.
Orthobunyaviruses are a diverse group of segmented RNA viruses with significant but underexplored public and veterinary health implications. This study provides a genomic, phylogenetic, and ecological analysis of neglected Orthobunyaviruses using next-generation sequencing and computational predictions. We identified unique phylogenetic relationships, with Tanga virus forming a distinct lineage linked to zoonotic, human-associated, or non-vertebrate viruses across segments. GC content analysis revealed segment-specific patterns: higher GC content in the S segment suggests genomic stability and immune evasion, while lower GC content in the L segment reflects host-vector adaptation. Phylogenetic ties to well-characterized pathogenic viruses, such as Ilesha virus with Cache Valley virus and Bwamba virus with California encephalitis virus, indicate potential neurotropism. Ingwavuma virus clustered with Oropouche virus, suggesting risks of systemic febrile illnesses. Within the Simbu serogroup, Sango and Sabo viruses show teratogenic risks to livestock. Vector and host predictions implicate rodents, artiodactyls, and primates in Orthobunyavirus transmission, emphasizing complex ecological dynamics and zoonotic potential. These findings advance the understanding of Orthobunyavirus diversity, linking genomic features to pathogenicity and ecological adaptation, while providing a foundation for future surveillance and intervention strategies targeting these neglected viruses. Full article
(This article belongs to the Special Issue Bunyaviruses 2025)
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