Research and Clinical Application of Adenovirus (AdV), 3rd Edition
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: 25 May 2025 | Viewed by 1380
Special Issue Editor
Interests: adenovirus; oncolytic; cancer; models; gene; therapy; delivery; translation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The concept behind using viruses to fight human diseases is very straightforward: for millions of years, they have been delivering their genes to different types of mammalian and human cells. Indeed, virus-based gene therapy is a growing area of modern medicine, as viruses have the potential to overcome the limitations of conventional therapeutic approaches.
Adenovirus (AdV) is one of the most versatile viral backbones with applications ranging from gene delivery and treatment of monogenic diseases to vaccination and cancer therapy. Adenoviruses can target a broad spectrum of both dividing and non-dividing cells, do not integrate into host DNA, have high in vivo transduction capacity, and are well characterized, thereby allowing for countless modifications of their genetic structure. The first AdV-based therapy took place in 1956, when 30 patients with cervical carcinoma were treated with adenoidal–pharyngeal–conjunctival virus, now known as an adenovirus. After a turbulent past full of medical achievements and failures, the stigma related to adenovirus has been gradually replaced by the wide acceptance of the feasibility and safety of AdV-based therapeutics. It is difficult to overestimate the value of AdV during the COVID-19 pandemic as, to date, AdV represents the most effective viral vector platform for anti-SARS-CoV-2 vaccines. The recent clinical successes have also demonstrated the promise of tumor-selective, infectivity-improved oncolytic adenoviruses for cancer gene therapy and highlighted their role in inducing anticancer immunity.
This third Special Issue discusses the latest advances in adenovirus research and how AdV can treat human disease. The scope of this Special Issue includes but is not limited to:
- The molecular and cellular mechanisms of adenovirus infection and pathogenesis, including the molecular determinants of cell and tissue tropism, life cycle, transmission in the host, and mechanisms of cell death and tissue damage;
- Structure-based investigations of virus and virus capsid protein associations with cell receptors and innate immune molecules, as well as modulation and evasion of the host’s immune defense;
- Applications range from basic molecular tools to gene therapy, oncolytic virus therapy, immunotherapy, and vaccine development.
Dr. Julia Davydova
Guest Editor
Manuscript Submission Information
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Keywords
- adenovirus
- gene therapy
- cancer
- oncolytic
- vaccine
- delivery
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Related Special Issues
- Research and Clinical Application of Adenovirus (AdV) in Viruses (10 articles)
- Research and Clinical Application of Adenovirus (AdV), 2nd Edition in Viruses (11 articles)
